ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Apoptosis"

  • 2019 American Transplant Congress

    Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
  • 2019 American Transplant Congress

    NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice

    D. Choi1, J. Hwang2, J. Jeong3, K. Lee1, K. Na1, Y. Ham1, J. Jeon1, H. Kim1, Y. Chang1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, 3Medical Science, Chungnam National University, Daejeon, Korea, Republic of

    *Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
  • 2019 American Transplant Congress

    Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation

    A. Hosszu1, Z. Antal2, L. Illesy2, L. Lenart1, D. B. Balogh1, L. Wagner3, A. Vannay4, A. J. Szabo2, A. Fekete1

    1"Lendulet" Diabetes Research Group, MTA-SE, Budapest, Hungary, 21st Department of Pediatrics, Semmelweis University, Budapest, Hungary, 3Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, 4Pediatrics and Nephrology Research Group, MTA-SE, Budapest, Hungary

    *Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…
  • 2019 American Transplant Congress

    Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury

    S. Lan1, B. Yang1, M. Dieudé1, J. Sabo-Vatasescu2, A. Karakeussian-Rimbaud2, J. Turgeon2, S. Qi3, N. Patey4, M. Hébert1

    1Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, 2CRCHUM, Montreal, QC, Canada, 3Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, 4Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
  • 2019 American Transplant Congress

    Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK

    D. Choi1, J. Jeong2, K. Lee1, K. Na1, Y. Chang3, Y. Ham1, J. Jeon1, H. Kim1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Medical Science, Chungnam National University, Daejeon, Korea, Republic of, 3Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of

    *Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
  • 2019 American Transplant Congress

    CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury

    C. Akateh1, B. F. Reader1, Y. Lee1, J. Kim1, K. Maynard1, K. W. Washburn1, J. L. Zweier2, B. A. Whitson1, S. M. Black1

    1Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH

    *Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
  • 2019 American Transplant Congress

    Normothermic Ex Situ Liver Perfusion with Different Clinical Perfusates and Their Effect on Pig Liver Transplant Outcomes in a Donation after Circulatory Death Model

    I. Linares-Cervantes, D. Kollmann, T. Goto, J. Echeverri, M. Kaths, M. Hamar, P. Urbanellis, L. Mazilescu, R. Rosales, C. Bruguera, F. Oquendo, S. Ganesh, O. Adeyi, P. Yip, N. Selzner, M. Selzner

    Toronto General Hospital, Toronto, ON, Canada

    *Purpose: Human-albumin/Dextran (HA-D), Bovine-gelatin (BG) and packed red blood cells plus plasma have been used in European and North-American clinical trials of normothermic ex-situ liver…
  • 2018 American Transplant Congress

    Assessing the Impact of Flow in Hypothermic Machine Perfusion on Human Venous Endothelium Using a Novel Ex Vivo Model

    Y. Marie,1 W. Ries,2 K. Patel,1 C. Turnbull,2 N. Jamil,4 H. Caldwell,3 R. Telfer,2 D. Neil,5 J. Nath,1 N. Inston.1

    1Department of Renal Surgery, Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom; 2College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands, United Kingdom; 3Division of Pathology Laboratories, Western General Hospital, Edinburgh, United Kingdom; 4Department of Cellular Pathology, Durham and Darlington NHS Foundation Trust, Newcastle, Newcastle Upon Tyne, United Kingdom; 5Department of Histopathology, University Hospitals Birmingham NHS Trust, Birmingham, West Midlands, United Kingdom.

    BACKGROUNDHypothermic machine perfusion (HMP) involves dynamic flow of chilled preservation fluid through an allograft's vasculature. This study describes a simple, reproducible, human model that allows…
  • 2018 American Transplant Congress

    In Vivo Administration of Plerixafor and Bortezomib Results in Bone Marrow Plasma Cell Mobilization and Death While Inducing Biphasic Plasma Cell Apoptosis in Peripheral Blood

    E. Woodle,1 S. Tremblay,1 C. Castro-Rojas,2 S. Knechtle,3 A. Shields,1 R. Alloway,1 H. Singh,2 J. Driscoll,1 D. Hildeman.2

    1U Cincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham.

    Bone marrow (BM) plasma cells (PC) secreting HLA antibody (Ab) remain a persistent reservoir of donor specific Ab and present a significant hurdle to allograft…
  • 2018 American Transplant Congress

    NFkB Inhibitor Improves Glycemic Control after Syngeneic Islet Transplantation by Suppression of Proinflammatory and Apoptotic Gene Expression in a Cerulein-Induced Pancreatitis Model

    G. Yoshimatsu,1 C. Darden,2 K. Kumano,2 C. Chang,2 P. Saravanan,2 M. Lawrence,2 B. Naziruddin.3

    1Fukuoka University, Fukuoka, Japan; 2Baylor Scott and White Research Institute, Dallas; 3Baylor Simmons Transplant Institute, Dallas.

    Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. Repeated or continuous pancreatitis attack leads islet damage beyond inflamed exocrine…
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