Articles tagged "Apoptosis"

2021 American Transplant Congress
The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma
U. S. Udoh¹, J. D. Sanabria¹, M. Banerjee¹, P. K. Rajan¹, M. Schade¹, J. A. Sanabria¹, A. Mallick¹, G. Smith¹, G. U. Udoh², K. Sodhi¹, S. Pierre², Z. Xie², J. Shapiro², J. Sanabria¹
¹Dept. of Surgery/ Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV, ²Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV
*Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…
2021 American Transplant Congress
HLA I Antibody-Activated Endothelium Polarized M2-Like Macrophages with Increased Efferocytic and Phagocytic Capacity
J. Nevarez-Mejia¹, X. Wei¹, N. M. Valenzuela¹, M. Rossetti¹, H. Pickering¹, G. A. Fishbein¹, A. Mulder², E. F. Reed¹
¹Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands
*Purpose: The role of intragraft macrophages (Mϕs) during antibody-mediated rejection (AMR) remains unclear. Anti-HLA Abs during AMR drives vascular inflammation as seen by monocyte recruitment…
2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
2020 American Transplant Congress
Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats
H. Lin¹, S. Dai², W. Liu³, X. Lin², B. Yu², S. Chen³, S. Liu², J. Tang²
¹Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, ²Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, ³Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
*Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
2020 American Transplant Congress
Protective Effect of Fucoidan Against Tacrolimus-Induced Nephrotoxicity in LLC-PK1 Cells
H. J. Jang
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
2020 American Transplant Congress
Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury
S. Lan¹, B. Yang¹, J. Sabo-Vatasescu², M. Bourgault², A. Karakeussian-Rimbaud³, J. Turgeon³, S. Qi¹, N. Patey⁴, M. Dieudé⁵, M. Hébert¹
¹Medicine Faculty, CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³CRCHUM, CDTRP, Montreal, QC, Canada, ⁴Medicine Faculty, CRCHUM, Saint Justine Hospital, University of Montreal, Montreal, QC, Canada, ⁵CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
2020 American Transplant Congress
Caspase-1 Knockout Mice Have Increased Survival after Cold Ischemia in a Murine Kidney Transplant Model
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: Prolonged cold ischemia (CI) is a known risk factor for acute kidney injury (AKI) after kidney transplantation. However, the mechanism by which CI leads…
2020 American Transplant Congress
Immunomodulation with FasL Presenting Biomaterials Achieves Long-Term Survival of Allogeneic Islets in the Absence of Chronic Immunosuppression in a Non-Human Primate Model
J. Lei¹, H. Deng¹, T. Chen¹, K. Lee¹, C. Peters¹, Z. Yang¹, K. Deng¹, G. Rickert¹, I. Rosales¹, N. Serifis¹, M. Coronel², M. Hunckler², E. Yolcu³, H. Shirwan³, A. García², J. Markmann¹
¹Surgery, Mass General, Boston, MA, ²School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, ³School of Mechanical Engineering, University of Louisville School of Medicine, Louisville, KY
*Purpose: The full potential of islet transplantation will only be realized by the development of tolerogenic strategies that obviate the need for maintenance immunosuppressants. We…
2020 American Transplant Congress
3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy
A. M. Chen¹, W. Zhang¹, J. Sterner², L. Kennedy³, A. Isidan¹, E. Gramelspacher¹, H. L. Francis³, G. Alpini³, L. J. Smith², P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…
2020 American Transplant Congress
Endothelial Cells Internalize Apoptotic Exosome-Like Vesicles Through Phosphatidylserine-Dependent Macropinocytosis
F. Migneault, M. Dieudé, A. Brodeur, N. Thibodeau, D. Beillevaire, M. Hébert
CRCHUM, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion and rejection favor endothelial apoptosis, which in turn contributes to maladaptive vascular repair leading to transplant vasculopathy. Apoptotic endothelial cells (EC) release exosome-like…