Articles tagged "Apoptosis"

2021 American Transplant Congress
The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma
U. S. Udoh¹, J. D. Sanabria¹, M. Banerjee¹, P. K. Rajan¹, M. Schade¹, J. A. Sanabria¹, A. Mallick¹, G. Smith¹, G. U. Udoh², K. Sodhi¹, S. Pierre², Z. Xie², J. Shapiro², J. Sanabria¹
¹Dept. of Surgery/ Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV, ²Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV
*Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…
2021 American Transplant Congress
HLA I Antibody-Activated Endothelium Polarized M2-Like Macrophages with Increased Efferocytic and Phagocytic Capacity
J. Nevarez-Mejia¹, X. Wei¹, N. M. Valenzuela¹, M. Rossetti¹, H. Pickering¹, G. A. Fishbein¹, A. Mulder², E. F. Reed¹
¹Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands
*Purpose: The role of intragraft macrophages (Mϕs) during antibody-mediated rejection (AMR) remains unclear. Anti-HLA Abs during AMR drives vascular inflammation as seen by monocyte recruitment…
2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
2020 American Transplant Congress
Endothelial Cells Internalize Apoptotic Exosome-Like Vesicles Through Phosphatidylserine-Dependent Macropinocytosis
F. Migneault, M. Dieudé, A. Brodeur, N. Thibodeau, D. Beillevaire, M. Hébert
CRCHUM, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion and rejection favor endothelial apoptosis, which in turn contributes to maladaptive vascular repair leading to transplant vasculopathy. Apoptotic endothelial cells (EC) release exosome-like…
2020 American Transplant Congress
Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways
S. Chung, S. Choi
Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of
*Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
2020 American Transplant Congress
Apoptotic Exosome-Like Vesicles are Associated with Alloimmune Vascular Injury in Kidney Transplant Recipients
M. Dieude¹, E. Boilard², I. Allaeys², A. Deneault-Marchand¹, J. Turgeon¹, E. Dore², S. Lariviere-Beaudoin¹, A. Karakeussian-Rimbaud¹, S. Collette³, L. Senecal³, M. Hebert¹, H. Cardinal¹
¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, ²Centre de Recherche du Centre Hospitalier de l'Université de Québec, Quebec, QC, Canada, ³Hopital Maisonneuve-Rosemont, Montreal, QC, Canada
*Purpose: There is no non-invasive biomarker of alloimmune vascular injury. We have previously characterized exosome-like vesicles enriched in active proteasome and LG3 (ApoExo) that are…
2020 American Transplant Congress
Lack of Dj-1 Amplifies Sepsis-Associated Acute Kidney Injury and Increases Parenchymal Apoptosis
J. Leeds¹, Y. Scindia², E. Ghias¹, S. Cechova¹, V. Loi¹, E. Mandziak¹, S. Swaminathan¹
¹University of Virginia, Charlottesville, VA, ²University of Florida, Gainesville, FL
*Purpose: Sepsis following kidney transplantation is a frequent complication due to mandatory immunosuppression and increased infection risk. Kidney transplant recipients who develop sepsis show inferior…
2020 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptors in Liver Ischemia/Reperfusion Injury
J. Zhang, M. Ni, D. Jin, H. Zhang, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
2020 American Transplant Congress
Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion
Y. Kim¹, K. Kim¹, J. Lee¹, J. Moon¹, J. Kim¹, J. Lee², Y. Kim¹, S. Yang¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of
*Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
2020 American Transplant Congress
CEACAM1 / ASK1 / p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human
H. Hirao¹, K. Nakamura², S. Kageyama¹, T. Ito¹, K. Kadono¹, H. Kojima¹, K. J. Dery¹, S. Younan¹, R. W. Busuttil¹, F. M. Kaldas¹, J. Kupiec-Weglinski¹
¹UCLA, Los Angeles, CA, ²Kyoto University, Kyoto, Japan
*Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains unknown. A…