Articles tagged "Antilymphocyte antibodies"

2015 American Transplant Congress
Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells
K. Samy, H. Xu, A. Kirk.
Surgery, Duke University Medical Center, Durham, NC.
Current induction therapy using thymoglobulin (ATG) results in nonspecific T cell depletion. We have generated a polyclonal rabbit anti-human leukocyte globulin (RALG) by immunizing rabbits…
2015 American Transplant Congress
Increased Late Graft Loss in Kidney Recipients With Serum Sickness Disease Following Anti-Thymocyte Globulin Induction: Relation With an Anti-Neu5Gc Response
A. Salama,^1,2 G. Couvrat-Desvergnes,¹ M. Lorent,^1,3 G. Evanno,¹ L. Le Berre,¹ P. Hruba,⁴ P. Vesely,⁵ P. Guerif,¹ A. Nicot,¹ J.-M. Bach,⁶ Y. Foucher,^1,3 S. Brouard,¹ S. Castagnet,⁷ O. Viklicky,⁴ M. Giral,¹ J. Harb,¹ S. Jean-Paul.¹
¹INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; ²Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; ³EA 4275 SPHERE, Biostatistics, Clinical Research and Pharmaco-Epidemiology, Nantes, France; ⁴Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁵Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; ⁶IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; ⁷EFS Pays de la Loire, Nantes, France.
Anti-thymocyte globulins (ATG) are rabbit IgGs against human T cells widely used as induction treatment of kidney recipients. ATG can induce immune-complex diseases including Serum…
2015 American Transplant Congress
Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs
A. Salama,^1,2 S. Conchon,¹ A. Perota,³ B. Martinet,¹ J.-P. Judor,¹ G. Evanno,¹ S. Le-Bas Bernardet,¹ L. Le Berre,¹ J. Hervouet,¹ D. Minault,¹ J.-P. Concordet,⁴ E. Dugast,¹ B. Vanhove,¹ J. Abadie,⁵ N. Gaide,⁵ I. Lagutina,³ R. Duchi,³ G. Lazzari,³ D. Sachs,⁶ O. Gauthier,⁷ S. Brouard,¹ E. Cozzi,⁸ G. Blancho,¹ H. Perreault,⁹ J.-M. Bach,¹⁰ C. Galli,^3,11 J.-P. Soulillou.¹
¹INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; ²Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; ³Avantea, Laboratory of Reproductive Technologies, Cremona, Italy; ⁴INSERM U565, CNRS UMR7196, MNHN USM503, Paris, France; ⁵AMaROC, ONIRIS, Nantes, France; ⁶Massachusetts General Hospital, Transplantation Biology Research Center, Boston, MA; ⁷Centre de Recherche et d'Investigation Préclinique, ONIRIS, Nantes, France; ⁸Padua General Hospital and Consortium for Research in Organ Transplantation, Padua, Italy; ⁹Chemistry Department, University of Manitoba, Winnipeg, Canada; ¹⁰IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; ¹¹Dept. of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Xenotransplantation offers a large number of potential applications, including solid organs, pancreatic islets, acellular tissues such as heart valves and skin grafts, and new bioreagents…
2015 American Transplant Congress
Antithymocyte Globulin-Induced Platelet Hypercoagulability Is a Consequence of Complement Activation and Microvesicle Release
D. Zecher,^1,4 A. Cumpelik,¹ D. Tsakiris,² M. Dickenmann,³ J. Schifferli.¹
¹Department of Research, Basel University Hospital, Basel, Switzerland; ²Department of Hematology, Basel University Hospital, Basel, Switzerland; ³Department of Nephrology, Basel University Hospital, Basel, Switzerland; ⁴Department of Nephrology, Regensburg University Hospital, Regensburg, Germany.
T cell depletion with antithymocyte globulins (ATG) can be complicated by thrombopenia andhypercoagulability. The underlying mechanism is still unclear. We found that binding of ATG…
2015 American Transplant Congress
Steroid Free Immunosuppression Protocol in Pediatric Kidney Transplant Recipients Using Alemtuzumab: A Retrospective Single Center Study
R. Shah,¹ Z. Kadry,¹ S. Wassner,² D. Kees-Folts,² M. Freeman,² P. Freeman,¹ B. Olenowski,¹ A. Jain.¹
¹Surgery, Hershey Medical Center, Hershey, PA; ²Pediatric Nephrology, Hershey Medical Center, Hershey, PA.
Background: Steroid free immunosuppression is attractive in pediatric kidney transplantation (KTx). Aim of the present study is to examine the patient survival, graft survival, rate…
2015 American Transplant Congress
Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus
H. Tedesco-Silva,¹ C. Felipe,¹ A. Ferreira,¹ M. Cristelli,¹ T. Sandes- Freitas,¹ N. Oliveira,¹ W. Aguiar,² G. Bassos,¹ M. Franco,³ M. Gerbase- Lima,⁴ E. Campos,⁴ J. Medina-Pestana.¹
¹Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ²Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ³Pathology, UNIFESP, Sao Paulo, Brazil; ⁴Immunogenetic, AFIP, Sao Paulo, Brazil.
BACKGROUND: CMV infection is associated with inferior long-term kidney transplant outcomes. This study compared the incidence of CMV infection/disease in de novo kidney transplant recipients…
2015 American Transplant Congress
Blocking CD4 T Cell Helper Functions Improves Efficacy of ATG Treatment in Sensitized Transplant Recipients
K. Ayasoufi, X. Wang, H. Yu, V. Gorbacheva, F. Ran, R. Fairchild, A. Valujskikh.
Immunology, Cleveland Clinic, Cleveland, OH.
Antibody mediated lymphocyte depletion is used in clinical transplantation to improve graft function. While the presence of donor-reactive memory T cells is the primary rationale…
2015 American Transplant Congress
Reciprocal Relationship Between Cytomegalovirus Infection and Graft Rejection in Intestinal/Multivisceral Transplantation: Impact on Survival and Ideal Immunosuppression Protocol
S. Nagai, R. Mangus, E. Anderson, K. Doan, B. Ekser, C. Kubal, J. Fridell, A. Tector.
Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN.
Background: Cytomegalovius (CMV) infection and graft rejection are opposing complications of isolated intestinal/multivisceral transplantation (IIT/MVT), a procedure requiring precise balance of immunosuppression. The aim of…