Articles tagged "Antilymphocyte antibodies"

2018 American Transplant Congress
Survey of Rabbit Anti-Thymocyte Globulin Usage for Kidney Transplant Induction Therapy in the United States
K. Foster,¹ A. Dodson,² K. Gutierrez.²
¹Samford University McWhorter School of Pharmacy, Birmingham, AL; ²Comprehensive Transplant Institute, UAB Hospital, Birmingham, AL.
Background: Rabbit anti-thymocyte globulin (rATG) has become the most widely used induction agent in kidney transplantation (KTx) and has recently received FDA approval for this…
2018 American Transplant Congress
Outcomes Associated with Rabbit Anti-Thymocyte Globulin Induction According to Mg/Kg of Total Body Weight in Kidney Transplant Recipients
A. Brueckner, A. Logan, L. Bowman.
Pharmacy, Tampa General Hospital, Tampa, FL.
Purpose: The optimal dosing weight used for rabbit anti-thymocyte globulin (rATG) induction therapy in transplantation continues to lack a consensus. The impact of alternative dosing…
2017 American Transplant Congress
B Cell-Derived Cytokines Rather Than T/B Cognate Interactions Mediate CD8 T Cell Reconstitution Following Lymphoablation.
D. Zwick, K. Ayasoufi, R. Fan, V. Gorbacheva, K. Keslar, R. Fairchild, A. Valujskikh.
Immunology, Cleveland Clinic, Cleveland, OH
Antibody-mediated lymphoablation is a commonly used induction therapy in sensitized transplant recipients. Using murine anti-thymocyte globulin (mATG) in a model of BALB/c (H-2d) to B6…
2017 American Transplant Congress
Usefulness of Valacyclovir Prophylaxis for Preventing Cytomegalovirus Infection After Anti-Thymocyte Globulin Treatment as Antirejection Therapy.
E. Ko,^1,2 J. Yu,^1,2 B. Choi,^1,2 C. Park,^1,2 Y. Kim,^1,2 C. Yang,^1,2 B. Chung.^1,2
¹Transplant Research Center, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea; ²Division of Nephrology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea
Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of CMV infection. We purposed to evaluate the effect of valacyclovir…
2017 American Transplant Congress
Using Basiliximab Does Not Increase De Novo DSA Incidence but Reduces Cytomegalovirus Infections and Neoplastic Complications in Non-Sensitized Kidney Transplant Patients.
M. Marron-Wojewodzki,¹ I. Szwarc,¹ C. Rene,² J.-F. Eliaou,² G. Mourad,¹ M. Le Quintrec.^1,3
¹Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier University Hospital, Montpellier, France; ²Departement of Immunology, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France; ³Inserm U1183, IRMB, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France
Background. In kidney transplantation, de novo donor specific antibodies (dnDSA) are associated with antibody-mediated rejection (AMR) and graft failure. After dnDSA development, 24% of the…
2017 American Transplant Congress
Biomarkers of Epithelial-Mesenchymal Transition (EMT) in Chronic Allograft Nephropathy: Potential for Early Detection and Development of Novel Therapeutic Agents.
S. Kanangat, R. Miller, S. Rezaeian, H. Eldib, D. Cimbaluk, C. Fhied, I. Kurbegovic-Skaljic, M. Prod, J. Borgia, M. Flaws, D. Castillo, R. DeCresce.
Pathology, BioChemistry and Medical Laboratory Sciences, Rush University Medical Center, Chicago, IL
Purpose: To detect markers and novel treatment targets related to fibrogenesis and eventual graft loss by focusing on Epithelial Mesenchymal transition (EMT) which requires understanding…
2016 American Transplant Congress
Surveillance Biopsy Findings with Alemtuzumab (ALZ) Induction in Kidney Transplantation.
H. Madariaga,¹ R. Ugarte,¹ C. Drachenberg,² N. Costa,¹ B. Thomas,¹ J. Bromberg,³ M. Weir,¹ A. Haririan.¹
¹Department of Medicine, University of Maryland Medical Center, Baltimore, MD; ²Department of Pathology, University of Maryland Medical Center, Baltimore, MD; ³Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
The risk of subclinical histological changes in renal allografts with ALZ induction is not well defined. Hence, we performed a retrospective analysis of 527 surveillance…
2016 American Transplant Congress
Continuous Antithymocyte Globulin (rATG) for Treatment of Renal Allograft Rejection: Preliminary Analysis of a Prospective, Randomized Trial.
S. Patel, R. Knight, S. Kuten, J. Nolte, A. Gaber.
Houston Methodist Hospital, Houston, TX.
Intravenous (IV) rATG for acute rejection (AR) is primarily given on an inpatient basis due to its daily administration, IV access requirement, and monitoring. The…
2016 American Transplant Congress
CD45RO+/CD62L- Effector Memory T Cells Mediate Depletion Resistant Allograft Rejection in Intestinal Transplant Recipients.
C. Cosentino, J. Kaiser, A. Shukla, C. Desai, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.
MedStar Georgetown Transplant Institute, Washington DC.
A. A high risk of acute cellular rejection (ACR) is one of the key factors limiting intestinal transplantation (ITx). An extremely poor prognosis is related…
2016 American Transplant Congress
Limiting Helper Functions of CD4 T Cells Improves Efficacy of Induction Therapy without Compromising Responses to Third Party Antigens.
K. Ayasoufi, V. Gorbacheva, F. Ran, A. Valujskikh.
Cleveland Clinic, Cleveland.
Antibody mediated lymphocyte depletion is commonly used in clinical transplantation. However, memory T cells undermine the efficacy of lymphoablative induction therapies in sensitized transplant recipients.…