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American Transplant Congress abstracts

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Articles tagged "Antilymphocyte antibodies"

  • 2020 American Transplant Congress

    Causal Relationship between Anti-Thymocyte Globulin Induction Therapy and Development of Monomorphic PTLD in Renal Transplant Recipients

    K. Soliman1, H. Ali2, T. Fulop1, A. Osman3, A. Halawa4

    1Medicine, Medical University of South Carolina, Charleston, SC, 2Medicine, Royal Stoke, Royal Stoke, United Kingdom, 3Medicine, Cairo University, Cairo, Egypt, 4Medicine, University of Liverpool, Liverpool, United Kingdom

    *Purpose: The aim of our study is to explore the causality between ATG and different types of post-transplant lymphoproliferative disorder (PTLD) in renal transplant recipients…
  • 2020 American Transplant Congress

    Comparison of Short-Term Outcomes of Induction Therapy with Alemtuzumab versus Rabbit Antithymocyte Globulin in Lung Transplantation

    V. Liu, M. W. Soto-Arenall, A. Patel

    Pharmacy, Mayo Clinic, Jacksonville, FL

    *Purpose: To identify the short-term efficacy and safety outcomes of alemtuzumab (C1H) versus rabbit antithymocyte globulin (rATG) in lung transplant patients. The objectives are to…
  • 2020 American Transplant Congress

    A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease

    S. M. Keating, A. S. Adler, R. A. Mizrahi, J. Leong, M. A. Asensio, Y. W. Lim, A. R. Niedecken, Y. Chiang, R. Leong, D. S. Johnson

    Immunology, GigaGen, South San Francisco, CA

    *Purpose: Anti-thymocyte globulin (ATGs) are polyclonal antibody products that target and deplete T cells for immunosuppression in transplantation (prophylaxis of rejection). Since ATGs are derived…
  • 2020 American Transplant Congress

    Depletional Profiles of Human and Rhesus Specific Anti-Thymocyte Globulins in Rhesus Macaques

    B. I. Shaw1, R. Schmitz1, D. M. Magnani2, F. Leopardi1, A. D. Kirk1

    1Surgery, Duke University, Durham, NC, 2Medicine, MassBiologics of the University of Massachusetts Medical School, Boston, MA

    *Purpose: Rabbit anti-human ATG (rATG; Thymoglobulin®) is the most commonly used formulation for depletional induction therapy in the United States. However, given that it is…
  • 2020 American Transplant Congress

    Outcomes of Acute Allograft Rejection Treatment with R Anti-Thymocyte Globulin (r-ATG) One Year Post Kidney Transplant

    M. Yaqub, A. Riaz, D. Mishler, O. Adebiyi, T. Taber, A. Sharfuddin

    Indiana University School of Medicine, Indianapolis, IN

    *Purpose: Acute allograft rejection is considered one of the major causes of renal allograft dysfunction. Despite maximal anti-rejection therapy grafts may not regain baseline function.…
  • 2020 American Transplant Congress

    Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture

    M. Colladant1, J. Lion2, P. Saas3, S. Perruche3, D. Ducloux1, N. Mooney2, J. Bamoulid1

    1Nephrologie, Dialyse et Transplantation, CHU de Besançon, Besancon, France, 2Equipe INSERM: Endothelium, Inflammation et Alloreactivity INSERM UMR-S 976, Paris, France, 3INSERM U1098 RIGHT, Université de Franche-Comté EFS Bourgogne Franche-Comté, Besancon, France

    *Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…
  • 2020 American Transplant Congress

    Carfilzomib-Based Desensitization: Effects on HLA, Non-HLA, Auto, and Antiviral Antibodies

    S. Tremblay1, E. Portwood1, A. R. Shields2, R. R. Alloway1, P. A. Brailey1, E. Woodle1

    1U Cincinnati, Cincinnati, OH, 2U Cincinnati, Christ Hospital, Cincinnati, OH

    *Purpose: An important question in plasma cell (PC) therapies is the specificity of therapy for PC populations. It is known that plasmablast populations are exquisitely…
  • 2020 American Transplant Congress

    Thymoglobulin Dose and Incidence of Biopsy Proven Acute Rejections in the Early Post Transplant Period

    K. Shimko, K. Schonder, D. Jorgensen, K. Kalra, A. Cherukuri, R. Mehta, I. Melgarejo, P. Sood, S. Hariharan, R. Mehta

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: Optimal dosing of thymoglobulin (ATG) for induction has not been well defined. Our protocol aims for 5-6mg/kg cumulative dose divided over 4 doses. However,…
  • 2020 American Transplant Congress

    Short Term Outcomes in Kidney Transplant Patients Receiving De Novo Belatacept with Anti-Thymocyte Globulin Induction

    B. Carlson, P. Cabrera, T. Harrison, K. Tejani, A. Centeno

    Pharmacy, Jackson Memorial Hospital, Miami, FL

    *Purpose: Mainstay immunosuppressive therapy after kidney transplant is a calcineurin inhibitor (CNI) based regimen. Nephrotoxicity is a common adverse effect of CNIs which can lead…
  • 2019 American Transplant Congress

    Allogenic Islets Cure Diabetes Following Transplantation in Omental Pouch in a Non-Human Primate Model

    J. Lei1, H. Deng1, K. Lee1, C. Peters1, G. Rickert1, R. Ivy1, M. Coronel2, E. Yolcu3, H. Shirwan4, A. García5, J. Markmann1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Surgery, Georgia Institute of Technology, Atlanta, GA, 3Institute for Cellular Therapeutics, University of Louisville School of Medicine, louisville, KY, 4Department of Microbiology and Immunology, University of Louisville School of Medicine, louisville, KY, 5School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA

    *Purpose: In the current standard clinical transplant approach, islet cells are administered intravenously into the portal system where they lodge in the liver. This approach…
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