2015 American Transplant Congress
Enhanced Requirement for TNF Signaling on Low Affinity Memory CD8+ T Cells During Heterologous Immunity
Heterologous immunity, defined as a process during which microbe-specific T cells cross-react with allogeneic antigen and mediate graft rejection, is recognized as a significant barrier…2015 American Transplant Congress
T Cell C5a Receptor (C5aR) Signaling Regulates T Follicular Helper Cell (Tfh) Induction
Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.
Tfh cells, in part via IL-6 dependent production of IL-21, are specialized providers of B cell help. Extending previous work in which we showed that…2015 American Transplant Congress
Diabetic Kidney Transplant Recipients: Impaired Infection Control and Alloreactivity
New onset diabetes after transplant (NODAT) has been associated with an increased risk of infection and sepsis. Previous studies, however, failed to identify differences in…2015 American Transplant Congress
Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation
Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…2015 American Transplant Congress
Innate Immune Memory to Allogeneic Non-Self
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
A hallmark of adaptive immunity is the generation of long-lived, antigen-specific memory T, B, and NK lymphocytes that mount strong anamnestic (recall) responses to previously…2015 American Transplant Congress
Histologic Patterns of C4d Associated With Acute Antibody Mediated Rejection of the Lung Allograft
Pathology, UT Southwestern Medical Center, Dallas, TX.
The diagnosis of antibody mediated rejection (AMR) of the lung allograft still represents a diagnostic challenge for pathologist and transplant physicians alike. The morphologic and…
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