ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Allorecognition"

  • 2015 American Transplant Congress

    Differential Role of PI3K Subunits Gamma and Delta in Regulatory T Cells Homeostasis in Allotransplantation

    J. Azzi, M. Uehara, Z. Solhjou, P. Lukyanchykov, A. Radwan, L. Riella, R. Abdi.

    Renal/Transplant Research Center, Brigham and Women's Hospital, Boston, MA.

    Targeting survival pathways that differentially suppress effector T cells (Teff) while sparing regulatory T cells (Tregs) is key in devising novel tolerogenic protocols in transplantation.…
  • 2015 American Transplant Congress

    Bidirectional Regulation and IL35 Surface Expression By Treg Cells

    Y. Tomita, W. Burlingham.

    Surgery, University of Wisconsin, Madison, WI.

    Background: Pre-transplant regulation on the donor side(toward the recipient), as well as the recipient side(toward the donor) promotes long-term graft survival of a kidney allo-graft…
  • 2015 American Transplant Congress

    Dramatic Primary Expansion of Indirect CD4 T Cells to Allogeneic APCs In Vivo

    N. Bishop,1 M. Nelsen,1 M. Coulombe,2 R. Gill.2

    1Immunology, University of Colorado Denver, Aurora, CO; 2Surgery, University of Colorado Denver, Aurora, CO.

    An ongoing question regarding the primary allograft response is the relative contribution of the 'direct' (donor MHC-restricted) versus 'indirect' (host MHC-restricted) pathways of T cell…
  • 2015 American Transplant Congress

    Diabetes Mellitus Predicts Outcome in Obesity After Kidney Transplantation

    T. Schachtner,1,2 P. Reinke.1,2

    1Nephrology and Internal Intensive Care, Charité Campus Virchow Clinic, Berlin, Germany; 2Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.

    Obesity has been associated with an increased risk of graft loss and death after kidney transplantation. The role of cellular immunity in obese kidney transplant…
  • 2015 American Transplant Congress

    Cytotoxic CD8 T Cell Recognition of Acquired, Intact MHC Alloantigen On Host Dendritic Cells Promotes Acute Allograft Rejection

    J. Ali, S. Harper, M. Negus, E. Bolton, J. Bradley, G. Pettigrew.

    University of Cambridge, Cambridge, United Kingdom.

    IntroductionAlthough there is increasing evidence that recipient DCs can acquire intact MHC class I by trogocytosis from parenchymal cells, the functional relevance of the 'semi-direct'…
  • 2015 American Transplant Congress

    Cellular Mechanism of Enhanced Alloimmunity by Ischemia Reperfusion Injury

    Z. Solhjou, M. Uehara, S. Ohori, M. McGrath, J. Azzi, S. Tullius, R. Abdi.

    Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

    Ischemia reperfusion injury of transplanted organs represents a key pathogenic inflammatory process, which increases their allogenicity; subsequently augmenting the rate of acute and chronic rejection.…
  • 2015 American Transplant Congress

    Rational Development of Alloantigen Specific Regulatory T Cell Therapy Requires Insight Into Longevity of Alloimmune Pathways

    J. Ali, M. Negus, E. Bolton, J. Bradley, G. Pettigrew.

    University of Cambridge, Cambridge, United Kingdom.

    IntroductionWe have recently demonstrated that indirect-pathway responses against different alloantigens differ in their strength and longevity; specifically, that indirect responses against MHC class I alloantigen…
  • 2015 American Transplant Congress

    IL-2-Dependent Natural Killer Cell Responses to Epstein-Barr Virus B Cell Lymphomas Involve the NKG2A/NKG2C Axis

    O. Hatton, D. Strauss-Albee, C. Blish, C. Esquivel, S. Krams, O. Martines.

    Stanford University School of Medicine, Stanford, CA.

    Epstein Barr virus (EBV) infection elicits a strong host immune response that is considered to be essential for control of the virus and for preventing…
  • 2015 American Transplant Congress

    Controlling Alloreactive B Cell Responses in Sensitized Recipients With CTLA-4Ig

    J. Chen,1 Q. Wang,1 D. Yin,1 V. Vu,1 R. Sciammas,2 A. Chong.1

    1Depart of Surgery, University of Chicago, Chicago; 2Immunobiology Transplant Center, Houston Methodist Research Institute, Houston.

    Sensitized recipients are defined by the presence of pre-transplant donor-specific antibodies and have significantly poorer graft outcomes compared to unsensitized recipients despite efforts to desensitize.…
  • 2015 American Transplant Congress

    Virus Induced CD28 Down-Regulation as a Potential Driver of Costimulation Blockade Resistant Rejection

    D. Mou,1 J. Espinosa,1 L. Stempora,2 J. Kwun,2 N. Iwakoshi,1 A. Kirk.2

    1Surgery, Emory University, Atlanta, GA; 2Surgery, Duke University, Durham, NC.

    Belatacept, a B7-specific fusion protein, blocks CD28-B7 costimulation and prevents kidney allograft rejection. However, it is ineffective in a sizable minority of patients. Although T…
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