ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Allorecognition"

  • 2015 American Transplant Congress

    Diabetic Kidney Transplant Recipients: Impaired Infection Control and Alloreactivity

    T. Schachtner,1,2 M. Stein,2 P. Reinke.1,2

    1Nephrology and Internal Intensive Care, Charité Campus Virchow Clinic, Berlin, Germany; 2Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.

    New onset diabetes after transplant (NODAT) has been associated with an increased risk of infection and sepsis. Previous studies, however, failed to identify differences in…
  • 2015 American Transplant Congress

    Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation

    E. Crespo,1 M. Lucia,1 J. Cruzado,1,2 S. Luque,1 E. Melilli,2 A. Manonelles,1,2 N. Sala,2 J. Grinyó,1,2 O. Bestard.1,2

    1Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; 2Nephrology Department and Renal Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.

    Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…
  • 2015 American Transplant Congress

    Innate Immune Memory to Allogeneic Non-Self

    H. Dai, A. Williams, M. Oberbarnscheidt, F. Lakkis.

    Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.

    A hallmark of adaptive immunity is the generation of long-lived, antigen-specific memory T, B, and NK lymphocytes that mount strong anamnestic (recall) responses to previously…
  • 2015 American Transplant Congress

    Histologic Patterns of C4d Associated With Acute Antibody Mediated Rejection of the Lung Allograft

    Y. Butt, J. Hassler, V. Kaza, F. Torres, J. Torrealba.

    Pathology, UT Southwestern Medical Center, Dallas, TX.

    The diagnosis of antibody mediated rejection (AMR) of the lung allograft still represents a diagnostic challenge for pathologist and transplant physicians alike. The morphologic and…
  • 2015 American Transplant Congress

    Host NK Cell Allorecognition of Passenger Donor Lymphocytes Within Allografts Is Essential for Preventing Augmentation of Recipient Adaptive Alloimmunity

    J. Ali, I. Harper, M. Negus, E. Bolton, K. Saeb-Parsy, J. Bradley, G. Pettigrew.

    Department of Surgery, University of Cambridge, Cambridge, United Kingdom.

    Background:Memory T cells are now appreciated to reside in peripheral non-lymphoid tissue, but how their presence within solid organ allografts impacts upon transplant outcomes is…
  • 2015 American Transplant Congress

    Microchimerism-Tolerance “Missing Link”: Exosome Acquisition by Host Dendritic Cells

    W. Bracamonte-Baran, E. Jankowska-Gan, Y. Zhou, W. Burlingham.

    Surgery, University of Wisconsin, Madison, WI.

    Background: widespread maternal microchimerism (MMc) in mice is associated with development of immune regulation, which can be used to predict transplantation tolerance. We recently showed…
  • 2015 American Transplant Congress

    Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation

    J. Marino,1 P. Crosby Bertorini,1 M. Uehara,2 J. Paster,1 S. Mordecai,3 W.-H. Liu,1 L. Liu,1 R. Abdi,2 G. Tocco,1 J. Kim,1 J. Markmann,1 G. Benichou.1

    1Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA; 2Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA; 3Department of Pathology, Flow and Imaging Cytometry Core, Massachusetts General Hospital, Boston, MA.

    We have studied the kinetics of donor cell trafficking from the graft to recipient's lymphoid organs and its correlation to the direct T cell alloresponse…
  • 2015 American Transplant Congress

    IgM+ Antigen Binding B Cells in Peripheral Blood Regulate IFNγ Production in Response to HLA Proteins

    L. McLaughlin,1 K. Shiu,1 G. Lombardi,1 J. Spencer,2 R. Vaughan,1 A. Dorling.1

    1MRC Centre for Transplantation, King's College London, London, United Kingdom; 2Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom.

    Chronic antibody mediated rejection (CAMR) is a major cause of graft loss in renal transplant recipients. Previous work utilising an IFNγ ELISPOT assay revealed two…
  • 2015 American Transplant Congress

    Differential Role of PI3K Subunits Gamma and Delta in Regulatory T Cells Homeostasis in Allotransplantation

    J. Azzi, M. Uehara, Z. Solhjou, P. Lukyanchykov, A. Radwan, L. Riella, R. Abdi.

    Renal/Transplant Research Center, Brigham and Women's Hospital, Boston, MA.

    Targeting survival pathways that differentially suppress effector T cells (Teff) while sparing regulatory T cells (Tregs) is key in devising novel tolerogenic protocols in transplantation.…
  • 2015 American Transplant Congress

    Bidirectional Regulation and IL35 Surface Expression By Treg Cells

    Y. Tomita, W. Burlingham.

    Surgery, University of Wisconsin, Madison, WI.

    Background: Pre-transplant regulation on the donor side(toward the recipient), as well as the recipient side(toward the donor) promotes long-term graft survival of a kidney allo-graft…
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