Articles tagged "Allorecognition"

2016 American Transplant Congress
Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.
L. Margoles, S. Laurie, C. Coopersmith, M. Ford.
Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA.
Concurrent infections have been shown to increase risk of transplant rejection via enhanced innate immune activation and increased T cell alloreactivity. In some cases, these…
2016 American Transplant Congress
Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs.
M. Tonsho,¹ G. Benichou,¹ R. Yu,¹ S. Boskovic,¹ R. Colvin,^1,2 E. Farkash,² R.-N. Smith,² J. Allan,^1,4 A. Cosimi,¹ T. Kawai,^1,3 J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA; ³Department of Surgery, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
(BACKGROUND)Cardiac tolerance in nonhuman primates (NHPs) has been induced for the first time by kidney co-transplantation in combination with donor bone marrow infusion when the…
2016 American Transplant Congress
B Lymphocyte-Induced Maturation Protein-1 Promotes Allograft Survival via Modulation of T Cell Development.
A. Wang,¹ C. Loh,^1,3,4 S.-J. Chen,² C.-H. Lin,¹ H.-K. Sytwu,² S.-H. Chuang,¹ F.-C. Wei.^1,4
¹VCA; PRS Dept., CGMH, Taoyuan, Taiwan; ²Department of Microbiology and Immunology, NDMC, Taipei, Taiwan; ³Division of Surgery and Interventional Science, University College London, London, United Kingdom; ⁴College of Medicine, Chang Gung University, Taoyuan, Taiwan.
*Equal contributionPurposeVascularized composite allotransplantation (VCA) is a promising new field in plastic surgery. Skin is known to be the most immunogenic component of a composite…
2016 American Transplant Congress
Exome Sequencing and HLA-Independent Prediction of Long-Term Kidney Allograft Function.
L. Mesnard,^1,3,6 T. Muthukumar,^2,9 M. Burbach,² C. Li,² H. Shang,⁴ D. Dadhania,^2,3 J. Lee,^2,3 V. Sharma,² J. Xiang,⁴ M. Carmagnat,⁵ C. Suberbielle,⁵ N. Ouali,⁶ E. Rondeau,^6,1 J. Friedewald,⁸ M. Abecassis,⁷ M. Suthanthiran,^2,9 F. Campagne.³
¹UMR1155, INSERM, Paris, France; ²Division of Nephrology and Hypertension, New York Presbyterian Hospital, New York; ³Department of Physiology and Biophysics, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY; ⁴Genomics Core Facility, Weill Cornell Medical College, New York, NY; ⁵Laboratoire d'histocompatibilité Hôpital Saint Louis, APHP, Paris, France; ⁶Service des Urgences Néphrologiques et Transplantation Rénale, APHP, Paris, France; ⁷Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁸Northwestern University Feinberg School of Medicine, Chicago, IL; ⁹Department of Transplantation Medicine, Weill Cornell Medical College, New York, NY.
Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. We asked whether information outside of the HLA loci can…
2016 American Transplant Congress
Stratification of Kidney Transplant Recipients into Those with Low and High Alloreactive T-Cells May Allow Safe Conversion to mTOR-Inhibitor-Based Immunosuppression.
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
ZEUS and Herakles study randomized kidney transplant recipients (KTRs) to either continue cyclosporine or convert to everolimus posttransplantation with favorable long-term outcomes in the conversion…
2016 American Transplant Congress
Alloimmunity Through Non-HLA Epitopes in Kidney Transplantation.
R. Reindl-Schwaighofer,¹ A. Kainz,¹ B. Cole,² J. van Setten,² K. Jelencsics,¹ B. Keating,² R. Oberbauer.¹
¹Department of Nephrology, Medical University of Vienna, Vienna, Austria; ²Transplant Division, University of Pennsylvania, Philadelphia, PA.
Introduction: An unexpected diversity in the human genome has been identified including more than 2,500 nonsynonymous single nucleotide polymorphisms (nsSNP) and up to 20 homozygous…
2015 American Transplant Congress
Controlling Alloreactive B Cell Responses in Sensitized Recipients With CTLA-4Ig
J. Chen,¹ Q. Wang,¹ D. Yin,¹ V. Vu,¹ R. Sciammas,² A. Chong.¹
¹Depart of Surgery, University of Chicago, Chicago; ²Immunobiology Transplant Center, Houston Methodist Research Institute, Houston.
Sensitized recipients are defined by the presence of pre-transplant donor-specific antibodies and have significantly poorer graft outcomes compared to unsensitized recipients despite efforts to desensitize.…
2015 American Transplant Congress
Virus Induced CD28 Down-Regulation as a Potential Driver of Costimulation Blockade Resistant Rejection
D. Mou,¹ J. Espinosa,¹ L. Stempora,² J. Kwun,² N. Iwakoshi,¹ A. Kirk.²
¹Surgery, Emory University, Atlanta, GA; ²Surgery, Duke University, Durham, NC.
Belatacept, a B7-specific fusion protein, blocks CD28-B7 costimulation and prevents kidney allograft rejection. However, it is ineffective in a sizable minority of patients. Although T…
2015 American Transplant Congress
Enhanced Requirement for TNF Signaling on Low Affinity Memory CD8+ T Cells During Heterologous Immunity
S. Krummey,¹ C.-W. Chen,¹ D. Liu,¹ M. Wagener,¹ B. Evavold,² C. Larsen,¹ M. Ford.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²Microbiology and Immunology, Emory University, Atlanta, GA.
Heterologous immunity, defined as a process during which microbe-specific T cells cross-react with allogeneic antigen and mediate graft rejection, is recognized as a significant barrier…
2015 American Transplant Congress
T Cell C5a Receptor (C5aR) Signaling Regulates T Follicular Helper Cell (Tfh) Induction
D. Verghese, P. Heeger.
Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.
Tfh cells, in part via IL-6 dependent production of IL-21, are specialized providers of B cell help. Extending previous work in which we showed that…