2016 American Transplant Congress
Immunologic Basis for Immunocloaking.
1BREONICS Inc., Watervliet, NY; 2Plastic Surgery, University of Utrecht, Utrecht, Netherlands.
A novel organ-specific immunomodifying therapy referred to as immunocloaking (IC) provides protection from early allograft rejection without immunosuppressive drugs. The IC binds to the surfaces…2016 American Transplant Congress
The Distance Between Us: The Landscape of Recipient-Specific Loss-of-Function in Solid Organ Transplantation and Association with Rejection-Free Graft Survival.
Purpose: This study aims to comprehensively identify genes that are inactivated in both copies in transplant recipients but not in their respective donors, uncovering a…2016 American Transplant Congress
Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.
Surgery, MGH/Harvard Medical School, Boston, MA.
T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…2016 American Transplant Congress
A P2X7R Mutation with Hypermetabolic T Cells, Th1/Th17 Skewing and Reduced Cardiac Allograft Survival.
Background. The purinergic receptor-7 (P2X7R), primarily expressed on lymphocytes, senses ATP released extracellularly during cell damage and regulates T cell activation.Methods. In 640 heart transplant…2016 American Transplant Congress
Indirect Allo-Antigen Stimulation Identifies the Presence of Either Regulatory IL-10 or of Effector Cytokines IFN-g, IL-21, IL-17a Production by Human Blood Allo-Reactive Memory TFH and TCONV CD4+ T Cells.
Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA.
Background: It is well accepted that human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. While our previous analysis showed…2016 American Transplant Congress
Mechanisms of Alloantigen-Specific Regulation After Donor Specific Transfusion and Costimulatory Blockade in YFP-Foxp3/TdTomRed-Ebi3 Marker Mice.
Background: In mice, donor specific transfusion (DST) plus anti-CD40L costimulatory blockade (MR-1) treatment is a standard and successful protocol to induced donor-specific transplant tolerance. Hypothesis:…2015 American Transplant Congress
Diabetic Kidney Transplant Recipients: Impaired Infection Control and Alloreactivity
New onset diabetes after transplant (NODAT) has been associated with an increased risk of infection and sepsis. Previous studies, however, failed to identify differences in…2015 American Transplant Congress
Anti-Donor T-Cell Immunity Is a Continuum Immune Process Favouring Subclinical Rejection After Kidney Transplantation
Subclinical T-cell mediated rejection (sc-TCR) accounts for a major cause of kidney allograft loss and is unexpectedly found in a rather important number of protocol…2015 American Transplant Congress
Innate Immune Memory to Allogeneic Non-Self
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
A hallmark of adaptive immunity is the generation of long-lived, antigen-specific memory T, B, and NK lymphocytes that mount strong anamnestic (recall) responses to previously…2015 American Transplant Congress
Histologic Patterns of C4d Associated With Acute Antibody Mediated Rejection of the Lung Allograft
Pathology, UT Southwestern Medical Center, Dallas, TX.
The diagnosis of antibody mediated rejection (AMR) of the lung allograft still represents a diagnostic challenge for pathologist and transplant physicians alike. The morphologic and…
American Transplant Congress abstracts