2016 American Transplant Congress
Vascular Endothelial Cell Activation by Mitochondria Links Innate and Adaptive Immune Responses to Allograft Injury.
Surgery, Duke University Medical Center, Durham, NC.
Vascular endothelial cells (ECs) are an initial barrier between allografts and the host immune system and play an important role in initiating allograft rejection. Increasing…2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…2016 American Transplant Congress
Direct Alloimmunity Is Driven by Recipient APCs Displaying Donor MHC Molecules.
We have studied the trafficking of donor passenger leukocytes and donor MHC presentation in the lymphoid organs of mice having received an MHC-mismatched skin or…2016 American Transplant Congress
mTORC2 Negatively Regulates Dendritic Cell (DC) Metabolism and the Allostimulatory Function of Donor DCs in Organ Transplantation.
The mechanistic target of rapamycin (mTOR) is a kinase that functions in at least two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play…2016 American Transplant Congress
Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.
Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA.
Concurrent infections have been shown to increase risk of transplant rejection via enhanced innate immune activation and increased T cell alloreactivity. In some cases, these…2016 American Transplant Congress
Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs.
(BACKGROUND)Cardiac tolerance in nonhuman primates (NHPs) has been induced for the first time by kidney co-transplantation in combination with donor bone marrow infusion when the…2015 American Transplant Congress
Differential Role of PI3K Subunits Gamma and Delta in Regulatory T Cells Homeostasis in Allotransplantation
Renal/Transplant Research Center, Brigham and Women's Hospital, Boston, MA.
Targeting survival pathways that differentially suppress effector T cells (Teff) while sparing regulatory T cells (Tregs) is key in devising novel tolerogenic protocols in transplantation.…2015 American Transplant Congress
Bidirectional Regulation and IL35 Surface Expression By Treg Cells
Surgery, University of Wisconsin, Madison, WI.
Background: Pre-transplant regulation on the donor side(toward the recipient), as well as the recipient side(toward the donor) promotes long-term graft survival of a kidney allo-graft…2015 American Transplant Congress
Dramatic Primary Expansion of Indirect CD4 T Cells to Allogeneic APCs In Vivo
An ongoing question regarding the primary allograft response is the relative contribution of the 'direct' (donor MHC-restricted) versus 'indirect' (host MHC-restricted) pathways of T cell…2015 American Transplant Congress
Diabetes Mellitus Predicts Outcome in Obesity After Kidney Transplantation
Obesity has been associated with an increased risk of graft loss and death after kidney transplantation. The role of cellular immunity in obese kidney transplant…
American Transplant Congress abstracts