Articles tagged "Allorecognition"

2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
J. Mattke¹, M. Plunk¹, R. R. Kane¹, B. Naziruddin²
¹Baylor University, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
2022 American Transplant Congress
Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc
L. ZHANG¹, X. LI¹, J. LIU¹, H. WEI¹, C. LI¹, A. HUANG², C. ZHENG¹, Q. LIU¹
¹Department of Biochemistry, Southern University of Science and Technology, Shenzhen, China, ²Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…
2022 American Transplant Congress
Understanding the Heterogeneity of Alloreactive Natural Killer (NK) Cell Function in Kidney Transplant Recipients
D. Ruan, M. Fribourg, N. Chun, P. Cravedi, A. Horowitz, P. Heeger
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Emerging evidence indicates that human NK cells are a heterogeneous population of lymphocytes that are activated upon ligation of one or more activating receptors…
2022 American Transplant Congress
Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets
J. Warunek¹, A. Lucas², L. R. Mathews², M. Oberbarnscheidt², F. Lakkis², H. Turnquist²
¹Immunology, Thomas E. Starzl Transplantation Institute, University at Pittsburgh, Pittsburgh, PA, ²Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…
2022 American Transplant Congress
Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression
K. Lee, F. Qiang, K. Deng, R. Matheson, J. Lei, C. LeGuern, J. Markmann
Center for Transplantation Sciences, Boston, MA
*Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
2022 American Transplant Congress
NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile
E. Bailly¹, C. Macedo¹, K. Louis², X. Gu¹, B. Ramaswami¹, M. Lucas¹, C. Bentlejewski¹, A. Zeevi¹, P. Randhawa¹, C. Lefaucheur², D. Metes¹
¹Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Paris, France
*Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…
2022 American Transplant Congress
Detection of Alloreactive CD8+ T Cell Responses and the Immunopeptidome That Elicits Their Activation
A. B. Morris, X. Zhang, E. V. Peek, A. Hadley, C. Larsen
Emory University, Atlanta, GA
*Purpose: T cell-mediated rejection results in graft dysfunction and contributes to premature failure. Due to the complexity of the TCR:pMHC interaction, prediction of alloreactive T…
2022 American Transplant Congress
Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection
M. Cano¹, D. Zhou², C. Chen³, K. Pugh⁴, D. Byers¹, D. Kreisel⁵, R. Hachem¹, A. Gelman⁵
¹Pulmonary and Critical Care, Washington University, Saint Louis, MO, ²Surgery, Washington University, Saint Louis, MO, ³Pulmonary and Critical Care, UT Southwestern Medical Center, Dallas, TX, ⁴Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, ⁵Surgery and Immunology and Pathology, Washington University, Saint Louis, MO
*Purpose: Bronchiolitis obliterans syndrome (BOS) remains a major cause of death after lung transplantation. Unfortunately, we lack effective treatments for BOS as the mechanisms by…
2022 American Transplant Congress
DEPTOR: A Novel Endothelial-Specific Regulator of Cell-Intrinsic Anti-Inflammation Following Transplantation
C. Testini¹, S. Bose¹, K. Liu¹, S. Kong¹, E. Flynn¹, M. Miovski¹, J. Leyva-Rangel¹, M. Laplante², J. Wedel¹, D. M. Briscoe¹
¹Boston Children's Hospital and Harvard Medical School, Boston, MA, ²Laval University, Quebec, QC, Canada
*Purpose: Recent studies have highlighted a paradigm whereby the maintenance of normal tissue homeostasis and the prevention of chronic inflammation is dependent on the active…
2022 American Transplant Congress
Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation
A. Dangi¹, I. Husain², N. Natesh³, X. Shen³, J. Kwun⁴, X. Luo⁵
¹Medicine, Duke University Medical Center, Durham, NC, ²Duke University Medical Center, Durham, NC, ³Biomedical Engineering, Duke University, Durham, NC, ⁴Duke Transplant Center, Durham, NC, ⁵Duke University School of Medicine, Durham, NC
*Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…

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