2022 American Transplant Congress
Donor-Specific Hyporesponsiveness Following Kidney Transplantation is Explained by Progressive Loss of Donor-Reactive Polyfunctional Cd4+ Effector Memory T Cells
Internal Medicine, Erasmus MC, Rotterdam, Netherlands
*Purpose: After kidney transplantation, donor-specific hyporesponsiveness (DSH) develops which is defined as a lowered response of alloreactive T cells to donor antigen while retaining response…2022 American Transplant Congress
Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells
*Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…2022 American Transplant Congress
Identification of Highly-Effective Donor-Reactive CD4+CD8αlo T Cells in CTLA4Ig-Treated Renal Allograft Recipient Monkeys
*Purpose: Potent CD4+CD8αlo effector T cells have been reported in transplant (tx) patients. . We evaluated the incidence and function of CD4+CD8αloT cells in renal…2022 American Transplant Congress
Are Changes in Clinical Practice Reflected in Gene Expression Profiling Scores After Heart Transplantation?
1CareDx, Brisbane, CA, 2Stanford University, Stanford, CA
*Purpose: AlloMap (AM) is a peripheral blood gene expression profiling (GEP) tool used for the assessment of acute cellular rejection in heart transplant recipients (HT).…2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…2022 American Transplant Congress
Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc
*Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…2022 American Transplant Congress
Understanding the Heterogeneity of Alloreactive Natural Killer (NK) Cell Function in Kidney Transplant Recipients
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Emerging evidence indicates that human NK cells are a heterogeneous population of lymphocytes that are activated upon ligation of one or more activating receptors…2022 American Transplant Congress
Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets
*Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…2022 American Transplant Congress
Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression
Center for Transplantation Sciences, Boston, MA
*Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…2022 American Transplant Congress
NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile
*Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…
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