ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Allorecognition"

  • 2022 American Transplant Congress

    DEPTOR: A Novel Endothelial-Specific Regulator of Cell-Intrinsic Anti-Inflammation Following Transplantation

    C. Testini1, S. Bose1, K. Liu1, S. Kong1, E. Flynn1, M. Miovski1, J. Leyva-Rangel1, M. Laplante2, J. Wedel1, D. M. Briscoe1

    1Boston Children's Hospital and Harvard Medical School, Boston, MA, 2Laval University, Quebec, QC, Canada

    *Purpose: Recent studies have highlighted a paradigm whereby the maintenance of normal tissue homeostasis and the prevention of chronic inflammation is dependent on the active…
  • 2022 American Transplant Congress

    Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation

    A. Dangi1, I. Husain2, N. Natesh3, X. Shen3, J. Kwun4, X. Luo5

    1Medicine, Duke University Medical Center, Durham, NC, 2Duke University Medical Center, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Duke Transplant Center, Durham, NC, 5Duke University School of Medicine, Durham, NC

    *Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…
  • 2022 American Transplant Congress

    High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity in Humans

    S. Moshkelgosha, A. Xiang, K. Bei, I. Hon, S. Juvet

    University Health Network, Toronto, ON, Canada

    *Purpose: Accurate measurement of T cell alloreactivity may allow prediction of graft outcome and the selection of patients for immunosuppression optimization. Current technologies cannot reliably…
  • 2022 American Transplant Congress

    Donor-Specific Hyporesponsiveness Following Kidney Transplantation is Explained by Progressive Loss of Donor-Reactive Polyfunctional Cd4+ Effector Memory T Cells

    A. C. van der List, N. H. Litjens, M. Klepper, F. Prevoo, M. G. Betjes

    Internal Medicine, Erasmus MC, Rotterdam, Netherlands

    *Purpose: After kidney transplantation, donor-specific hyporesponsiveness (DSH) develops which is defined as a lowered response of alloreactive T cells to donor antigen while retaining response…
  • 2022 American Transplant Congress

    Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells

    K. Iwasaki1, T. Tomosugi2, T. Sekiya3, H. Hamana4, Y. Miwa1, K. Futamura2, M. Okada2, T. Hiramitsu2, N. Goto2, S. Narumi2, Y. Watarai2, H. Kishi4, M. Okumura5, S. Ashimine5, K. Ishiyama5, T. Kobayashi5

    1Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, 2Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 3Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, 4Department of Immunology, University of Toyama, Toyama, Japan, 5Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
  • 2022 American Transplant Congress

    Identification of Highly-Effective Donor-Reactive CD4+CD8αlo T Cells in CTLA4Ig-Treated Renal Allograft Recipient Monkeys

    M. Kubo, K. Sasaki, L. Lu, V. Vujevich, A. Thomson, M. Ezzelarab

    Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Potent CD4+CD8αlo effector T cells have been reported in transplant (tx) patients. . We evaluated the incidence and function of CD4+CD8αloT cells in renal…
  • 2022 American Transplant Congress

    Are Changes in Clinical Practice Reflected in Gene Expression Profiling Scores After Heart Transplantation?

    T. Wolf-Doty1, K. K. Khush2, J. J. Teuteberg2

    1CareDx, Brisbane, CA, 2Stanford University, Stanford, CA

    *Purpose: AlloMap (AM) is a peripheral blood gene expression profiling (GEP) tool used for the assessment of acute cellular rejection in heart transplant recipients (HT).…
  • 2022 American Transplant Congress

    Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression

    J. Mattke1, M. Plunk1, R. R. Kane1, B. Naziruddin2

    1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX

    *Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
  • 2022 American Transplant Congress

    Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc

    L. ZHANG1, X. LI1, J. LIU1, H. WEI1, C. LI1, A. HUANG2, C. ZHENG1, Q. LIU1

    1Department of Biochemistry, Southern University of Science and Technology, Shenzhen, China, 2Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…
  • 2022 American Transplant Congress

    Understanding the Heterogeneity of Alloreactive Natural Killer (NK) Cell Function in Kidney Transplant Recipients

    D. Ruan, M. Fribourg, N. Chun, P. Cravedi, A. Horowitz, P. Heeger

    Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Emerging evidence indicates that human NK cells are a heterogeneous population of lymphocytes that are activated upon ligation of one or more activating receptors…
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