2015 American Transplant Congress
Rejection of an Allograft Through Non-MHC Antigens Does Not Translate to the Rejection of a Different Allograft from the Same Donor in Mixed Chimeras
We previously showed that tolerance, induced by mixed chimerism in mice, is antigen-specific: tolerance of heart and skin allografts is dependent on Foxp3+ cells that…2015 American Transplant Congress
Pretransplant Antibodies Against Angiotensin II Type 1 Receptor in Renal Transplantation: Preliminary Data from the KNOW-KT Study
BackgroundThe antibodies (Abs) against angiotensin II type 1 receptor (AT1R) have been suggested as a risk factor for graft failure and acute rejection. However, incidence…2015 American Transplant Congress
TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…2015 American Transplant Congress
Allogeneic Mature Human Monocyte-Derived Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in an IL-2-Independent Manner
IntroductionExpansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different…
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