ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Alloantigens"

  • 2015 American Transplant Congress

    Rejection of an Allograft Through Non-MHC Antigens Does Not Translate to the Rejection of a Different Allograft from the Same Donor in Mixed Chimeras

    K. Shinoda,1 C. Chase,1 P. Russell,1 J. Madsen,1 R. Colvin,2 A. Alessandrini.1

    1Transplant Center, Massachusetts General Hospital, Boston, MA; 2Pathology, Massachusetts General Hospital, Boston, MA.

    We previously showed that tolerance, induced by mixed chimerism in mice, is antigen-specific: tolerance of heart and skin allografts is dependent on Foxp3+ cells that…
  • 2015 American Transplant Congress

    Pretransplant Antibodies Against Angiotensin II Type 1 Receptor in Renal Transplantation: Preliminary Data from the KNOW-KT Study

    K. Huh,1 J. Lee,1 Y. Park,2 Y. Kim,1 C. Ahn.3

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

    BackgroundThe antibodies (Abs) against angiotensin II type 1 receptor (AT1R) have been suggested as a risk factor for graft failure and acute rejection. However, incidence…
  • 2015 American Transplant Congress

    TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection

    Q. Ding, K. Mohib, D. Rothstein.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.

    We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…
  • 2015 American Transplant Congress

    Allogeneic Mature Human Monocyte-Derived Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in an IL-2-Independent Manner

    N. Litjens,1 K. Boer,1 J. Zuijderwijk,1 M. Klepper,1 A. Peeters,1 E. Prens,2 W. Verschoor,1 R. Kraaijeveld,1 Z. Ozgur,3 M. van den Hout-van Vroonhoven,3 W. van IJcken,3 C. Baan,1 M. Betjes.1

    1Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; 2Dermatology and Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands; 3Erasmus Center for Biomics, Erasmus Medical Center, Rotterdam, Netherlands.

    IntroductionExpansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different…
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