2021 American Transplant Congress
hlaR,” a Simplified Interface for the HLA Matchmaker Tool
1Surgery, Emory University, Atlanta, GA, 2Pathology, Emory University, Atlanta, GA
*Purpose: Functional epitopes, or eplets, represent a set of amino acids within three angstroms of one another that may not be sequentially contiguous but are…2021 American Transplant Congress
Iguratimod Reduce Panel Reactive Antibody in High Mismatched Renal Transplant Recipients: A Retrospective Propensity Score-Matched Study
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: To evaluate the clinical efficacy and safety of iguratimod (IGU) for reducing panel reactive antibody (PRA) in high mismatched renal transplant recipients.*Methods: Eligible recipients…2021 American Transplant Congress
Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone
*Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…2021 American Transplant Congress
Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome
*Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…2021 American Transplant Congress
Epigenetic & Functional Changes Associated with Alloreactive Memory CD8 T Cell Subsets in Liver Transplant Patients
1University of Pittsburgh Medical Center, Pittsburgh, PA, 2UPMC, Pittsburgh, PA
*Purpose: Donor-specific allo-reactive memory CD8 T cells play a pivotal role in allo-immunity and represent a major hurdle against tolerance induction in solid organ transplantation.…2020 American Transplant Congress
The Addition of Splenectomy to Simultaneous Liver Kidney Transplantation Improves Class II DSA Clearance in Sensitized Patients
Department of Transplantation, University of Wisconsin, Madison, WI
*Purpose: The liver allograft clears class I donor specific antibody (DSA) more effectively than class II DSA. Persistent class II DSA in simultaneous liver kidney…2020 American Transplant Congress
Risk Factors for Antibody-Mediated Rejection after Adult Liver Transplantation with Preformed Donor-Specific Antibodies: A Single Center Experience
Div. of HBP Surgery and Transplantation, Dept. of Surgery, Kyoto University, Kyoto, Japan
*Purpose: In general, preformed donor-specific antibodies (pDSAs) can lead to an increased risk of antibody-mediated rejection (AMR); however, their prevalence, risk factors, and the efficacy…2020 American Transplant Congress
Infectious Tolerance Depends Upon the ‘Exokine’ IL35
*Purpose: Interleukin-35 (IL35) is an immunosuppressive cytokine composed of Ebi3 and p35 subunits. Yet the form(s) that IL35 assumes and its role in infectious tolerance,…2020 American Transplant Congress
Anticipated Observations: The Role of DQ Antigen Frequencies among Donors and Recipients in a Pediatric Renal Transplant Cohort
*Purpose: Donor specific HLA antibodies (DSA) that develop in the face of donor-recipient HLA mismatches are well-established independent predictors of graft loss in solid organ…2020 American Transplant Congress
Human, Monkey Transplant Tolerance and IL35 “Exokine
1University of Wisconsin, Madison, WI, 2Surgery, University of Wisconsin, Madison, WI
*Purpose: Studies in B6 (H2b) mice tolerized to CBA (H2k) have shown that induced allospecific Tregs make 2 very different forms of immunoregulatory cytokines: 1)…
- 1
- 2
- 3
- …
- 7
- Next Page »