ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Alloantigens"

  • 2020 American Transplant Congress

    The Addition of Splenectomy to Simultaneous Liver Kidney Transplantation Improves Class II DSA Clearance in Sensitized Patients

    V. Fleetwood, D. Aufhauser, C. Papageorge, K. Janek, L. Hidalgo, B. Welch, R. Redfield, J. Mezrich

    Department of Transplantation, University of Wisconsin, Madison, WI

    *Purpose: The liver allograft clears class I donor specific antibody (DSA) more effectively than class II DSA. Persistent class II DSA in simultaneous liver kidney…
  • 2020 American Transplant Congress

    Risk Factors for Antibody-Mediated Rejection after Adult Liver Transplantation with Preformed Donor-Specific Antibodies: A Single Center Experience

    T. Tajima, K. Hata, J. Kusakabe, H. Miyauchi, T. Anazawa, T. Ito, S. Uemoto

    Div. of HBP Surgery and Transplantation, Dept. of Surgery, Kyoto University, Kyoto, Japan

    *Purpose: In general, preformed donor-specific antibodies (pDSAs) can lead to an increased risk of antibody-mediated rejection (AMR); however, their prevalence, risk factors, and the efficacy…
  • 2020 American Transplant Congress

    Infectious Tolerance Depends Upon the ‘Exokine’ IL35

    W. J. Burlingham1, J. A. Sullivan1, Y. Tomita2, E. Jankowska-Gan1, D. Lema1, S. Hong3, D. A. Vignali4

    1Surgery, University of Wisconsin, Madison, WI, 2Surgery, Tokai University, Tokyo, Japan, 3Pharmacy, University of Wisconsin, Madison, WI, 4Immunology, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Interleukin-35 (IL35) is an immunosuppressive cytokine composed of Ebi3 and p35 subunits. Yet the form(s) that IL35 assumes and its role in infectious tolerance,…
  • 2020 American Transplant Congress

    Anticipated Observations: The Role of DQ Antigen Frequencies among Donors and Recipients in a Pediatric Renal Transplant Cohort

    S. Gattis1, R. George2, R. Liverman3, A. Serluco3, R. Garro2, J. Figueroa2, R. A. Bray2, H. M. Gebel2, H. C. Sullivan2

    1Emory Healthcare, Atlanta, GA, 2Emory University School of Medicine, Atlanta, GA, 3Children's Healthcare of Atlanta, Atlanta, GA

    *Purpose: Donor specific HLA antibodies (DSA) that develop in the face of donor-recipient HLA mismatches are well-established independent predictors of graft loss in solid organ…
  • 2020 American Transplant Congress

    Human, Monkey Transplant Tolerance and IL35 “Exokine

    W. J. Burlingham1, E. Jankowska-Gan2, D. Lema2, J. H. Fechner2, J. A. Sullivan2, D. B. Kaufman2

    1University of Wisconsin, Madison, WI, 2Surgery, University of Wisconsin, Madison, WI

    *Purpose: Studies in B6 (H2b) mice tolerized to CBA (H2k) have shown that induced allospecific Tregs make 2 very different forms of immunoregulatory cytokines: 1)…
  • 2020 American Transplant Congress

    The Potential Significance of ABO Genotyping for Donor Selection in Kidney Transplantation

    Y. Zhou1, W. Deng1, Y. Wang1, N. Cui1, Y. Wu1, J. Xu1, S. Fu1, L. Xiao1, H. Liu1, F. Xiong2, Y. Miao1

    1Department of Organ Trasplantation, Nanfang Hospital, Guangzhou, China, 2Southern Medical University, Guangzhou, China

    *Purpose: The ABO blood group system is clinically important in kidney transplantation, but ABO genotyping fails to attract sufficient attention in China. We identified one…
  • 2020 American Transplant Congress

    Lims1 Gene and Risk of T-Cell Mediated Rejection in Kidney Transplant Recipients

    Y. Caliskan1, G. Karahan2, S. Mirioglu3, Y. Ozluk4, R. Ouseph1, H. Yazici3, H. Randall5, F. Savran Oguz6, A. Turkmen3, M. S. Sever3, K. Lentine1

    1Division of Nephrology, Saint Louis University, Saint Louis, MO, 2Immunohematology, Leiden University Medical Center, Leiden, Netherlands, 3Division of Nephrology, Istanbul Faculty of Medicine, Istanbul, Turkey, 4Department of Pathology, Istanbul Faculty of Medicine, Istanbul, Turkey, 5Center for Abdominal Transplantation, Saint Louis University, Saint Louis, MO, 6Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul, Turkey

    *Purpose: Recent advances have provided new insights into the pathogenesis of kidney allograft rejection caused by additional antigens associated with genetic risk variant of LIM…
  • 2020 American Transplant Congress

    Pregnancy Alloimmunization Increases the Clonality of the Endogenous Treg Repertoire

    K. Krupp, E. Lewis, R. Xu, P. Porrett

    University of Pennsylvania, Philadelphia, PA

    *Purpose: Pregnancy is a common immune sensitizing event, which creates an access barrier to organ transplantation and can impact transplant outcomes. While most research has…
  • 2020 American Transplant Congress

    Activated CD27+CD21– Subset Dominate the Memory B Cell Response During Antibody-Mediated Rejection of Kidney Allografts

    K. Louis1, E. Bailly1, C. Macedo1, M. Marrari1, M. Yamada1, P. Randhawa1, A. Zeevi1, C. Lefaucheur2, D. Metes1

    1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Inserm UMR 976, Paris, France

    *Purpose: The role of alloreactive memory B (mB) cells in the pathogenesis of antibody-mediated rejection (ABMR) is increasingly recognized. Yet, a comprehensive characterization of mB…
  • 2019 American Transplant Congress

    MHC Molecule-Ablated Human Endothelial Cells Form Alloimmune-Evasive Microvessels

    J. Merola1, M. Reschke2, L. Qin1, S. Spindler1, R. W. Pierce3, T. D. Manes4, G. Li1, L. Bracaglia2, N. Kirkiles-Smith4, T. Baltazar4, W. Saltzman2, G. T. Tietjen1, G. Tellides1, J. S. Pober4

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, 3Pediatrics, Yale School of Medicine, New Haven, CT, 4Immunobiology, Yale School of Medicine, New Haven, CT

    *Purpose: “Off the shelf” tissue-engineered organs will require use of allogeneic cell sources. Allogeneic human endothelial cells (ECs), necessary for organ perfusion, can initiate graft…
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