Articles tagged "Alloantigens"

2016 American Transplant Congress
B Lymphocyte-Induced Maturation Protein-1 Promotes Allograft Survival via Modulation of T Cell Development.
A. Wang,¹ C. Loh,^1,3,4 S.-J. Chen,² C.-H. Lin,¹ H.-K. Sytwu,² S.-H. Chuang,¹ F.-C. Wei.^1,4
¹VCA; PRS Dept., CGMH, Taoyuan, Taiwan; ²Department of Microbiology and Immunology, NDMC, Taipei, Taiwan; ³Division of Surgery and Interventional Science, University College London, London, United Kingdom; ⁴College of Medicine, Chang Gung University, Taoyuan, Taiwan.
*Equal contributionPurposeVascularized composite allotransplantation (VCA) is a promising new field in plastic surgery. Skin is known to be the most immunogenic component of a composite…
2016 American Transplant Congress
Tissue Priming of Plasmacytoid Dendritic Cells Enhances Their Phagocytosis and Lowers the Threshold for Subsequent Toll-Like Receptor 7/9 Activation.
J. Ruben,¹ G. Garcia-Romo,¹ E. Breman,¹ S. van der Kooij,¹ A. Redeker,² R. Arens,² C. van Kooten.¹
¹Nephrology, Leiden University Medical Centre, Leiden, Netherlands; ²Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.
Plasmacytoid dendritic cells (pDC) have a pivotal role in clearing viral infections, and can regulate tolerance or immunity depending on their activation status. We have…
2016 American Transplant Congress
Natural Killer Cells Display Functional and Receptor Diversity in Response to Alloantigen.
O. Hatton,¹ T. Shawler,¹ C. Blish,² O. Martinez,¹ S. Krams.¹
¹Division of Abdominal Transplantation, Dept. of Surgery, Stanford University, Stanford; ²Dept of Medicine, Stanford University, Stanford.
Natural killer (NK) cells play an important role in the first-line defense against tumor and virus-infected cells. Although “missing-self” suggests NK cells would target foreign…
2016 American Transplant Congress
Ex Vivo Expansion and Functional Characterization of Human Alloantigen-Specific Regulatory T Cells.
J. Mathew,¹ S. McEwen,¹ I. Konieczna,¹ X. Huang,¹ J. He,¹ R. Kornbluth,² J. Miller,¹ L. Gallon,¹ J. Leventhal.¹
¹Surgery - Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Multimeric Biotherapeutics, Inc, La Jolla, CA.
Purpose: Regulatory T cells (Tregs) have been associated with clinical transplant tolerance and they have been shown to prolong graft survival in animal models without…
2016 American Transplant Congress
Alemtuzumab Is Safe and Effective Induction Therapy in Highly Sensitized (HS) Pediatric Patients Undergoing Transplantation.
I. Kim,¹ J. Choi,¹ A. Vo,¹ A. Kang,¹ M. Toyoda,¹ J. Mirocha,² E. Kamil,¹ S. Louie,¹ O. Galera,¹ S. Jordan,¹ D. Puliyanda.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics Core, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Studies show that alemtuzumab, a potent lymphocyte-depleting agent, is well-tolerated in pediatric renal transplantation. We report on the use of alemtuzumab induction in HS…
2016 American Transplant Congress
The Distance Between Us: The Landscape of Recipient-Specific Loss-of-Function in Solid Organ Transplantation and Association with Rejection-Free Graft Survival.
B. Cole,^1,2,5 J. van Setten,^3,5 B. Keating.^1,4,5
¹Department of Surgery, The Penn Transplant Institute, Philadelphia, PA; ²Center for Clinical Epidemiology and Biostatistics, The Institute for Biomedical Informatics, Philadelphia, PA; ³Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands; ⁴Department of Surgery, Division of Transplant, the Children's Hospital of Philadelphia, Philadelphia, PA; ⁵The Omics Working Group, iGeneTRAiN Consortium, Philadelphia, PA.
Purpose: This study aims to comprehensively identify genes that are inactivated in both copies in transplant recipients but not in their respective donors, uncovering a…
2015 American Transplant Congress
Rejection of an Allograft Through Non-MHC Antigens Does Not Translate to the Rejection of a Different Allograft from the Same Donor in Mixed Chimeras
K. Shinoda,¹ C. Chase,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.¹
¹Transplant Center, Massachusetts General Hospital, Boston, MA; ²Pathology, Massachusetts General Hospital, Boston, MA.
We previously showed that tolerance, induced by mixed chimerism in mice, is antigen-specific: tolerance of heart and skin allografts is dependent on Foxp3+ cells that…
2015 American Transplant Congress
Pretransplant Antibodies Against Angiotensin II Type 1 Receptor in Renal Transplantation: Preliminary Data from the KNOW-KT Study
K. Huh,¹ J. Lee,¹ Y. Park,² Y. Kim,¹ C. Ahn.³
¹Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; ²Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea; ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
BackgroundThe antibodies (Abs) against angiotensin II type 1 receptor (AT1R) have been suggested as a risk factor for graft failure and acute rejection. However, incidence…
2015 American Transplant Congress
TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection
Q. Ding, K. Mohib, D. Rothstein.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…
2015 American Transplant Congress
Allogeneic Mature Human Monocyte-Derived Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in an IL-2-Independent Manner
N. Litjens,¹ K. Boer,¹ J. Zuijderwijk,¹ M. Klepper,¹ A. Peeters,¹ E. Prens,² W. Verschoor,¹ R. Kraaijeveld,¹ Z. Ozgur,³ M. van den Hout-van Vroonhoven,³ W. van IJcken,³ C. Baan,¹ M. Betjes.¹
¹Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; ²Dermatology and Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands; ³Erasmus Center for Biomics, Erasmus Medical Center, Rotterdam, Netherlands.
IntroductionExpansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different…