Articles tagged "Alloantigens"

2016 American Transplant Congress
Alemtuzumab Is Safe and Effective Induction Therapy in Highly Sensitized (HS) Pediatric Patients Undergoing Transplantation.
I. Kim,¹ J. Choi,¹ A. Vo,¹ A. Kang,¹ M. Toyoda,¹ J. Mirocha,² E. Kamil,¹ S. Louie,¹ O. Galera,¹ S. Jordan,¹ D. Puliyanda.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics Core, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Studies show that alemtuzumab, a potent lymphocyte-depleting agent, is well-tolerated in pediatric renal transplantation. We report on the use of alemtuzumab induction in HS…
2016 American Transplant Congress
The Distance Between Us: The Landscape of Recipient-Specific Loss-of-Function in Solid Organ Transplantation and Association with Rejection-Free Graft Survival.
B. Cole,^1,2,5 J. van Setten,^3,5 B. Keating.^1,4,5
¹Department of Surgery, The Penn Transplant Institute, Philadelphia, PA; ²Center for Clinical Epidemiology and Biostatistics, The Institute for Biomedical Informatics, Philadelphia, PA; ³Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands; ⁴Department of Surgery, Division of Transplant, the Children's Hospital of Philadelphia, Philadelphia, PA; ⁵The Omics Working Group, iGeneTRAiN Consortium, Philadelphia, PA.
Purpose: This study aims to comprehensively identify genes that are inactivated in both copies in transplant recipients but not in their respective donors, uncovering a…
2016 American Transplant Congress
Tracking of Endogenous Graft-Reactive Tregs Reveals Their Peripheral Enrichment During Transplantation Tolerance.
J. Young,¹ J. Chen,¹ M. Miller,¹ D. Yin,¹ J. Moon,² M.-L. Alegre,¹ A. Chong.¹
¹Surgery and Medicine, University of Chicago, Chicago, IL; ²Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA.
Purpose: Our goal for this study was to determine the relative fates of endogenous Foxp3- conventional (Tconv) and Foxp3+ regulatory T cells (Tregs) specific for…
2016 American Transplant Congress
Role of Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Osteomyocutaneous Allotransplantation Under Combined Costimulation Blockade.
M. Anggelia,¹ H.-Y. Cheng,¹ Y.-L. Wang,¹ W.-Y. Chuang,¹ C.-H. Lin,¹ G. Brandacher,² F.-C. Wei,¹ C.-H. Lin.¹
¹Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: The role of regulatory T cells (Tregs) in allograft tolerance has been studied using various transplant models, but the mechanism in vascularized composite allotransplantation…
2016 American Transplant Congress
Profiling Metabolic Differences Between Graft- vs. Pathogen-Elicited CD8⁺ T Cell Responses.
A. Karp, M. Wagener, J. Robertson, M. Ford.
Emory University, Atlanta.
The challenge of immune modulation in transplantation is to inhibit pathologic alloreactivity while minimizing off-target toxicities and preserving protective immunity. Data have emerged demonstrating the…
2016 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy to Prevent T Cell Activation and Effector Functions.
K. Ayasoufi,¹ N. Kohei,¹ G. Farr,² P. McGuirk,² M. Pelletier,² R. Fairchild,¹ A. Valujskikh.¹
¹Cleveland Clinic, Cleveland; ²Aeromics LLC, Cleveland.
Aquaporin 4 (AQP4) belongs to the family of integral transmembrane proteins highly permeable to water. We have previously reported that blocking AQP4 with small molecule…
2015 American Transplant Congress
Detection of Donor Specific HLA-Ab (DSA) Against Native HLA Molecules Expressed On Donor Cell Surface to Eliminate False Positive DSA in Luminex Single Antigen Beads (LMX-SAB)
G. Chen, L. Lin, D. Tyan.
Pathology, Stanford University, Palo Alto, CA.
Introduction:The LMX-SAB has been extensively used for DSA virtual crossmatch (VXM) to predict actual crossmatch (AXM). The extreme pH and harsh chemical reaction conditions used…
2015 American Transplant Congress
Bortezomib Treatment in Antibody Mediated Rejection After Kidney Transplantation
J. Lee,¹ J. Lee,¹ B. Kim,² Y. Park,³ M. Ju,¹ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; ²Department of Internal Medicine, Yonsei University Health System, Seoul, Republic of Korea; ³Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea.
BackgroundSeveral studies demonstrated bortezomib therapy for antibody-mediated rejection (AMR) in renal transplants. However, the treatment efficacy according to target antigen or occurrence time of AMR…
2015 American Transplant Congress
The Effect of Compatibility of ABO Blood Type Antigens on Graft Survival of Intestinal Transplants
J. Cai,¹ A. Qing,² G. Wu,³ M. Everly,¹ P. Terasaki.¹
¹Terasaki Foundation Lab, Los Angeles; ²Lincoln High School, Stockton; ³The 4th Military Medical University, Xi-An, China.
Due to the introduction of new immunosuppressive agents and development of pre- and post-transplant patient management, ABO blood group incompatibility is no longer considered an…
2015 American Transplant Congress
Immunologic, Proangiogenic and Neurogenic Assessment of Allogenic Epineurium of the Human Peripheral Nerve for Potential Application in Prevention of Neuroma Formation
A. Klimczak,¹ K. Futoma,² A. Jundzill,³ D. Patrzalek,⁴ M. Siemionow.⁵
¹Clinical Immunology Department, Institute of Immunology and Experimental Therapy PAS, Wroclaw, Poland; ²Wroclaw Research Centre EIT+, Wroclaw, Poland; ³Regenerative Medicine Tissue Engineering Department, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland; ⁴Department of Surgery, 4th Military Clinical Hospital, Wroclaw, Poland; ⁵Department of Orthopaedics, The University of Illinois at Chicago, Chicago, IL.
Purpose: Transplantation of epineural sheath may support nerve regeneration after traumatic nerve injuries. Unsolved problem after nerve injury is painful neuroma formation. Natural biologic material,…