Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Introduction: Studies show that alemtuzumab, a potent lymphocyte-depleting agent, is well-tolerated in pediatric renal transplantation. We report on the use of alemtuzumab induction in HS pediatric kidney transplant.
Methods: 50 renal transplants were performed from 1/2009-12/2014. 15 HS patients received IVIg/Rituximab for desensitization with alemtuzumab induction (15-30mg, 1 dose), while 35 nonsensitized patients received anti-IL-2R (2 doses). Graft survival and infections were compared between 2 groups.
Results: All HS patients had received a prior transplant and were older. Patient survival was 100% and graft outcomes were similar with mean 1-year creatinine of 1.03±0.45 vs. 0.99±0.6, p=0.48. White blood cell (WBC) and absolute lymphocyte count (ALC) were significantly lower in alemtuzumab group at 30 days, p<0.0001, and at 1 year, p=0.026 and p=0.001, respectively. There was no significant difference in bacterial, viral (viremia defined as >50 copies/PCR), or fungal infections over 5 years.
Conclusions: Alemtuzumab induction with desensitization was well-tolerated and effective in HS pediatric patients. Although significant suppression of WBC and ALC up to 1 year post-transplant was observed, there was no significant increase in infections.
|Variable||Alemtuzumab (N=15)||Percent||IL-2R (N=35)||Percent||P-Value|
|Age, Median (IQR)||18 (14 – 19)||14 (5 – 17)||0.012|
|Serum creatinine 12 months||1.03±0.45||0.99±.60||0.48|
|Day 30||4.30±2.17||9.28±3.22||< 0.0001|
|Day 30||0.15±0.16||3.94±2.26||< 0.0001|
CITATION INFORMATION: Kim I, Choi J, Vo A, Kang A, Toyoda M, Mirocha J, Kamil E, Louie S, Galera O, Jordan S, Puliyanda D. Alemtuzumab Is Safe and Effective Induction Therapy in Highly Sensitized (HS) Pediatric Patients Undergoing Transplantation. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Kim I, Choi J, Vo A, Kang A, Toyoda M, Mirocha J, Kamil E, Louie S, Galera O, Jordan S, Puliyanda D. Alemtuzumab Is Safe and Effective Induction Therapy in Highly Sensitized (HS) Pediatric Patients Undergoing Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/alemtuzumab-is-safe-and-effective-induction-therapy-in-highly-sensitized-hs-pediatric-patients-undergoing-transplantation/. Accessed March 2, 2021.
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