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Articles tagged "Alloantibodies"

  • 2015 American Transplant Congress

    MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation

    C. Burghuber,1,2 J. Kwun,1 A. Gibby,1 N. Iwakoshi,1 S. Knechtle.1

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria.

    [Background] Sensitization before transplantation and de novo alloantibodies affect a significant number of patients awaiting kidney transplantation. The type of anti-HLA antibody varies with subgroups…
  • 2015 American Transplant Congress

    Outcome of Bortezomib/Plasmapheresis for the Sensitized Patient Awaiting Heart Transplant

    J. Patel, N. Reinsmoen, M. Kittleson, D. Dilibero, F. Liou, D. Chang, M. Hamilton, L. Czer, F. Esmailian, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: Allosensitization of patients (pts) awaiting heart transplantation is a significant challenge as it prolongs the time to transplant, increases wait-list mortality and increases risk…
  • 2015 American Transplant Congress

    Cognate Events in Antibody- Vs. T Cell-Mediated Rejection: A Molecular Perspective

    M. Parkes,1 P. Halloran,1 L. Hidalgo.2

    1Department of Medicine, University of Alberta, Edmonton, AB, Canada; 2Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.

    AIM: The cognate event in antibody-mediated rejection (ABMR) is NK cell FcR engagement; T cell mediated rejection (TCMR) uses TCR engagement. Understanding the molecular changes…
  • 2015 American Transplant Congress

    Blocking CD40/CD154 Co-Stimulation Prevents Acute Antibody-Mediated Renal Allograft Rejection Induced by Memory CD4 T Cells

    V. Gorbacheva, R. Fan, A. Valujskikh.

    Immunology, The Cleveland Clinic, Cleveland, OH.

    Immunosuppression-resistant alloreactive memory CD4 T cells induce robust responses against organ transplants. In murine heart allograft recipients donor-reactive memory CD4 T cells provide help for…
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