ATC Abstracts

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Articles tagged "Alloantibodies"

  • 2015 American Transplant Congress

    Impact of Positive Crossmatch Due to Non-HLA Antibodies on Graft Outcomes in Renal Transplantation

    S. Kuten, S. Patel, G. Land, T. Eagar, R. Knight, J. Loucks, L. Gaber, A. Gaber.

    Houston Methodist Hospital, Houston, TX.

    It is widely recognized that a positive allogeneic crossmatch (+alloXM) due to pre-existing human leukocyte antigen (HLA) antibodies is associated with early rejection episodes. However,…
  • 2015 American Transplant Congress

    Alloantibody-Dependent Macrophage-Mediated Hepatocellular Damage Is Dependent on FcγRI, FcγRIII, and Reactive Oxygen Species

    J. Zimmerer, X. Liu, A. Blaszczak, C. Wright, T. Pham, G. Bumgardner.

    Dept of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.

    Alloantibodies (alloAb) play a critical role in rejection after transplantation. Despite this, the cellular mechanisms contributing to alloAb-mediated allograft damage are not well understood. Using…
  • 2015 American Transplant Congress

    Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts

    M. Tonsho,1 G. Benichou,1 R. Smith,2 R. Colvin,2 J. Madsen.1,3

    1MGH Transplant Center, Massachusetts General Hospital, Boston, MA; 2Pathology, Massachusetts General Hospital, Boston, MA; 3Cardiac Surgery, Massachusetts General Hospital, Boston, MA.

    Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…
  • 2015 American Transplant Congress

    Burden of Early Antibody-Mediated Rejection (AMR): Complications, Resource Utilization and Cost-Differential in Treatment of AMR

    R. Banga,1 C. Schinstock,1 A. Boscoe,4 M. Hathcock,3 W. Kremers,3 M. Stegall.2

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; 2Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; 3Division of Biostatistics, Mayo Clinic, Rochester, MN; 4Health Outcomes Research, Alexion Pharmaceuticals, Cheshire, CT.

    Early antibody-mediated rejection (AMR) is common in positive crossmatch kidney transplants (+XMKTx). The current study determined the complications, resource utilization and cost associated with early,…
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