ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Alloantibodies"

  • 2016 American Transplant Congress

    Inconsistent HLA Antibody Reactivity Detected with Different Solid-Phase Assays.

    A. Jaramillo,1 L. Nelson,1 Y. Desmarteau,1 B. Labuda,2 K. Barrios,2 J. Lunz,2 R. Heilman,3 M. Pando.1

    1Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ; 2Gift of Hope Organ & Tissue Donor Network, Itasca, IL; 3Department of Medicine, Mayo Clinic, Phoenix, AZ.

    Precise determination of HLA antibodies is essential for patients awaiting transplantation. HLA antigens that are recognized by a patient are listed in UNOS as unacceptable…
  • 2016 American Transplant Congress

    Pediatric Heart Transplantation Across a Positive Cross-Match Is Associated with High Rates of AMR but No Difference in Short Term Graft Loss, Dysfunction and Death (CTOTC-04 study).

    S. Webber,1 L. Addonizio,2 E. Blume,3 A. Dipchand,4 R. Shaddy,5 B. Feingold,6 C. Canter,7 D. Hsu,8 W. Mahle,9 A. Zeevi,6 K. Much,10 D. Ikle,10 H. Diop,11 J. Odim, MD, PhD, for CTOTC-04 Investigators.11

    1Vanderbilt, Nashville; 2Columbia Univ., NYC; 3Boston Children's, Boston; 4Sick Kids, Toronto, Canada; 5CHOP, Philadelphia; 6CHP of UPMC, Pittsburgh; 7Washington Univ., St. Louis; 8Children's Hospital, Montefiore, NYC; 9CHOA, Atlanta; 10Rho, Chapel Hill; 11NIAID/NIH, Bethesda.

    Sensitization is common in pediatric heart transplant (HT) candidates. Waitlist mortality is high if a prospective -ve CDC-crossmatch (XM) is required, but HT across a…
  • 2016 American Transplant Congress

    Alloantibody Suppression by Bruton Tyrosine Kinase Antagonist Ibrutinib Is Associated with a Moderate Splenic B-Cell Reduction.

    N.-N. Chai, I. Kim, S. Jordan, A. Klein, G. Wu.

    Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background Bruton tyrosine kinase (Btk) is specifically required for activation of the B-cell antigen receptor signaling pathway that contributes to the initiation and maintenance of…
  • 2016 American Transplant Congress

    Prognosis Value of the Presence and Persistence of C1q Binding Anti-HLA Antibodies in Acute Antibody-Mediated Rejection in Kidney Transplantation.

    E. Bailly,1 B. Proust,2 M. Giral,3 V. Vuiblet,4 V. Chatelet,5 E. Morelon,6 P. Malvezzi,7 S. Caillard,8 B. Barrou,9 L. Couzi,10 J. Sayegh,11 C. Mousson,12 D. Anglicheau,13 P. Grimbert,14 M. Hazzan,15 G. Mourad,16 R. Purgus,17 P. Westeel,18 Y. Lebranchu,1,19 M. Büchler.1,19

    1CHU, Tours, France; 2EFS Centre Atlantique, Tours, France; 3ITUN, Nantes, France; 4CHU, Reims, France; 5CHU, Caen, France; 6CHU, Lyon, France; 7CHU, Grenoble, France; 8CHU, Strasbourg, France; 9Hôpital la Pitié Salpêtrière, Paris, France; 10CHU, Bordeaux, France; 11CHU, Angers, France; 12CHU, Dijon, France; 13Hôpital Necker, Paris, France; 14Hôpital Henri Mondor, Paris, France; 15CHU, Lille, France; 16CHU, Montpellier, France; 17CHU, Marseille, France; 18CHU, Amiens, France; 19Université F. Rabelais, Tours, France.

    Purpose : Longitudinal study of C1q complement fraction binding capacity of donor specific anti-HLA antibodies (DSAs) as a pronostic marker in acute antibody-mediated rejection.Methods :…
  • 2016 American Transplant Congress

    AT1R Antibodies at 1-Year Negatively Impact 5-Year Native Renal Function in Liver Transplant Recipients.

    J. O'Leary,1 A. Philippe,2 H. Heidecke,2 R. Freeman,1 L. Jennings,1 R. Catar,2 G. Klintmalm,1 D. Dragun.2

    1Baylor Simmons Transplant Insttute, Baylor University Medical Center, Dallas, TX; 2Internal Medicine, Charite, Berlin, Germany.

    Angiotensin II Type-1 Receptor (AT1R) antibodies have been associated with pulmonary hypertension, renal allograft loss, and fibrosis progression in liver allograft recipients especially if combined…
  • 2015 American Transplant Congress

    Marked Suppression of Posttransplant Alloantibody Production and Primed B cell Function In Vivo by mTOR Inhibition Compared to Calcineurin Inhibition

    C. Wright, J. Zimmerer, T. Pham, G. Bumgardner.

    Department of Surgery, CTC, The Ohio State University, Columbus, OH.

    mTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressives commonly used to suppress rejection of transplants. Despite widespread use following transplantation…
  • 2015 American Transplant Congress

    Combination of Non-HLA and HLA-DSA Antibodies Identifies Liver Transplants Recipients With Highest Risk for Fibrosis Progression and Mortality

    J. O'Leary,1 J. Cai,2 H. Heidecke,3 L. Jennings,1 A. Philippe,4 V. Harbour,1 R. Catar,4 P. Terasaki,2 G. Klintmalm,1 D. Dragun.4

    1Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX; 2Terasaki Foundation Laboratory, Los Angeles, CA; 3Celltrend, Berlin, Germany; 4Nephrology & Intensive Care Medicine, Charite Berlin, Berlin, Germany.

    Recent data has shown an increased risk of fibrosis progression in HCV viremic liver transplant (LT) recipients with HLA DSA in serum. However, the role…
  • 2015 American Transplant Congress

    Preformed Anti-HLA DP Donor Specific Antibodies Are Clinically Significant in Renal Transplantation

    V. Dibbur, M. Willicombe, P. Brookes, R. Sergeant, A. Wardle, D. Taube.

    Renal and Transplant Medicine, Imperial Healthcare NHS Trust, London, United Kingdom.

    Background: Whilst preformed [PF] anti-HLA A, B, DR and DQ donor specific antibodies [DSAbs] are associated with poorer allograft outcomes secondary to antibody mediated injury,…
  • 2015 American Transplant Congress

    Calcineurin (CNI) Exposure Reduces the Risk of Post-Transplant DSA After Deceased Donor Kidney Transplantation

    R. Pelletier, A. Rajab, G. Bumgardner, M. Henry.

    General Surgery, The Ohio State University, Columbus, OH.

    We use ATG induction with immediate rapamune (Rapa) and delayed CNI immunosuppression following kidney transplantation. Mycophenolic acid (MPA) is substituted for CNI to avoid renal…
  • 2015 American Transplant Congress

    Part II: Rates and Determinants of Progression for De Novo Donor-Specific Antibody Mediated Kidney Allograft Injury

    C. Wiebe,1,2 I. Gibson,3 D. Pochinco,2 P. Birk,4 T. Blydt-Hansen,4 J. Ho,1,5 M. Karpinski,1 A. Goldberg,4 L. Storsley,1 D. Rush,1 P. Nickerson.1,2,5

    1Medicine, University of Manitoba, Winnipeg, MB, Canada; 2Immunogenetics, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; 3Pathology, University of Manitoba, Winnipeg, MB, Canada; 4Pediatric and Child Health, University of Manitoba, Winnipeg, MB, Canada; 5Immunology, University of Manitoba, Winnipeg, MB, Canada.

    The development of de novo donor-specific antibody (dnDSA) is an independent predictor of allograft loss in renal transplantation. Rates and determinants of clinical pathologic progression…
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