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Articles tagged "Alloantibodies"

  • 2016 American Transplant Congress

    Allo-Specific Memory B Cell Recall Responses Are Dependent on B Cell Autophagy.

    J. Leventhal,1 M. Fribourg,2 J. Ni,1 P. Heeger.1

    1Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; 2Neurology, Icahn School of Medicine at Mount Sinai, NY, NY.

    B cells, and in particular, memory B cells (Bmem) are sources of donor specific antibodies (DSA) that cause allograft injury. Understanding requirements for Bmem function/survival…
  • 2016 American Transplant Congress

    Criteria for the Diagnosis of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx).

    J. Grande,1 R. Leduc,2 The DeKAF Study Group.

    1Dept. of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; 2Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.

    The presence of MVI (Banff glomerulitis "g" score and Banff peritubular capillary "ptc" score) in KTxBx, often related to antibody mediated rejection (AMR), is associated…
  • 2016 American Transplant Congress

    Utilization of Plasmapheresis and High Dose of Immunoglobulins in the Treatment of the High Level of De Novo Donor Specific Antibodies for the Successful Islet Allotransplantation.

    J. Solomina,1 Z. Tekin,1 S. Matosz,1 K. Golab,1 C. Thomas,2 J. Golebiewska,3 S. Ramachandran,1 L. Schenck,1 W. Chon,1 M. Tibudan,1 N. Marek-Trzonkowska,4 J. Millis,1 P. Witkowski.1

    1Surgery, University of Chicago, Chicago, IL; 2Medicine, University of Chicago, Chicago, IL; 3Internal Medicine, Medical University of Gdansk, Gdansk, Poland; 4Family Medicine, Medical University of Gdansk, Gdansk, Poland.

    Background.Development of donor specific antibodies (DSA) after islet transplantation has been a poor prognostic factor for graft survival, while no intervention is implemented. Here, we…
  • 2016 American Transplant Congress

    Optimized Flow Cytometry Crossmatch with Increased Sensitivity and Specificity.

    K. Barrios,1 J. Lunz,1 B. Labuda,1 D. Magas,1 D. Freedom,1 K. Szewczyk,1 M. Jendrisak,1 A. Jaramillo.1,2

    1Gift of Hope Organ & Tissue Donor Network, Itasca, IL; 2Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ.

    The flow cytometry crossmatch (FCXM) is the standard method to prevent hyperacute rejection after transplantation. Surprisingly, few technical improvements have been introduced to the FCXM…
  • 2016 American Transplant Congress

    Selective Deletion of Notch2 on B Cells Abrogates Alloantibody Production in Fully MHC-Mismatched Cardiac and Skin Transplant Models.

    N. Murakami, C. Magee, T. Borges, J. Azzi, L. Riella.

    Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA.

    Alloantibody-mediated injury remains a major challenge for the improvement of long-term graft survival and there is no effective therapy to prevent alloantibody generation post-transplant. The…
  • 2015 American Transplant Congress

    Deceased Donor and Class II Donor Specific Antibody Predict Interface Activity While Increased Age at Time of Biopsy Predicts Fibrosis in Long-Term Pediatric Liver Allografts With Normal Liver Tests: iWITH Clinical Trial

    S. Feng,1 J. Bucuvalas,2 A. Demetris,3 K. Spain,4 G. Mazariegos,3 B. Burrell,5 iWITH Investigators.6

    1UCSF, SF; 2U Cincinnati, Cincinnati; 3U Pittsburgh, Pittsburgh; 4Rho, Chapel Hill; 5ITN, Bethesda; 6NIAID/NIDDK/ITN, Bethesda.

    Background: Although multiple single centers have reported deterioration of pediatric liver grafts in the face of normal liver tests, neither risk nor mechanism is understood.Methods:…
  • 2015 American Transplant Congress

    Notch-1 Inhibition Promotes Immune Regulation in Solid Organ Transplantation

    C. Magee,1 M. Ohari,1 T. Shimizu,1 S. Ohori,1 N. Najafian,2 L. Riella.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Cleveland Clinic, Weston.

    Notch receptor signaling plays a key role in T cell activation and differentiation, though limited data exist on its importance in immune regulation. Herein, we…
  • 2015 American Transplant Congress

    A Single Center Study on Pregnacy and Allograf Function Outcomes Post Heart Transplant

    S. Adams, M. Wigger.

    Heart Transplant, Vanderbilt Medical Center, Nasvhille, TN.

    Pregnancy is a special time during a young woman's life, especially more so in those young women who are post heart transplant. The purpose of…
  • 2015 American Transplant Congress

    Pretransplant Antibodies Against Angiotensin II Type 1 Receptor in Renal Transplantation: Preliminary Data from the KNOW-KT Study

    K. Huh,1 J. Lee,1 Y. Park,2 Y. Kim,1 C. Ahn.3

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

    BackgroundThe antibodies (Abs) against angiotensin II type 1 receptor (AT1R) have been suggested as a risk factor for graft failure and acute rejection. However, incidence…
  • 2015 American Transplant Congress

    B-Cell Tolerance to Donor Alloantigens

    A. Patil, M. Climov, A. Matar, A. Musa, E. Harrington, D. Sachs, R. Duran-Struuck, C. Huang.

    Department of Surgery, Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.

    Pre-existing panel-reactive antibodies and development of donor-specific alloantibodies are known to play important roles in graft dysfunction and deterioration. Preventing and/or eliminating alloantibody responses would…
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