Articles tagged "Alloantibodies"

2016 American Transplant Congress
Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model.
J. Kwun,¹ C. Burghuber,¹ N. Iwakoshi,² A. Gibby,² S. Knechtle.¹
¹Surgery, Duke University, Durham; ²Surgery, Emory University, Atlanta.
Sensitized patients comprise a significant proportion (30%) of candidates on the waiting list for transplantation. With recent evidence that the presence of donor-specific antibodies (DSA)…
2016 American Transplant Congress
Impact of Donor Specific Antibodies on Cardiac Allograft Vasculopathy.
A. Vu,¹ A. Althouse,² A. Zeevi,³ J. Teuteberg,² M. Shullo.²
¹University of Pittsburgh Medical Center, Pittsburgh, PA; ²Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Pathology Department, University of Pittsburgh, Pittsburgh, PA.
Purpose: Cardiac allograft vasculopathy (CAV) is a significant complication after cardiac transplantation (CTX). The presence of donor specific antibodies (DSA) has been associated with an…
2016 American Transplant Congress
Factors Predicting Risk for Antibody-Mediated Rejection in Highly Sensitized Pediatric Renal Transplants.
I. Kim,¹ J. Choi,¹ A. Vo,¹ S. Louie,¹ J. Mirocha,² S. Jordan,¹ E. Kamil,¹ D. Puliyanda.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics Core, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Antibody-mediated rejection (ABMR) is a concern in highly sensitized (HS) patients (pts) receiving renal transplant (tx). We have previously published that a donor specific…
2016 American Transplant Congress
Ischemia Reperfusion Induced Murine Heart Transplant Rejection Is Complement Dependent.
N. Chun,¹ M. Zhang,² R. Fairchild,³ P. Heeger.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; ²Anesthesia, SUNY Downstate, NY, NY; ³Immunology, Cleveland Clinic, Cleveland, OH.
Increased posttransplant ischemia reperfusion injury (IRI) prevents costimulatory blockade induced heart graft survival but mechanisms linking innate and adaptive immunity are poorly understood. Based on…
2016 American Transplant Congress
Ibrutinib Suppresses Alloantibody Responses in A Mouse Model of Allosensitization: A Preliminary Report.
G. Wu, I. Kim, N.-N. Chai, A. Klein, S. Jordan.
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Ibrutinib is a Bruton tyrosine Kinase (BTK) antagonist that inhibits B cell receptor (BCR) signaling, therefore blocking B cell activation. Ibrutinib is approved by…
2016 American Transplant Congress
Frequency and Utility of Donor-Specific Antibody Testing in Simultaneous Liver Kidney Transplant.
A. Morrison,¹ D. Sawinski,² M. Kamoun,³ P. Porrett.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Medicine, University of Pennsylvania, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: The risk of antibody mediated rejection (AMR) in simultaneous liver kidney (SLK) recipients is thought to be lower than in kidney alone patients due…
2016 American Transplant Congress
De Novo DQA/DQB Donor Specific Antibodies (DSA) Is Associated with Allograft Dysfunction in Pediatric Liver Transplantation (LT).
U. Ekong, L. Bow, R. Morotti, J. Gannon, P. Valentino, P. Yoo, M. Rodriguez-Davalos, S. Emre.
Yale New Haven Transplantation Center, New Haven.
Antibody mediated rejection following LT is thought to be uncommon. Studies suggest HLA Ab that bind C1q may be deleterious to the TX allograft, &…
2016 American Transplant Congress
Renal Fibroblast Activation and Survival by Anti-MHC Class I Antibody: The Role of mTOR Signaling Pathway.
J. Chen, A. Zmijewska, R. Mannon.
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Background: Antibody-mediated injury (AMI) is an important contributor to late kidney allograft loss, and is accompanied by interstitial fibrosis (IF) and tubular atrophy (TA). However,…
2016 American Transplant Congress
Clinical Significance of C3d Binding Donor Specific Anti-HLA Antibodies (DSA) Detected by Single Antigen Beads (SAB) After Kidney Transplantation.
R. Pelletier,¹ I. Balazs,² P. Adams,³ P. Steller,³ N. DiPaola,⁴ L. Rankin,³ A. Diez,⁵ M. Henry.¹
¹Surgery/Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Discovery Research, Immucor, Inc, Stamford, CT; ³Tissue Typing Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH; ⁴Methodist Hospital, Houston, TX; ⁵Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.
A new Luminex-based SAB method detects DSA compliment fixing via C3d-binding. This study compares the clinical outcomes in kidney recipients that developed de novo DSA…
2016 American Transplant Congress
Simultaneous Pancreas/Kidney Transplantation Increases the Risk of Late-Onset BKV-Associated Nephropathy.
T. Schachtner,^1,2 M. Zaks,¹ A. Kahl,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
Infections have increased in simultaneous pancreas/kidney transplant recipients (SPKTRs) with BKV-associated nephropathy (BKVN) being the most important infectious cause of allograft loss. Comparisons of BKVN…