2016 American Transplant Congress
Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo.
Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN.
Introduction:Plasma cells (PCs) are a major source of alloantibody in transplant patients.They are resistant to current therapy. Since receptor/ligand interactions in the stromal environment are…2016 American Transplant Congress
A Novel Study to Determine the Association of Pre-Transplant Donor Specific Antibody and AT1R Antibody with Kidney Transplant Outcomes Prior to Adoption of Solid Phase Antibody Assays.
University of Wisconsin, Madison.
Background: Studies assessing the risk of pre-transplant antibodies are generally restricted to low levels of donor specific antibody (DSA). Here we analyze pre-transplant HLA DSA,…2016 American Transplant Congress
A Prospective Carfilzomib-Based Desensitization Trial: Phase 1 Results.
1U Of Cincinnati, Cincinnati; 2Mayo Clinic, Phoenix.
Carfilzomib (CFZ) is mechanistically distinct from bortezomib as it is an irreversible PI. Results from phase 1 of a CFZ desensitization (DS) trial are presentedMethods:…2016 American Transplant Congress
Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model.
[Background] Non-human primate models of sensitization provide great preclinical models to investigate the mechanisms of antibody-mediated rejection or desensitization. Now there a growing interest on…2016 American Transplant Congress
Deceased Donor Kidney Transplantation in the Setting of Positive Donor-Specific Antibodies.
1Johns Hopkins University, Baltimore; 2University of Michigan, Ann Arbor.
Recent changes to the kidney allocation system favor highly sensitized transplant candidates, resulting in these patients receiving more offers for deceased donor (DD) kidneys. Despite…2016 American Transplant Congress
Solid Phase Assay Demonstrates High Rates of Allosensitization in Pediatric Heart Recipients.
Allosensitization is a risk factor for rejection, vasculopathy and graft loss. CTOTC-04 is a prospective study assessing the impact of sensitization on a composite of…2016 American Transplant Congress
Early De Novo DSA with T Cell Mediated Rejection (TCMR) Is Associated with Allograft Dysfunction with Chronic Injury.
De novo anti-donor HLA specific antibody (DSA) detected post-renal transplantation is associated with adverse outcomes. However, the relationship between early de novo DSA and subsequent…2016 American Transplant Congress
The Bacterial Enzyme IdeS, Inhibits HLA Antibody-Mediated NK Cell Activation and Cell Cytotoxicity (ADCC) In Vitro.
Background: Antibody-mediated rejection (ABMR) is a major obstacle for successful transplantation in HLA-sensitized patients. ADCC is one of the primary mechanisms for ABMR. IdeS cleaves…2016 American Transplant Congress
Allo-Specific Memory B Cell Recall Responses Are Dependent on B Cell Autophagy.
B cells, and in particular, memory B cells (Bmem) are sources of donor specific antibodies (DSA) that cause allograft injury. Understanding requirements for Bmem function/survival…2016 American Transplant Congress
Criteria for the Diagnosis of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx).
The presence of MVI (Banff glomerulitis "g" score and Banff peritubular capillary "ptc" score) in KTxBx, often related to antibody mediated rejection (AMR), is associated…
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