2016 American Transplant Congress
De Novo DQA/DQB Donor Specific Antibodies (DSA) Is Associated with Allograft Dysfunction in Pediatric Liver Transplantation (LT).
Yale New Haven Transplantation Center, New Haven.
Antibody mediated rejection following LT is thought to be uncommon. Studies suggest HLA Ab that bind C1q may be deleterious to the TX allograft, &…2016 American Transplant Congress
Renal Fibroblast Activation and Survival by Anti-MHC Class I Antibody: The Role of mTOR Signaling Pathway.
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Background: Antibody-mediated injury (AMI) is an important contributor to late kidney allograft loss, and is accompanied by interstitial fibrosis (IF) and tubular atrophy (TA). However,…2016 American Transplant Congress
Clinical Significance of C3d Binding Donor Specific Anti-HLA Antibodies (DSA) Detected by Single Antigen Beads (SAB) After Kidney Transplantation.
A new Luminex-based SAB method detects DSA compliment fixing via C3d-binding. This study compares the clinical outcomes in kidney recipients that developed de novo DSA…2016 American Transplant Congress
Simultaneous Pancreas/Kidney Transplantation Increases the Risk of Late-Onset BKV-Associated Nephropathy.
Infections have increased in simultaneous pancreas/kidney transplant recipients (SPKTRs) with BKV-associated nephropathy (BKVN) being the most important infectious cause of allograft loss. Comparisons of BKVN…2016 American Transplant Congress
Recall Alloantibody Production Is Driven by CD138+ Cells Proliferating in the Spleens: An Indication for Long-Lived Plasma Cell Activities and Potential Therapeutic Target.
Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Donor-specific antibodies (DSA) generated in recall responses are produced by long-lived plasma cells (L-PC) residing in the bone marrows (BM). Mechanisms of L-PC activation,…2016 American Transplant Congress
Inconsistent HLA Antibody Reactivity Detected with Different Solid-Phase Assays.
Precise determination of HLA antibodies is essential for patients awaiting transplantation. HLA antigens that are recognized by a patient are listed in UNOS as unacceptable…2016 American Transplant Congress
Pediatric Heart Transplantation Across a Positive Cross-Match Is Associated with High Rates of AMR but No Difference in Short Term Graft Loss, Dysfunction and Death (CTOTC-04 study).
Sensitization is common in pediatric heart transplant (HT) candidates. Waitlist mortality is high if a prospective -ve CDC-crossmatch (XM) is required, but HT across a…2016 American Transplant Congress
Alloantibody Suppression by Bruton Tyrosine Kinase Antagonist Ibrutinib Is Associated with a Moderate Splenic B-Cell Reduction.
Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Bruton tyrosine kinase (Btk) is specifically required for activation of the B-cell antigen receptor signaling pathway that contributes to the initiation and maintenance of…2016 American Transplant Congress
Prognosis Value of the Presence and Persistence of C1q Binding Anti-HLA Antibodies in Acute Antibody-Mediated Rejection in Kidney Transplantation.
Purpose : Longitudinal study of C1q complement fraction binding capacity of donor specific anti-HLA antibodies (DSAs) as a pronostic marker in acute antibody-mediated rejection.Methods :…2016 American Transplant Congress
AT1R Antibodies at 1-Year Negatively Impact 5-Year Native Renal Function in Liver Transplant Recipients.
Angiotensin II Type-1 Receptor (AT1R) antibodies have been associated with pulmonary hypertension, renal allograft loss, and fibrosis progression in liver allograft recipients especially if combined…
- « Previous Page
- 1
- …
- 27
- 28
- 29
- 30
- 31
- …
- 40
- Next Page »