Articles tagged "Alloantibodies"

2022 American Transplant Congress
Prolonged Xeno-Kidney Graft Survival in Highly Allo-Sensitized Nonhuman Primate Using Triple-Knockout Donor Pigs with 7 Human Transgenes
M. Manook¹, D. Olaso¹, I. Anwar¹, J. Yoon¹, M. Song¹, A. B. Farris², K. Stiede³, K. Hall³, M. Youd³, S. Knechtle¹, J. Kwun¹
¹Surgery, Duke Transplant Center, Durham, NC, ²Pathology, Emory University, Atlanta, GA, ³eGenesis Inc, Cambridge, MA
*Purpose: We have previously shown using porcine kidneys from genetically modified knockout alpha 1,3-galactosyltransferase (GGTA1KO) and human decay accelerating factor transgenic (CD55Tg) pigs that compared…
2022 American Transplant Congress
Fcγ Receptor-Positive Cells Play a Critical Role in Rejection of Allogeneic Bone Marrow Cells Mediated by Anti-Donor Antibodies
H. Xu¹, Y. Huang¹, H. Xu²
¹Talaris, Louisville, KY, ²Talaris Therapeutics, Louisville, KY
*Purpose: Sensitization through prior exposure to MHC antigens results in an increased rate of graft rejection. We previously reported that humoral immunity is the primary…
2022 American Transplant Congress
Non-HLA Antibodies to G Protein-Coupled Receptors and Allograft Survival in Pediatric Kidney Transplant Recipients: Short- and Long-Term Outcomes
M. Pearl¹, L. Chen¹, P. Weng¹, E. T. Chambers², E. F. Reed³
¹UCLA, Los Angeles, CA, ²Pediatrics, Duke University, Durham, NC, ³Univ of California LA, Los Angeles, CA
*Purpose: We have recently shown that the non-HLA antibodies to angiotensin II type 1 receptor (AT1R-Ab) and endothelin-1 type A receptor (ETAR-Ab) are prevalent and…
2022 American Transplant Congress
Regulatory T Cells Suppress Memory IL-17a Production in Highly Sensitised Patients with End-Stage Renal Disease
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitised patients exhibit poorer long-term outcomes following renal transplantation compared to those non sensitised individuals. IL17-A has been associated with acute rejection. Presence…
2022 American Transplant Congress
Belatacept-Based Maintenance Immunosuppression Promoted Long-Term Antibody-Mediated Rejection Free Graft Survival After Desensitization in Sensitized Multiparous Female Recipients
M. Manook, I. Anwar, R. Schmitz, Z. Fitch, J. Yoon, A. Jackson, J. Kwun, S. Knechtle
Duke Transplant Center, Durham, NC
*Purpose: Amongst sensitized patients awaiting a transplant, females are disproportionately represented. To date, nonhuman primate (NHP) models of transplantation have relied on male animals, sensitized…
2022 American Transplant Congress
Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival
R. Steiner¹, A. M. Weijler¹, M. Muckenhuber², J. Sprent³, T. Wekerle⁴, N. Pilat¹
¹Medical University of Vienna, Vienna, Austria, ²Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria, ³Garvan Institute of Medical Research, Sydney, Australia, ⁴Vienna Gen Hosp / Medical Univ of Vienna, A-1090 Vienna, Austria
*Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…
2022 American Transplant Congress
Outcomes of Hlai Kidney Transplants in Patients with Cpra 100% After Desensitization
A. A. Vo¹, J. Tang¹, S. Williamson¹, C. Meyers¹, E. Huang¹, X. Zhang², M. Haas³, A. Peng¹, R. Najjar¹, S. Supreet¹, N. Ammerman¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Pathology, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: The KAS implementation was aimed at increasing access to kidney transplantation in highly HLA sensitized (HS) patients. However, combining desensitization (DES) + KAS could…
2022 American Transplant Congress
Impact of Belatacept on Clinical Outcomes in Lung Transplant Patients with Antibody-Mediated Rejection
L. Zaffiri, R. Hallak, S. Leonard, M. Neely, A. Hulber, H. Berry, K. A. Young, J. M. Reynolds
Duke University, Durham, NC
*Purpose: Antibody-mediated rejection (AMR) is cause of significant morbidity and mortality in lung transplant recipients (LTRs). An optimal therapeutic regimen is still lacking. Recent evidence…
2022 American Transplant Congress
Desensitization Protocol to Prevent Severe Oliguric Antibody-Mediated Rejection
H. Ishida¹, K. Unagami¹, T. Kamzawa¹, K. Omoto¹, H. Shimizu¹, K. Tanabe²
¹Tokyo Womens, Tokyo 162-8666, Japan, ²Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Antibody-mediated rejection in a case with a positive crossmatch test can be severe and result in sudden onset of oliguria and sometimes, anuria, leading…
2022 American Transplant Congress
Regulatory T and B Cell Responses Are Equally Compromised During Antibody-Mediated Rejection of Kidney Allografts
K. Louis¹, P. Fadakar², C. Macedo², M. Yamada², M. Lucas², X. Gu², A. Zeevi², P. Randhawa², C. Lefaucheur³, D. Metes²
¹Inserm U976, Human Immunology and Immunopathology, Paris, France, ²Surgery, University of Pittsburgh, Pittsburgh, PA, ³Inserm U970, Paris Translational Research Center for Organ Transplantation, Paris, France
*Purpose: Although considerable advances have been made in understanding the cellular effector mechanisms responsible for donor-specific antibody (DSA) generation leading to antibody-mediated rejection (ABMR), the…