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Articles tagged "Age factors"

  • 2015 American Transplant Congress

    Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells

    F. Krenzien,1 M. Quante,1 A. ElKhal,1 H. Uehara,1 R. Abdi,2 B. Slegtenhorst,1 H. Biefer,1 S. Tullius.1

    1Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

    Immunosenescence has broad consequences on alloimmunity and immunosuppression in the elderly may require age-adaptation. Here, we investigated the influence of aging on the effectivity of…
  • 2015 American Transplant Congress

    Age-Specific Graft Failure Rates in Pediatric Liver Transplant Recipients

    B. Foster,1 M. Dahhou,1 X. Zhang,1 V. Dharnidharka,2 J. Conway,3 V. Ng.4

    1Pediatrics, Research Institute of the McGill Univ. Health Centre, Montreal, QC, Canada; 2Pediatrics, Washington Univ., St. Louis, MO, Central African Republic; 3Pediatrics, Stollery Children's Hospital, Edmonton, AB, Canada; 4Transplant and Regenerative Medicine Center, Hospital for Sick Children, Toronto, ON, Canada.

    Graft failure risk peaks during emerging adulthood (18-25 y) in kidney transplant recipients. The association between age and graft failure risk in liver transplant recipients…
  • 2015 American Transplant Congress

    Thymic Transplantation to Determine Mechanisms of Thymic Involution: Insulin-Like Growth Factor 1 Receptor and Forkhead Box Protein N1 in the Thymus Play a Role in Maintaining the Juvenile Thymus

    K. Yamada, M. Tasaki, M. Sekijima, A. Kawai, V. Villani, T. Tanabe, I. Hanekamp, A. Shimizu, D. Sachs.

    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boton, MA.

    Thymic involution has long been associated with age-related changes of the immune system, although the cause remains unclear. We have extensively studied the role of…
  • 2015 American Transplant Congress

    Risk Factors for Graft Loss in Pediatric Renal Transplant Recipients After Transfer of Care

    B. Coyne,1,2 P. Hollen,1,2 Y. Guofen,3 K. Brayman.4

    1Department of Pediatrics, University of Virginia Health System, Charlottesville, VA; 2School of Nursing, University of Virginia, Charlottesville, VA; 3Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA; 4Department of Surgery, University of Virginia Health System, Charlottesville, VA.

    Improvements in immunosuppression and transplant surgical technique have increased the survival of children with end-stage renal disease. These patients have complex needs, and the current…
  • 2015 American Transplant Congress

    Age-Specific Graft Failure Rates in Pediatric Heart Transplant Recipients

    B. Foster,1 M. Dahhou,1 X. Zhang,1 V. Dharnidharka,2 V. Ng,3 J. Conway.4

    1Pediatrics, Research Institute of the McGill Univ. Health Centre, Montreal, QC, Canada; 2Pediatrics, Washington Univ., St. Louis, MO; 3Pediatrics, Hospital for Sick Children, Toronto, ON, Canada; 4Pediatrics, Stollery Children's Hospital, Edmonton, AB, Canada.

    Graft failure risk has been shown to peak during emerging adulthood (18-25 y) among kidney transplant recipients. The association between age and graft failure risk…
  • 2015 American Transplant Congress

    Renal Cell Carcinoma in the Native Kidney in Dialysis and Kidney Transplantation Recipients. Different Entities?

    K. Yamaçake, W. Nahas, H. Kanashiro, R. Kato, A. Bull, I. Antonopoulos, R. Falci, A. Piovesan.

    Division of Urology, Renal Transplantation Unit, University of São Paulo, São Paulo, SP, Brazil.

    Purpose: Renal Cell Carcinoma (RCC) has a high incidence in patients with acquired cystic kidney disease (ACKD) due to hemodialysis. It has been reported that…
  • 2015 American Transplant Congress

    Mitochondrial Feedback Mechanisms in Kidney Cell Senescence

    K. De Vusser,1 K. Hochstenbach,2 E. Winckelmans,2 E. Lerut,3 D. Kuypers,1 T. Nawrot,2 M. Naesens.1

    1Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; 2Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; 3Department of Pathology, University Hospitals Leuven, Leuven, Belgium.

    BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…
  • 2015 American Transplant Congress

    The Product of Donor Age and Preoperative MELD, D-MELD, Predicts Surgical Outcomes After LDLT, When Using Small Graft

    A. Tanemura, S. Mizuno, H. Kato, Y. Murata, N. Kuriyama, Y. Azumi, M. Kishiwada, M. Usui, H. Sakurai, S. Isaji.

    Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan.

    Background:Donor-recipient match is recognized as the factor well predicting recipient outcome in deceased donor liver transplantation. The aim of the present study is to evaluate…
  • 2015 American Transplant Congress

    Outcome of Kidney Transplantation from Older Living Donors: Histological Evaluation Using Zero-Time Biopsy Specimens

    K. Omoto,1 D. Toki,1 M. Okumi,1 T. Shimizu,1 H. Ishida,1 K. Honda,2 J. Koike,3 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan; 3Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan.

    OBJECTIVE: The relationship between preimplantation biopsy and graft outcome in kidney transplantations from older living donors has not been studied yet. We reviewed graft outcomes…
  • 2015 American Transplant Congress

    Excellent Outcomes With Kidney Transplantation for Patients ≥70 Years of Age

    D. Haakinson,1 K. Reddy,1 A. Moss,1 N. Katariya,1 A. Singer,1 A. Mathur,1 J. Huskey,2 H. Khamash,2 R. Heilman.2

    1Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ; 2Nephrology, Mayo Clinic Arizona, Phoenix, AZ.

    BackgroundOur aim was to determine the outcomes following kidney transplantation in recipients ≥70 years of age at the time of transplantation.Materials and MethodsWe analyzed data…
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