2016 American Transplant Congress » Poster Session A: B cells & AMR, Alloreactivity, Immune Regulation & Regulatory T Cells, T Cell Biology and Alloreactivity, Immunesuppression

Date: Saturday, June 11, 2016

Time: 5:30pm-7:30pm

Location: Halls C&D

Session Type: Poster Session

Meeting: 2016 American Transplant Congress

5:30pm-7:30pm: A Unique In Vitro Migration Model for Leukocyte Trans-Lymphatic Endothelial Migration.

Y. Xiong,¹ C. Brinkman,¹ K. Hippen,² B. Blazar,² J. Bromberg.¹

5:30pm-7:30pm: ASC-Deficient Dendritic Cells Exhibit Activation Defects and a Reduced Ability to Stimulate Allogeneic T Cells.

A. Scheinok, A. Shigeoka, S. Kasimsetty, R. Elahimehr, D. McKay.

5:30pm-7:30pm: Adiponectin Is Produced by Leukocytes Infiltrating Renal Transplants.

S. Goparaju, R. Fan, K. Keslar, N. Dvorina, W. Baldwin III.

5:30pm-7:30pm: Alloantibody Suppression by Bruton Tyrosine Kinase Antagonist Ibrutinib Is Associated with a Moderate Splenic B-Cell Reduction.

N.-N. Chai, I. Kim, S. Jordan, A. Klein, G. Wu.

5:30pm-7:30pm: Autologous BK-Specific T-Cell Lines in Kidney Transplant Recipients.

C. Lamarche,^1,2,3 O. Julie,^1,3 C. Carli,^1,3 J.-S. Delisle.^1,2,3

5:30pm-7:30pm: Bortezomib Impacts Tenascin mRNA in PBMNCs.

E. Bradley, O. Moussa, K. Twombley.

5:30pm-7:30pm: CD9+ Regulatory B Lymphocytes Control Chronic Lung Inflammation by Inducing Effector T Cell Apoptosis.

C. Brosseau,^1,2 M. Durand,¹ F. Braza,¹ E. Durand,² J. Loy,² P. Lacoste,² P. Royer,² M.-A. Cheminant,² A. Magnan,² S. Brouard.¹

5:30pm-7:30pm: CXCL12 as Innovative Immune Isolating Chemokine for Microencapsulated Allo and Xeno-Transplantation in NHPs.

M. Sremac,¹ A. Saraya,¹ O. Clemente,¹ M. Penson,¹ S. Chavan,³ N. Chronos,³ C. Schuetz,² J. Lei,² J. Markmann,² T. Brauns,¹ M. Poznansky.¹

5:30pm-7:30pm: Calcineurin Inhibitors Promote Metastasis in Post-Transplant Colorectal Cancer Through Cancer Related- Exosomes Released from Cancer Cells in TGF Beta Independent Epitheilal to Mesenquimal Transition.

V. Tubita,¹ J. Segui-Barber,⁴ M.-J. Ramírez-Bajo,¹ D. Moya-Rull,¹ P. Piselli,³ D. Verdirosi,³ F. Oppenheimer,^1,2,5 D. Serraino,⁶ H. Del Portillo,^4,7 F. Diekmann,^1,2,5 J. Campistol,^1,2,5 I. Revuelta.^1,2,5

5:30pm-7:30pm: Characterization of T Regulatory Type 1 (Tr1) Cells in Naïve and Transplanted Non-Human Primates.

R. Yu, M. Tonsho, P. Spencer, S. Bernard-Stoecklin, G. Benichou, J. Madsen.

5:30pm-7:30pm: CoCl2 Induced ER Stress Protein Mediated Cytotoxicity in FK506 Treated Hepatoma HepG2 Cells.

S. Choi, S. Chung.

5:30pm-7:30pm: Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.

J. Lee, G. Benichou.

5:30pm-7:30pm: Cross-Talk Between TLR and BCR Pathways Induces CNI-Resistance in B-Cells Responding to Blood Group A-Antigens: A Novel Paradigm for Treatment with TLR-Inhibitor for CNI-Resistant AMR.

H. Sakai, Y. Tanaka, H. Ohdan.

5:30pm-7:30pm: Early De Novo DSA with T Cell Mediated Rejection (TCMR) Is Associated with Allograft Dysfunction with Chronic Injury.

A. Cherukuri, R. Mehta, P. Sood, A. Zeevi, S. Hariharan, D. Rothstein.

5:30pm-7:30pm: Effect of Isolated Intraperitoneal Sirolimus Treatment on the Kidneys of C57BL/6 Mice.

B. Kim,^1,3 Y. Cho,³ H. Lee,³ D. Joo,^2,3 K. Huh,^2,3 M. Kim,^2,3 Y. Kim.^2,3

5:30pm-7:30pm: Eliminating Xenoantigen Expression on Swine Red Blood Cells.

Z.-Y. Wang,¹ G. Martens,¹ R. Blankenship,¹ R. Sidner,¹ P. Li,¹ J. Estrada,¹ M. Tector,² A. Tector.^1,3

5:30pm-7:30pm: End-Stage Renal Disease Does Not Impair the Large-Scale Generation of Potent Alloantigen-Specific Regulatory T Cells for Immunotherapy.

N. Litjens, K. Boer, J. Zuijderwijk, M. Klepper, A. Peeters, W. Verschoor, R. Kraaijeveld, C. Baan, M. Betjes.

5:30pm-7:30pm: Ex Vivo Expansion of Human Alloantigen-Reactive Regulatory T Cells Using Monocyte-Derived Dendritic Cells versus CD40L-Stimulated B Cells.

H. Zhang,¹ Y. Zhao,¹ L. Lu,¹ Q. Tang,² M. Ezzelarab,¹ A. Thomson.¹

5:30pm-7:30pm: Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.

M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²

5:30pm-7:30pm: HLA Antibody Clonality and Epitopes Dictate Complement Activation.

K. Thomas,¹ N. Valenzuela,¹ A. Mulder,² E. Reed.¹

5:30pm-7:30pm: IFN-γ and Contact-Dependent Cytotoxicity Are Rate-Limiting for NK Cells in a Model of Antibody-Mediated Chronic Rejection.

C. Lin,¹ R. Plenter,¹ R. Gill.²

5:30pm-7:30pm: IL2 and IL-15 Rescue TEMRA CD8 T Cells from Mitochondrial Dysfunction Associated Senescence Through a p38MAPK Dependent Pathway and Foster Their Pathogenic Potential.

G. Tilly,^1,2 M. Yap,^1,2 M. Giral,^1,2,3 C. Pecqueur,⁴ S. Brouard,^1,3 N. Degauque.^1,3

5:30pm-7:30pm: Ibrutinib Suppresses Alloantibody Responses in A Mouse Model of Allosensitization: A Preliminary Report.

G. Wu, I. Kim, N.-N. Chai, A. Klein, S. Jordan.

5:30pm-7:30pm: Immunologic Basis for Immunocloaking.

L. Brasile,¹ K. Kizjakina,¹ N. Henry,¹ B. Stubenitsky.²

5:30pm-7:30pm: Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo.

K. Bonner, N. Moore, M. Moreno Gonzales, M. Stegall.

5:30pm-7:30pm: Impact of Immunosuppressants on Inducing Regulatory T Cells in Human Allo-Immune Responses.

Y. Tanaka, H. Ohdan.

5:30pm-7:30pm: In Vitro Induction of T Regulatory Cells by Multipotent Adult Progenitor Cells.

S. Stubblefield, N. Williams, A. Ting.

5:30pm-7:30pm: Indirect Allo-Antigen Stimulation Identifies the Presence of Either Regulatory IL-10 or of Effector Cytokines IFN-g, IL-21, IL-17a Production by Human Blood Allo-Reactive Memory T_FH and T_CONV CD4⁺ T Cells.

C. Macedo, F. Paul, Y. Masaki, H. Kevin, M. Diana.

5:30pm-7:30pm: Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.

A. Konvalinka,¹ A. Chruscinski,² S. Kim,¹ K. Tinckam,¹ I. Jurisica,³ R. John.⁴

5:30pm-7:30pm: Kidney Allotransplantation Induces the Differentiation of Antigen-Experienced CD8 T Cells with Enhanced Metabolic Profiles.

G. Tilly,^1,2 M. Yap,^1,2 M. Giral,^1,2,3 S. Brouard,^1,3 C. Pecqueur,⁴ N. Degauque.^1,3

5:30pm-7:30pm: Late Renal Xenograft Failure Is Antibody-Mediated: Description of the Longest-Reported Survival in Pig-to-Primate Renal Xenotransplantation.

L. Higginbotham,¹ S. Kim,¹ D. Mathews,¹ A. Stephenson,¹ C. Breeden,¹ C. Larsen,¹ M. Ford,¹ K. Newell,¹ A. Tector,² A. Adams.¹

5:30pm-7:30pm: Learning from Cancer: Using D-Lactate for Therapeutic Immunosuppression.

U. Beier,¹ J. Jiao,¹ H. Xiao,¹ A. Angelin,² D. Wallace,² M. Levine,³ W. Hancock.⁴

5:30pm-7:30pm: Limited Efficacy of Bortezomib on Desensitization via Rapid Humoral Compensation in a Sensitized Rhesus Model.

J. Kwun,¹ C. Burghuber,¹ N. Iwakoshi,² A. Gibby,² S. Knechtle.¹

5:30pm-7:30pm: Mechanism of FK506 Induced TNF Related Apoptosis in Jurkat T Cells.

S. Chung, S. Choi.

5:30pm-7:30pm: Molecular Diagnosis of Antibody-Mediated Rejection in Routine Formalin-Fixed Paraffin-Embedded Nonhuman Primate Renal Allograft Biopsies.

B. Adam,¹ I. Rosales,² T. Oura,² R. Smith,² A. Cosimi,² T. Kawai,² R. Colvin,² M. Mengel.¹

5:30pm-7:30pm: PD-L1/PD-L2-Expressing B-1a Cells Inhibit Allo-Reactive T Cells in Mice.

T. Hirose,^1,2 Y. Tanaka,¹ H. Ohdan.¹

5:30pm-7:30pm: Pathogenic Role of Anti-HLA Antibodies on Endothelial Progenitor Cell Dysfunction of Highly Sensitized Kidney Transplanted Patients.

V. Cantaluppi,¹ S. Dellepiane,² D. Medica,² G. Tognarelli,² M. Quaglia,¹ C. Musetti,¹ A. Airoldi,¹ L. Biancone.²

5:30pm-7:30pm: Prospective Long-Term Analysis of B- and Plasma Cell Subsets in Renal Transplant Patients After Combined Treatment with Rituximab and Bortezomib in Antibody Mediated Rejection.

M. Duerr, F. Halleck, O. Staeck, L. Lehner, D. Khadzhynov, S. Eva, J. Waiser, K. Budde.

5:30pm-7:30pm: Recall Alloantibody Production Is Driven by CD138⁺ Cells Proliferating in the Spleens: An Indication for Long-Lived Plasma Cell Activities and Potential Therapeutic Target.

I. Kim, N.-N. Chai, A. Klein, S. Jordan, G. Wu.

5:30pm-7:30pm: Renal Fibroblast Activation and Survival by Anti-MHC Class I Antibody: The Role of mTOR Signaling Pathway.

J. Chen, A. Zmijewska, R. Mannon.

5:30pm-7:30pm: Resveratrol Effectively Suppress Th17 Associated Allo-Immune Responses by the Modulation of AMPK/mTOR Pathway.

B. Chung, K. Doh, J.-W. Min, K. Kim, B.-M. Kim, M.-L. Cho, C. Yang.

5:30pm-7:30pm: Sequential Analysis of Donor-Specific Antibodies and Pathological Findings Using Intravenous Immunoglobulin in a Highly Sensitized Rat Kidney Transplant Model.

Y. Sawada,¹ K. Omoto,² N. Kohei,⁴ K. Kawanishi,³ M. Okumi,² H. Ishida,² T. Kazunari.²

5:30pm-7:30pm: Single Cell Profiling of Th9 Cells Allows Identification of Functionally Different Subsets.

K. Stanko, J. Schumann, K. Vogt, S. Schlickeiser, C. Appelt, B. Sawitzki.

5:30pm-7:30pm: Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.

C. Yang,^1,4 L. Wang,³ R. Rong,^2,4 T. Zhu,^2,4 M. Xu.^2,4

5:30pm-7:30pm: The Property of Modulatory T Cells Generated by Mixed Lymphocyte Culture with CD154 Blockade.

K. Hotta, T. Oura, B. Cosimi, T. Kawai.

5:30pm-7:30pm: The Role and Mechanism of CD40/CD40L Expression on Different T-Cell Subsets.

N. Granofszky, K. Hock, B. Mahr, N. Pilat-Michalek, T. Wekerle.

5:30pm-7:30pm: The Role of B Cells in Liver Transplant Tolerance.

M. Morita,² G. Enyindah-Asonye,¹ N. Gupta,¹ J. Fung,² S. Qian,^1,2 L. Lu.^1,2

5:30pm-7:30pm: The Role of HLA Class II Antibody in Endothelial Cell Activation and Allograft Rejection.

G. Cantanhede,¹ V. Carter,² K. Giles,² J. Kirby,¹ S. Ali.¹

5:30pm-7:30pm: Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model.

J. Kwun,¹ C. Burghuber,² M. Manook,¹ A. Clark,³ D. Chen,³ S. Knechtle.¹

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