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2022 American Transplant Congress » Immunosuppression & Tolerance: Preclinical & Translational Studies

Date: Monday, June 6, 2022

Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

Session Type: Poster Abstract

Meeting: 2022 American Transplant Congress

7:00pm-8:00pm
A Novel Immunosuppressive Compound (79-6) That Targets Bcl6 Prevents the Humoral Alloresponse

R. Kraaijeveld, D. A. Hesselink, C. C. Baan

7:00pm-8:00pm
Adenosine A2A Receptor (A2AR) Agonist Apadenoson Promotes Survival in K28-hACE2 Mice and Syrian Hamsters Infected with Sars-CoV-2

P. Chhabra1, B. Mann2, M. Ma1, S. Feldman3, J. Linden4, K. L. Brayman1

7:00pm-8:00pm
Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance

R. A. Sosa1, T. Mone2, B. V. Naini1, D. B. Kohn3, E. F. Reed1, K. Wheeler2, B. Campo-Fernandez3, A. Davila3, D. J. Chaffin4, J. DiNorcia5, F. M. Kaldas5, A. Cohen2, E. Lum6, J. L. Veale7, N. M. Kogut7

7:00pm-8:00pm
Belatacept Augments Mixed Chimerism in a Novel Nonhuman Primate Kidney Transplant Tolerance Induction Protocol

S. C. Kim, C. J. Little, J. H. Fechner, P. J. Chlebeck, J. Post, A. D'Alessandro, D. B. Kaufman

7:00pm-8:00pm
CD209+ Macrophages-Mediated Immunosuppressive Effects in ADPKD Tissues

Z. Ou1, Y. Wang1, Z. Yan1, Y. Liu1, Q. Li1, Y. Fang1, J. Geng1, W. Deng1, Z. Li1, R. Xia1, W. Zeng1, J. Xu1, C. Wu2, Y. Miao1

7:00pm-8:00pm
Differences of Fk-Binding Protein 12 and P-Glycoprotein Explain the Differences in the Intracellular Tacrolimus Concentration of T Lymphocytes and Monocytes

S. Udomkarnjananun, C. Baan, B. de Winter, D. Hesselink

7:00pm-8:00pm
Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor

P. Szabolcs, E. Garchar, D. Rajasundaram, X. Chen

7:00pm-8:00pm
Evs from Patients with Amr Induce Tubular Senescence and Endmt Through Horizontal Transfer of Mirnas

R. Franzin1, A. Stasi1, F. Sallustio1, S. Bruno2, G. Merlotti3, M. Quaglia3, G. Grandaliano4, P. Pontrelli1, J. Thurman5, G. Camussi2, G. Stallone6, V. Cantaluppi3, L. Gesualdo1, G. Castellano7

7:00pm-8:00pm
Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey

H. Sakai1, E. Berglund1, S. Chaudhry1, Y. Kato1, E. Duggan1, J. Weiner1, P. Alonso-Guallart1, N. Llore1, K. Brustle1, J. Stern1, B. Piegari1, D. Ekanayake-Alper1, M. Martinez2, G. Pierre1, M. Danton1, S. Kofman1, D. Ordanes1, D. Hajosi1, J. Lefkowitch3, A. Iuga1, T. Kato4, A. Griesemer1

7:00pm-8:00pm
Il-33 Induced Regulatory Macrophages Inhibit Transplantation Immune Rejection by Inducing Tregs

J. Wu, F. Zhang, W. Wang

7:00pm-8:00pm
Immunoglobulin M (IgM) Inhibits Replication of SARS-CoV-2 In Vero E6 Cells In Vitro and Delays Disease in K18-hACE2 Mice Infected with SARSCoV-2 In Vivo

P. Chhabra1, B. Mann2, M. Ma1, S. Feldman3, K. L. Brayman1

7:00pm-8:00pm
Immunomodulatory Effects of Probiotic Bifidobacterium Bifidum with Tacrolimus and Sirolimus in Mouse Skin Graft Model

A. Han1, C. Chung2, H. Kim3, H. Ko4, E. Jo1, S. Min1, S. Kim5, H. Park5, J. Ha1

7:00pm-8:00pm
Immunosuppressants Alter Lymph Node Architecture and Create Distinct Microbiome Footprints

S. J. Gavzy1, R. Lakhan2, J. Iyyathurai2, V. Saxena2, L. Li2, B. Ma2, E. Mongodin2, J. S. Bromberg2

7:00pm-8:00pm
Impact of Changing Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function

I. Mahaparn, R. Lepping, R. N. Montgomery, R. Mukherjee, S. Billinger, W. M. Brooks, A. Gupta

7:00pm-8:00pm
Induction of Tolerance After Intestinal Transplantation in a Porcine Model

S. Merl, R. Jones, B. Chen, M. Sykes, K. Yamada, J. Weiner

7:00pm-8:00pm
NecroX-7 Ameliorate FK506-Induced Nephrotoxicity in LLC-PK1 Cells (Pig Kidney Epithelial Cells)

H. J. Jang

7:00pm-8:00pm
PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance

C. J. Little, S. C. Kim, J. Fechner, J. Post, M. Winslow, D. B. Kaufman

7:00pm-8:00pm
Protective Immunity Against a Murine Epstein-Barr Virus Homolog is Preserved During CD11b-CD154 Blockade

K. L. Alexander, D. Liu, M. L. Ford

7:00pm-8:00pm
Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression

T. Shi1, A. Burg1, K. Roskin2, J. Rush3, B. Haraldsson3, A. Shields4, R. Alloway4, E. Woodle5, D. Hildeman1

7:00pm-8:00pm
Sustained Alloantigen Exposure Reinforces Transplantation Tolerance

J. B. Allocco1, C. McIntosh1, P. Wang1, Y. Wang1, M. Miller1, H. Sattar2, D. Yin3, Z. J. Zhang4, A. Chong3, M. Alegre1

7:00pm-8:00pm
The Intracellular Tacrolimus Concentration in CD3+ T Lymphocytes and CD14+ Monocytes and Its Association with Kidney Transplant Rejection

S. Udomkarnjananun, C. Baan, B. de Winter, D. Hesselink

7:00pm-8:00pm
Tolerance of Allogeneic Kidneys with Durable (>200 Days) Multilineage Chimerism and Bone Marrow Engraftment in Cynomolgus Macaques

Y. Tomori1, Y. Hisadome1, D. Eisenson1, K. Takeuchi1, K. Okubo1, C. Huang2, D. Sachs1, M. Sykes1, K. Yamada1

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