2022 American Transplant Congress » Immunosuppression & Tolerance: Preclinical & Translational Studies

7:00pm-8:00pm

A Novel Immunosuppressive Compound (79-6) That Targets Bcl6 Prevents the Humoral Alloresponse

R. Kraaijeveld, D. A. Hesselink, C. C. Baan

7:00pm-8:00pm

Adenosine A2A Receptor (A2AR) Agonist Apadenoson Promotes Survival in K28-hACE2 Mice and Syrian Hamsters Infected with Sars-CoV-2

P. Chhabra¹, B. Mann², M. Ma¹, S. Feldman³, J. Linden⁴, K. L. Brayman¹

7:00pm-8:00pm

Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance

R. A. Sosa¹, T. Mone², B. V. Naini¹, D. B. Kohn³, E. F. Reed¹, K. Wheeler², B. Campo-Fernandez³, A. Davila³, D. J. Chaffin⁴, J. DiNorcia⁵, F. M. Kaldas⁵, A. Cohen², E. Lum⁶, J. L. Veale⁷, N. M. Kogut⁷

7:00pm-8:00pm

Belatacept Augments Mixed Chimerism in a Novel Nonhuman Primate Kidney Transplant Tolerance Induction Protocol

S. C. Kim, C. J. Little, J. H. Fechner, P. J. Chlebeck, J. Post, A. D'Alessandro, D. B. Kaufman

7:00pm-8:00pm

CD209+ Macrophages-Mediated Immunosuppressive Effects in ADPKD Tissues

Z. Ou¹, Y. Wang¹, Z. Yan¹, Y. Liu¹, Q. Li¹, Y. Fang¹, J. Geng¹, W. Deng¹, Z. Li¹, R. Xia¹, W. Zeng¹, J. Xu¹, C. Wu², Y. Miao¹

7:00pm-8:00pm

Differences of Fk-Binding Protein 12 and P-Glycoprotein Explain the Differences in the Intracellular Tacrolimus Concentration of T Lymphocytes and Monocytes

S. Udomkarnjananun, C. Baan, B. de Winter, D. Hesselink

7:00pm-8:00pm

Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor

P. Szabolcs, E. Garchar, D. Rajasundaram, X. Chen

7:00pm-8:00pm

Evs from Patients with Amr Induce Tubular Senescence and Endmt Through Horizontal Transfer of Mirnas

R. Franzin¹, A. Stasi¹, F. Sallustio¹, S. Bruno², G. Merlotti³, M. Quaglia³, G. Grandaliano⁴, P. Pontrelli¹, J. Thurman⁵, G. Camussi², G. Stallone⁶, V. Cantaluppi³, L. Gesualdo¹, G. Castellano⁷

7:00pm-8:00pm

Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey

H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, E. Duggan¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Brustle¹, J. Stern¹, B. Piegari¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, D. Hajosi¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, A. Griesemer¹

7:00pm-8:00pm

Il-33 Induced Regulatory Macrophages Inhibit Transplantation Immune Rejection by Inducing Tregs

J. Wu, F. Zhang, W. Wang

7:00pm-8:00pm

Immunoglobulin M (IgM) Inhibits Replication of SARS-CoV-2 In Vero E6 Cells In Vitro and Delays Disease in K18-hACE2 Mice Infected with SARSCoV-2 In Vivo

P. Chhabra¹, B. Mann², M. Ma¹, S. Feldman³, K. L. Brayman¹

7:00pm-8:00pm

Immunomodulatory Effects of Probiotic Bifidobacterium Bifidum with Tacrolimus and Sirolimus in Mouse Skin Graft Model

A. Han¹, C. Chung², H. Kim³, H. Ko⁴, E. Jo¹, S. Min¹, S. Kim⁵, H. Park⁵, J. Ha¹

7:00pm-8:00pm

Immunosuppressants Alter Lymph Node Architecture and Create Distinct Microbiome Footprints

S. J. Gavzy¹, R. Lakhan², J. Iyyathurai², V. Saxena², L. Li², B. Ma², E. Mongodin², J. S. Bromberg²

7:00pm-8:00pm

Impact of Changing Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function

I. Mahaparn, R. Lepping, R. N. Montgomery, R. Mukherjee, S. Billinger, W. M. Brooks, A. Gupta

7:00pm-8:00pm

Induction of Tolerance After Intestinal Transplantation in a Porcine Model

S. Merl, R. Jones, B. Chen, M. Sykes, K. Yamada, J. Weiner

7:00pm-8:00pm

NecroX-7 Ameliorate FK506-Induced Nephrotoxicity in LLC-PK1 Cells (Pig Kidney Epithelial Cells)

H. J. Jang

7:00pm-8:00pm

PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance

C. J. Little, S. C. Kim, J. Fechner, J. Post, M. Winslow, D. B. Kaufman

7:00pm-8:00pm

Protective Immunity Against a Murine Epstein-Barr Virus Homolog is Preserved During CD11b-CD154 Blockade

K. L. Alexander, D. Liu, M. L. Ford

7:00pm-8:00pm

Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression

T. Shi¹, A. Burg¹, K. Roskin², J. Rush³, B. Haraldsson³, A. Shields⁴, R. Alloway⁴, E. Woodle⁵, D. Hildeman¹

7:00pm-8:00pm

Sustained Alloantigen Exposure Reinforces Transplantation Tolerance

J. B. Allocco¹, C. McIntosh¹, P. Wang¹, Y. Wang¹, M. Miller¹, H. Sattar², D. Yin³, Z. J. Zhang⁴, A. Chong³, M. Alegre¹

7:00pm-8:00pm

The Intracellular Tacrolimus Concentration in CD3⁺ T Lymphocytes and CD14⁺ Monocytes and Its Association with Kidney Transplant Rejection

S. Udomkarnjananun, C. Baan, B. de Winter, D. Hesselink

7:00pm-8:00pm

Tolerance of Allogeneic Kidneys with Durable (>200 Days) Multilineage Chimerism and Bone Marrow Engraftment in Cynomolgus Macaques

Y. Tomori¹, Y. Hisadome¹, D. Eisenson¹, K. Takeuchi¹, K. Okubo¹, C. Huang², D. Sachs¹, M. Sykes¹, K. Yamada¹