ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Utility of Anti-Phospholipase A2 Receptor (Anti-PLA2R) ELISA Testing in Predicting Post-Transplant Idiopathic Membranous Nephropathy (IMN)

    C. VanBeek,1 D. Thomas,2 A. Jimenez,2 A. Vo,2 S. Jordan,2 M. Toyoda.2

    1Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; 2Transplant Immunology, Cedars-Sinai Medical Center, Los Angeles, CA.

    Backgound: IMN is frequently associated with autoantibodies to the podocyte antigen, PLA2R. Anti-PLA2R associated IMN is diagnosed by detecting PLA2R antigen within glomerular immune complexes…
  • 2015 American Transplant Congress

    Combined Robotic Kidney Transplantation and Sleeve Gastrectomy in Obese Recipients: Initial Results from Prospective Randomized Study

    I. Tzvetanov, G. D'Amico, G. Georgiev, H. Jeon, R. Garcia-Roca, E. Benedetti, J. Oberholzer.

    Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, IL.

    IntroductionIn many transplant centers, patients with a BMI above 40 kg/m2 are either completely excluded or required to lose weight before being considered for kidney…
  • 2015 American Transplant Congress

    Rabbit Antithymocyte Globulin Is Associated With Improved Patient and Graft Survival in Liver Transplantation. Experience With 595 Patients

    M. Montenovo,1 F. Jalikis,2 L. Meng,3 Y. Matthew,2 D. Andre,1 H. Ryan,3 R. Jorge.1

    1Surgery, University of Washington, Seattle, WA; 2Pathology, University of Washington, Seattle, WA; 3Pharmacy, University of Washington, Seattle, WA.

    BACKGROUND: Use of induction therapy in liver transplantation is debatable. We aimed to compare clinical outcomes of different induction protocols in liver transplant recipients.METHODS: Retrospective…
  • 2015 American Transplant Congress

    B Cell MicroRNA as Biomarkers for Epstein-Barr Virus Associated Post-Transplant Lymphoproliferative Disorder

    A. Harris-Arnold, V. Kaul, S. Shaffert, O. Hatton, C. Esquivel, S. Krams, O. Martinez.

    Surgery/Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA.

    Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation and is commonly associated with Epstein Barr virus (EBV) infection. EBV viral loads…
  • 2015 American Transplant Congress

    Alemtuzumab Induction Is Associated With Higher Risk of Polyomavirrus Associated Nephropathy (PVAN) in Kidney Transplant Recipients

    H. Wadei,1 H. Saull,2 C. Enderby,2 M. Mai,1 M. Prendergast,1 T. Gonwa.1

    1Transplant, Mayo Clinic, Jacksonville, FL; 2Pharmacy, Mayo Clinic, Jacksonville, FL.

    Incidence of PVAN on protocol kidney biopsies with alemtuzumab induction is unknown.Methods:The 1-year risk of PVAN was retrospectively compared between 200 consecutive primary kidney recipients…
  • 2015 American Transplant Congress

    The Losing Trifecta: Age ≥70, Deceased Donor Transplant, and Delayed Graft Function

    R. Crew, H. Fernandez, S. Mohan, G. Dube, L. Ratner, R. Sandoval, S. Patel.

    Columbia University, New York.

    INTRO: Patients ≥70 are the fastest growing part of the ESRD population. Although historically patients ≥70 have had acceptable renal transplant outcomes, in our own…
  • 2015 American Transplant Congress

    Constitutively Upregulated Expression of Complement and Matrix Transcripts in Kidney Transplant Recipients Who Develop Acute Rejection

    K. Keslar,1 J. Reid-Adam,4 E. Kwon,4 D. Hricik,5 E. Poggio,2,3 P. Heeger,4 R. Fairchild.1,3

    1Immunology, Cleveland Clinic; 2Nephrology, Cleveland Clinic; 3Glickman Urological Institute and Transplant Center, Cleveland Clinic, Cleveland, OH; 4Icahn School of Medicine, Mount Sinai, New York, NY; 5Nephrology, UH Case Medical Center, Cleveland, OH.

    Identification of kidney transplants at elevated risk of acute rejection (AR) and/or chronic injury prior to loss of kidney function (GFR) could guide therapies to…
  • 2015 American Transplant Congress

    Gender Differences in Kidney Transplant Delayed Graft Function Are Independent of Donor-Recpient Size Mismatch

    M. Levine,1 A. Thomasson,1 D. Aufhauser,1 R. Redfield,2 P. Abt,1 P. Reese.3

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Surgery, University of Wisconsin, Madison, WI; 3Medicine, University of Pennsylvania, Philadelphia, PA.

    Introduction: Superior female tolerance of ischemia reperfusion injury (IRI) relative to males has been described in animal models, but little human data are available to…
  • 2015 American Transplant Congress

    Selective Blockade of the CD28/B7/CTLA4 Pathway With Monovalent Anti-CD28 Antibodies Versus Targeting of B7 With CTLA4-Ig, in Non-Human Primate Kidney Allograft

    S. Ville,1 N. Poirier,1,2 B. Vanhove,1,2 G. Blancho.1

    1INSERM, UMR1064, ITUN, Nantes, France; 2Effimune SAS, Nantes, France.

    B7 molecules on antigen-presenting cells interact with CD28 and CTLA4 on T lymphocytes to control TCR-mediated signals. Whereas it is highly efficient to block T…
  • 2015 American Transplant Congress

    Targeting Leukocyte Integrin CD11b/CD18 With a Novel mAb Salvages Renal Function Following an Otherwise Irreversible Ischemic Insult in Cynomolgus Monkeys

    A. Cosimi,1 A. Dehnadi,1 R. Smith,2 D. Ko,1 X. Li,3 M. Arnaout.3

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA; 2Pathology, MGH, Boston, MA; 3Nephrology, MGH, Boston, MA.

    Allograft dysfunction resulting from ischemic reperfusion injury (IRI) leads to increased peri-transplant costs, morbidity, and inferior long-term survival. Leukocyte/endothelial adhesion is an important pathway contributing…
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