ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Deep Surgical Site Infections (dSSI) After Liver Transplantation (LTx): Emergence of Multiple-Drug Resistant (MDR) Pathogens

    J. Viehman,1 L. Clarke,1 R. Shields,2 C. Clancy,2,3 M. Nguyen.1,2

    1University of Pittsburgh Medical Center, Pittsburgh, PA; 2University of Pittsburgh, Pittsburgh, PA; 3VA Pittsburgh Health System, Pittsburgh, PA.

    Purpose: We described the epidemiology, microbiology and outcomes of dSSI after LTx.Methods: We performed a single center retrospective study of 332 consecutive patients undergoing LTX…
  • 2015 American Transplant Congress

    Targeting Complement Pathways During Ischemia and Reperfusion: Implications for the Prevention of Delayed Graft Function

    Z. Yu,1 S. Qi,2 M. Lasaro,1 K. Bouchard,1 C. Dow,1 K. Moore,1 Z. Wu,2 A. Barama,2 J. Xu,2 K. Johnson,1 A. Marozsan,1 Y. Wang.1

    1Pre-Clinical Sciences, Alexion Pharmaceutical Inc., Cheshire, CT; 2Department of Surgery, Hôpital Notre Dame and Université de Montréal, Montréal, QC, Canada.

    Complement system plays a critical role in ischemia-reperfusion injury (IRI), and contributes to DGF. The aim of this study was to evaluate the effects of…
  • 2015 American Transplant Congress

    Pre-Transplant Cardiac Troponin T (cTT) Is a Strong Predictor of Post Kidney Transplant Hospitalizations

    H. Amer, P. Geerdes, T. Fettes, R. Walker, E. Lorenz, F. Cosio.

    The William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.

    Identifying patients at risk of re-hospitalization will permit improved monitoring and may decrease morbidity.We examined nine objective variables at the time of transplant and their…
  • 2015 American Transplant Congress

    Significant Association Between Foxp3 Gene Polymorphism and Outcomes in HBV-Related Liver Transplant Patients

    Y. Tanaka, V. Sapana, H. Ohdan.

    Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Background: Previous studies have demonstrated that CD4+Foxp3+ regulatory T (Treg) cells regulate HBV-related disease progression. The present study investigated the association between Treg cells and…
  • 2015 American Transplant Congress

    Stable and Unstable Chimerism During Immunosuppressive Drug Withdrawal in Tolerant Recipients of HLA Matched Combined Kidney and Hematopoietic Cell Transplants

    T. Pham,1 S. Busque,1 J. Scandling,2 J. Shizuru,2 S. Asha,1 S. Strober.2

    1Surgery, Stanford University, Palo Alto, CA; 2Medicine, Stanford University, Palo Alto, CA.

    Our previous studies showed that 75-80% of HLA matched recipients of combined kidney and hematopoietic cell transplants conditioned with total lymphoid irradiation (TLI) and anti-thymocyte…
  • 2015 American Transplant Congress

    The Spleen Is the Primary Site for Breg Induction and Is Required for Anti-TIM-1 Mediated Tolerance

    K. Mohib, Q. Ding, A. Cherukuri, D. Rothstein.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.

    B cells can exhibit potent IL-10-dependent regulatory (Breg) activity. IL-10-enriched Bregs can transfer tolerance in auto and allo-immune models. We showed that TIM-1 is an…
  • 2015 American Transplant Congress

    The Role of Hemodialysis Social Networks in Transplantation: Five Year Follow Up of an Urban Hemodialysis Cohort

    A. Pai, A. Gillespie.

    Nephrology, Hypertension, and Kidney Transplantation, Temple University, Philadelphia, PA.

    Background: Racial and socioeconomic disparities are well known barriers to kidney transplantation (KT), especially among minority populations. Emerging evidence suggests social networks exist within hemodialysis…
  • 2015 American Transplant Congress

    Impact of Induction Therapy on Outcomes in HIV + Renal Transplant Recipients

    C. Kershaw,1 C. Rogers,2,4 M. Pavlakis,1,2 H. Tang,2 C. Alonso,1,2 K. Khwaja,2,3 A. Evenson,2,3 K. Raven,2,3 M. Wong.1,2

    1Medicine, Beth Israel Deaconess Medical Center (BIDMC), Boston, MA; 2The Transplant Institute, BIDMC, Boston, MA; 3Surgery, BIDMC, Boston, MA; 4Pharmacy, BIDMC, Boston, MA.

    Purpose: Kidney transplantation in HIV+ recipients has been complicated by higher than expected acute rejection rates (AR). Induction immunosuppression may or may not impact this…
  • 2015 American Transplant Congress

    Implications of Living Donor Kidney Histology, Volume and Function on Post-Donation GFR

    Z. Zaky,1 B. Lankowsky,2 S. Shah,1 L. Herlitz,1 A. Chiesa-Vottero,1 K. Wallenfelsz,1 A. Caplin,1 D. Goldfarb,1 S. Flechner,1 J. Schold,1 E. Poggio.1

    1Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH; 2CWRU School of Medicine, Cleveland, OH.

    Living kidney donor transplantation is the best modality for treating ESRD as it confers excellent outcomes to patients and it is safe for donors. Postdonation…
  • 2015 American Transplant Congress

    Multicenter Study to Develop a Novel Prediction Index for Hepatocellular Carcinoma (HCC) Recurrence After Liver Transplant (LT)

    N. Mehta,1 J. Heimbach,2 D. Harnois,3 J. Dodge,1 J. Burns,3 D. Lee,3 W. Sanchez,2 J. Roberts,1 F. Yao.1

    1UCSF, San Francisco, CA; 2Mayo Clinic, Rochester, MN; 3Mayo Clinic, Jacksonville, FL.

    Several factors have been associated with a high risk of recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT), but no reliable risk score has…
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