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American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    The Effects of High-Risk Donors and Recipients on Scientific Registry of Transplant Recipients Program-Specific Outcomes

    J. Snyder,1 N. Salkowski,1 D. Zaun,1 J. Schold,2 A. Israni,1 B. Kasiske.1

    1Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; 2Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.

    Public reporting of transplant program-specific outcomes may dissuade programs from accepting high-risk donors and recipients, and thereby restrict access to transplant. It has been proposed…
  • 2015 American Transplant Congress

    Multicenter Validation of a Molecular Diagnostic for Antibody-Mediated Rejection in Formalin-Fixed Paraffin-Embedded Human Renal Allograft Biopsies

    B. Adam,1 B. Afzali,1 N. Shah,1 K. Dominy,2 R. Gill,1 L. Hidalgo,1 P. Campbell,1 C. Roufosse,2 M. Mengel,1 B. Sis.1

    1University of Alberta, Edmonton, Canada; 2Imperial College, London, United Kingdom.

    Background: In 2013, the Banff classification adopted molecular diagnostics as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. The NanoString gene…
  • 2015 American Transplant Congress

    Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study

    F. Eskandary,1 G. Bond,1 H. Regele,2 N. Kozakowski,2 Z. Kikic,1 M. Wahrmann,1 H. Haslacher,3 R. Oberbauer,1 V. Ramassar,4 P. Halloran,4 G. Böhmig.1

    1Nephrology and Dialysis, Medical University Vienna, Vienna, Austria; 2Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria; 3Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria; 44Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

    Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…
  • 2015 American Transplant Congress

    B7-H1 Deficiency in Liver Allografts Leads to CD8-Mediated Acute Vascular Rejection

    M. Morita, D. Joyce, J. Fung, S. Qian, R. Fairchild, L. Lu.

    Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Clevland Clinic, Cleveland, OH.

    The liver is a unique organ in that it is accepted across complete MHC mismatch in allotransplantation in a number of species. The mechanisms behind…
  • 2015 American Transplant Congress

    Investigation of Myocardial Function in Pediatric Transplant Recipients

    K. Sgambat, S. Clauss, M. Lasota, A. Moudgil.

    Children's National, Washington, DC.

    Purpose: In light of the major impact of cardiovascular morbidity on long-term transplant outcomes, a prospective controlled study was conducted to investigate changes in myocardial…
  • 2015 American Transplant Congress

    Adoptive Transfer of T Cell Receptor-Transgenic (TCR-Tg) Cells Alters Endogenous Immune Responses During Acute Rejection

    M. Miller, M. Daniels, Y. Wang, D. Yin, A. Chong, M.-L. Alegre.

    University of Chicago, Chicago, IL.

    In addition to the therapeutic use of adoptive transfer of T cells to combat viral infections and malignancies in humans, adoptive transfer of T cell…
  • 2015 American Transplant Congress

    Immunoglobulin G Donor-Specific Anti-HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury

    D. Viglietti,1,2 C. Bentlejewski,3 J.-P. Duong van Huyen,4,2 D. Vernerey,5,2 O. Aubert,2 J. Verine,1 X. Jouven,2 C. Legendre,4 D. Glotz,1 A. Loupy,2,4 A. Zeevi,3 C. Lefaucheur.1,2

    1Saint-Louis Hospital, Paris, France; 2Paris Translational Research Center for Organ Transplantation - INSERM U970, Paris, France; 3University of Pittsburgh Medical Center, Pittsburgh; 4Necker Hospital, Paris, France; 5CHRU de Besançon, Besançon, France.

    Experimental and clinical data suggest that antibodies have different pathogenicities according to their IgG subclasses. We investigated the association between IgG subclasses of circulating anti-HLA…
  • 2015 American Transplant Congress

    Outcomes Associated With Carbapenem-Resistant Klebsiella Pneumoniae (CRKP) in Solid Organ Transplant (SOT) Recipients

    T. Bias,1 A. Sharma,2 G. Malat,3 D. Lee,2 A. Doyle.2

    1Dept of Pharmacy, Hahnemann University Hospital, Philadelphia; 2Dept of Medicine, Drexel University, College of Medicine, Philadelphia; 3Dept of Surgery, Drexel University, College of Medicine, Philadelphia, PA.

    Background: Infection with CRKP is emerging as an important challenge among SOT recipients. Our study aims to describe the epidemiology and clinical outcomes associated with…
  • 2015 American Transplant Congress

    Extended Analysis of Tocilizumab (anti-IL-6R) + Intravenous Immunoglobulin (IVIG) as Desensitization (DES) Agents for Reduction of Donor Specific Antibodies (DSA) in Patients Resistant to DES With IVIG + Rituximab

    A. Vo, J. Choi, I. Kim, J. Kahwaji, A. Peng, R. Villicana, S. Jordan.

    Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: IVIG+rituximab is an acceptable approach for DES with good outcomes. Despite this, ∼30% of patients fail DES, thus other approaches are needed. Options include…
  • 2015 American Transplant Congress

    Monitoring Intracellular Tacrolimus Concentration in Kidney Transplant Recipients With Stable Graft Function

    E. Bae,1 S. Han,1 S. Yang,2 J. Park,1 H. Lee,1 J. Lee,3 D. Kim,1 Y. Kim.1

    1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; 2Kidney Research Institute, Seoul National University, Seoul, Korea; 3Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.

    Background: Monitoring the intracellular concentration of immunosuppressive agents can be promising to improve and individualize clinical practice in patients receiving transplantation. However, this issue remains…
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