Am J Transplant, Volume 5, Suppl 3 Archives - Page 80 of 170 - ATC Abstracts

2015 American Transplant Congress
Efficacy and Safety of Once-Daily Everolimus With Minimized Once-Daily Tacrolimus After Liver Transplantation
P. De Simone,¹ P. Carrai,¹ L. Coletti,¹ A. Precisi,² D. Campani,³ F. Filipponi.¹
¹Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy; ²Laboratory, University of Pisa Medical School Hospital, Pisa, Italy; ³Pathology, University of Pisa Medical School Hospital, Pisa, Italy.
Background: The everolimus (EVR) pharmacokinetic profile allows for its once daily (OD) administration. We tested the efficacy and safety of a combination schedule of OD-EVR…
2015 American Transplant Congress
The Best Regimen With Rituximab for ABO-Incompatible Living Donor Liver Transplantation
H. Egawa,¹ K. Umeshita,² S. Uemoto.³
¹Surgery, Tokyo Women's Medical University, Tokyo, Japan; ²Osaka University, Suita, Japan; ³Kyoto University, Kyoto, Japan.
Rituximab made a great progress on outcomes of ABO-incompatible living donor liver transplantation (ABO-I LDLT). Although Japanese multicenter study group published efficacy and safety of…
2015 American Transplant Congress
Treatment Patterns, Healthcare Resource Utilization, and Costs in Kidney Transplant Recipients Using a Fixed Source Regimen of Tacrolimus Vs. a Variable Source Regimen
E. Lee,¹ S. Bunniran,² P. Kamble,² B. Suehs,² B. Franks,¹ J. Schwartz,¹ C. Anderson,³ G. Thal,¹ J. Spalding.¹
¹Astellas Scientific and Medical Affairs, Northbrook, IL; ²Comprehensive Health Insights, Humana, Louisville, KY; ³Humana, Louisville, KY.
BackgroundTacrolimus (TAC) has evolved to be the foundation of kidney transplant immunosuppressant protocols. However, the implications of switching between multiple formulations of TAC have not…
2015 American Transplant Congress
Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells
K. Samy, H. Xu, A. Kirk.
Surgery, Duke University Medical Center, Durham, NC.
Current induction therapy using thymoglobulin (ATG) results in nonspecific T cell depletion. We have generated a polyclonal rabbit anti-human leukocyte globulin (RALG) by immunizing rabbits…
2015 American Transplant Congress
Thymic Transplantation to Determine Mechanisms of Thymic Involution: Insulin-Like Growth Factor 1 Receptor and Forkhead Box Protein N1 in the Thymus Play a Role in Maintaining the Juvenile Thymus
K. Yamada, M. Tasaki, M. Sekijima, A. Kawai, V. Villani, T. Tanabe, I. Hanekamp, A. Shimizu, D. Sachs.
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boton, MA.
Thymic involution has long been associated with age-related changes of the immune system, although the cause remains unclear. We have extensively studied the role of…
2015 American Transplant Congress
Immunodeficiency Assessment in Pediatric Intestinal Failure Patients
J. Garcia,¹ T. Beduschi,¹ C. Biaggi,² E. Perez,² A. Tekin,¹ M. McGetrick,³ L. Cubley,¹ P. Ruiz,¹ J. Fan,¹ S. Nishida,¹ G. Selvaggi,¹ R. Vianna.¹
¹Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL; ²Pediatrics, University of Miami Miller School of Medicine, Miami, FL; ³University of Miami Miller School of Medicine, Miami, FL.
Intestinal failure (IF) is a clinical condition for which intestinal transplantation may be indicated. Patients without enteral autonomy have an increased risk of malnutrition which…
2015 American Transplant Congress
Clinical and Immunologic Risk Factors Associated With Donor-Specific Antibody (DSA) Formation Following Renal Transplantation
C. Johnson,¹ S. Park,¹ J. Schiller.²
¹Department of Surgery, Medical College of Wisconsin, Milwaukee, WI; ²Blood Center of Wisconsin, Milwaukee, WI.
Background: De novo DSA formation is emerging as an important risk factor for adverse graft outcomes following renal transplantation. Specific pretransplant risk factors for DSA…
2015 American Transplant Congress
Evaluation of Medication Regimen Complexity Over Time Following Heart Re-Transplantation
B. Bryant,¹ A. Libby,¹ R. Page,¹ J. Lindenfeld,² C. Aquilante.¹
¹University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO; ²University of Colorado School of Medicine, Aurora, CO.
Medication regimen complexity (MRC) includes many characteristics of a drug regimen. Previously, we showed that MRC is high and persists over time after primary heart…
2015 American Transplant Congress
Interleukin-17A Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function
K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Grey,⁵ C. Hope,^1,2 R. Carroll,^1,4 S. Gronthos,^3,6 P. Coates.^1,2,3,4
¹Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ³Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia; ⁴Central Northern Adelaide Renal Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ⁵Transplantation Immunology Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia; ⁶Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Interferon-gamma preactivated mesenchymal stem cells (MSC-γ) are highly immunosuppressive but immunogenic in vivo due to their inherent expression of major histocompatibility (MHC) molecules. We modified…
2015 American Transplant Congress
Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft
X. Zhang,¹ Y. Gong,² K. Jiang,² C. Wang,² T. Xia,² J. Li,² J. Wang,² J. Nie.²
¹Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; ²Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Objectives:The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. In this study we investigated if systematic…