2015 American Transplant Congress
Chest Wall,Thymus, and Heart Transplant: Pushing the Boundary of Solid Organ Allotransplantation
Objective:The last 10 years have ushered in the clinical reality of upper extremity and face transplantation with animal models and basic science evidence to support…2015 American Transplant Congress
Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…2015 American Transplant Congress
Donor-Specific Alloantibody After Positive Crossmatch Kidney Transplantation With Eculizumab (EC): Correlation With Transplant Glomerulopathy and Graft Failure
1Mayo Clinic, Rochester, MN; 2Paul Terasaki Foundation, Los Angeles, CA.
Introduction. EC (C5 blockade) reduces the incidence of early clinical acute antibody mediated rejection (AMR) after +XMKTx, but does not prevent chronic AMR. We examined…2015 American Transplant Congress
Characteristics and Outcomes of Kidneys Procured from Donors With KDPI > 80%
TRIBE Consortium, New Haven, CT.
Kidneys procured from donors with KDPI>80% are often biopsied and pumped, yet frequently discarded. The accuracy of these quality assessment tools remain controversial but contribute…2015 American Transplant Congress
The Effects of High-Risk Donors and Recipients on Scientific Registry of Transplant Recipients Program-Specific Outcomes
Public reporting of transplant program-specific outcomes may dissuade programs from accepting high-risk donors and recipients, and thereby restrict access to transplant. It has been proposed…2015 American Transplant Congress
Multicenter Validation of a Molecular Diagnostic for Antibody-Mediated Rejection in Formalin-Fixed Paraffin-Embedded Human Renal Allograft Biopsies
1University of Alberta, Edmonton, Canada; 2Imperial College, London, United Kingdom.
Background: In 2013, the Banff classification adopted molecular diagnostics as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. The NanoString gene…2015 American Transplant Congress
Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study
Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…2015 American Transplant Congress
B7-H1 Deficiency in Liver Allografts Leads to CD8-Mediated Acute Vascular Rejection
The liver is a unique organ in that it is accepted across complete MHC mismatch in allotransplantation in a number of species. The mechanisms behind…2015 American Transplant Congress
Investigation of Myocardial Function in Pediatric Transplant Recipients
Children's National, Washington, DC.
Purpose: In light of the major impact of cardiovascular morbidity on long-term transplant outcomes, a prospective controlled study was conducted to investigate changes in myocardial…2015 American Transplant Congress
Adoptive Transfer of T Cell Receptor-Transgenic (TCR-Tg) Cells Alters Endogenous Immune Responses During Acute Rejection
University of Chicago, Chicago, IL.
In addition to the therapeutic use of adoptive transfer of T cells to combat viral infections and malignancies in humans, adoptive transfer of T cell…
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