Am J Transplant, Volume 5, Suppl 3 Archives - Page 74 of 170 - ATC Abstracts

2015 American Transplant Congress
Angiopoietin-2 Associates With Graft Failure and Mortality in Renal Transplant Recipients
W. Westendorp,¹ C. Keyser,² E. van den Berg,² C. Krikke,¹ H. van Goor,³ S. Bakker,² H. Leuvenink.¹
¹Surgery, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ²Nephrology, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ³Pathology, University Medical Center Groningen, Groningen, Netherlands.
Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are involved in stabilizing the vascular endothelium and may play a role in premature mortality and graft failure in renal…
2015 American Transplant Congress
An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation
C. Falk,¹ I. Goldschmidt,² F. Mutschler,² C. Neudörfl,¹ J. Keil,¹ K. Daemen,¹ F. Lehner,³ R. Mikolajzcyk,⁴ A. Karch,⁴ U. Baumann.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Division of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany; ³Department of Visceral General and Transplant Surgery, Hannover Medical School, Hannover, Germany; ⁴Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Braunschweig, Germany.
The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…
2015 American Transplant Congress
Distinct Roles of CD137 and CD137L Bi-Directional Signaling in Candida albicans Infection
H. Cho,^1,2 J. Lee,^2,3 V. Tran,⁴ B. Kwon.^2,4
¹Department of Surgery, Ulsan University Hospital, Ulsan, Korea; ²Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea; ³Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea; ⁴School of Biological Sciences, University of Ulsan, Ulsan, Korea.
Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients, yet the cellular processes leading to this mortality remain ill-defined. Here, using genetic…
2015 American Transplant Congress
Early Steroid Withdrawal and Infection Risk in Kidney Transplant Recipients
S. Bae, L. Kucirka, C. Durand, B. Orandi, R. Avery, D. Segev.
Johns Hopkins, Baltimore, MD.
BACKGROUND: While early steroid withdrawal (ESW) is hypothesized to lower the risk of infection, previous studies failed to demonstrate this benefit. These were limited by…
2015 American Transplant Congress
Conversion from Immediate to Prolonged Release Tacrolimus Did Not Change Intra-Patient Variability in Renal Transplant Patients
T. El-Nahhas,^1,2 M. Moreton,² J. Popoola,³ S. Abat,³ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology Department, William Harvey Research Institute, Barts and The London, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St. George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St. George's University of London, London, United Kingdom.
Background. Tacrolimus has a narrow therapeutic index and is characterized by a large inter- and intra-patient variability (IPV). Variable blood tacrolimus concentrations have been shown…
2015 American Transplant Congress
Pharmacokinetics of Mycophenolic Acid (MPA) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
P. Romano,¹ F. Agena,² P. Ebner,¹ A. Triboni,² F. Ramos,² N. Galante,² F. Lemos,² N. Sumita,¹ E. David-Neto.²
¹Division of Central Laboratory, – Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Renal Transplantation Service, – Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…
2015 American Transplant Congress
A Prospective Study of Renal Function and Histological Changes in Renal Transplant Recipients With Acute Clinical and Subclinical Rejection
S. Chen,¹ R. Mehta,¹ P. Sood,¹ P. Randhawa,² N. Shah,¹ C. Wu,¹ A. Tevar,³ S. Hariharan.¹
¹Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA; ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Transplant Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Background: To study the impact on renal function and histological changes in patients(pts) with acute clinical rejection(ACR) and subclinical rejection(SCR) from 3 to 12 month(m)…
2015 American Transplant Congress
Associations Between Sirolimus Use and Outcomes After Liver Transplant for Hepatocellular Carcinoma
E. Yanik,¹ S. Chinnakotla,² A. Israni,^2,3 J. Snyder,^2,3 S. Gustafson,³ E. Engels.¹
¹Natl. Cancer Inst., Bethesda, MD; ²U. of Minnesota, Minneapolis, MN; ³Sci. Reg. of Transplant Recipients, Minneapolis, MN.
A growing fraction of U.S. liver transplants are being done for the indication of hepatocellular carcinoma (HCC). HCC recurrence after transplant remains a major concern…
2015 American Transplant Congress
Age-Specific Graft Failure Rates in Pediatric Liver Transplant Recipients
B. Foster,¹ M. Dahhou,¹ X. Zhang,¹ V. Dharnidharka,² J. Conway,³ V. Ng.⁴
¹Pediatrics, Research Institute of the McGill Univ. Health Centre, Montreal, QC, Canada; ²Pediatrics, Washington Univ., St. Louis, MO, Central African Republic; ³Pediatrics, Stollery Children's Hospital, Edmonton, AB, Canada; ⁴Transplant and Regenerative Medicine Center, Hospital for Sick Children, Toronto, ON, Canada.
Graft failure risk peaks during emerging adulthood (18-25 y) in kidney transplant recipients. The association between age and graft failure risk in liver transplant recipients…
2015 American Transplant Congress
High Incidence of Masked Hypertension in Pediatric Recipients of Stem Cell Transplantation
A. Melk,¹ D. Thurn-Valsassina,¹ B. Schmidt,² R. Beier.³
¹Pediatric Nephrology, Hannover Medical School, Hannover, Germany; ²Nephrology, Hannover Medical School, Hannover, Germany; ³Pediatric Hematology, Hannover Medical School, Hannover, Germany.
Purpose: Different from recipients of a solid organ transplant, stem cell transplantation (SCT) recipients do not receive long term immunosuppressive treatment that may cause renal…