Am J Transplant, Volume 5, Suppl 3 Archives - Page 59 of 170 - ATC Abstracts

2015 American Transplant Congress
Single Nucleotide Polymorphisms (SNPs) Associated With Acute Rejection in European American Kidney Transplant Recipients: A Genome Wide Association Study (GWAS)
A. Israni,¹ C. Dorr,¹ M. Miller,² D. Schladt,¹ K. Sanghavi,³ A. Muthusamy,¹ R. Remmel,³ W. Guan,⁴ B. Wu,⁴ W. Oetting,³ P. Jacobson,³ A. Matas,⁵ For DeKAF Genomics & GEN03 Investigators.¹
¹Medicine, MMRF, Hennepin County Medical Center, Minneapolis, MN; ²Psychology, University of MN, Minneapolis, MN; ³Pharmacy, University of MN, Minneapolis, MN; ⁴Biostatistics, University of MN, Minneapolis, MN; ⁵Surgery, University of MN, Minneapolis, MN.
Purpose: Acute rejection (AR) is associated with increased risk of allograft loss. Therefore, we conducted a GWAS to determine SNPs associated with AR in a…
2015 American Transplant Congress
Use of RNA Sequencing for Discovery of Markers of Accommodation in Surveillance Biopsies from Recipients of an ABO-Incompatible Renal Transplant
A. McLean,² K. Dominy,¹ A. Sosinsky,¹ M. Mueller,¹ J. Galliford,² T. Cook,^1,2 C. Roufosse.^1,2
¹Imperial College, London, United Kingdom; ²Imperial College Healthcare NHS Trust, London, United Kingdom.
Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…
2015 American Transplant Congress
Human Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact
E. Montanari,¹ R. Mahou,^1,2 S. Passemard,² F. Noverraz,² P. Morel,¹ R. Meier,¹ D. Bosco,¹ J. Seebach,³ C. Wandrey,² S. Gerber,² C. Gonelle-Gispert,¹ L. Buhler.¹
¹Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland; ²Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ³Division of Immunology and Allergy, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.
Background and Aim:The aim of this study was to evaluate the survival and function of human pancreatic islets co-encapsulated with human Mesenchymal Stromal Cells (MSC)…
2015 American Transplant Congress
Interactions Between Platelets and Liver Sinusoidal Endothelial Cells Initiate Liver Regeneration
J. Meyer,^1,2 E. Lejmi,² P. Fontana,^2,3 P. Morel,^1,2 C. Gonelle-Gispert,² L. Bühler.^1,2
¹Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ²Geneva Medical School, Geneva, Switzerland; ³Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland.
ObjectivesPlatelets and liver sinusoidal endothelial cells (LSEC) were shown to be important contributors to liver regeneration. Several recent studies suggested that their interactions might be…
2015 American Transplant Congress
Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury
B. Yang,¹ K. Hamelin,¹ L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ N. Patey,² M.-J. Hébert.¹
¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Université de Montréal, Montréal, Canada; ²Department of Pathology, CHU Ste-Justine Université de Montréal, Montréal, Canada.
Ischemia-Reperfusion Injury (IRI) is a significant cause of renal allograft dysfunction and a risk factor for poor long-term graft outcomes. Microvascular injury is an important…
2015 American Transplant Congress
Analysis of Patient Refusals for Transplantation
A. Reeves-Daniel,¹ A. Palanisamy,¹ G. Orlando,² J. Rogers,² G. Russell,¹ A. Farney,² J. Burkart,¹ R. Stratta,² B. Freedman.¹
¹Internal Medicine, Wake Forest University, Winston-Salem, NC; ²Surgery, Wake Forest University, Winston-Salem.
Disparities in access to the kidney transplant wait list have been described for women, African Americans (AAs), and the elderly. However, few data are available…
2015 American Transplant Congress
Kidney Donor Profile Index Variability in Donors With Dialysis Dependent Acute Kidney Injury and the Impact On Organ Allocation
A. Pai,¹ M. Ghanta,¹ S. Rao,¹ A. Gillespie,¹ S. Karhadkar,² K. Lau,² A. Di Carlo,² S. Constantinescu,¹ I. Lee.¹
¹Nephrology, Temple Univesity School of Medicine, Philadelphia, PA; ²Surgery, Temple Univesity School of Medicine, Philadelphia, PA.
Kidney Donor Profile Index (KDPI) is calculated using 10 donor variables including terminal serum creatinine (Cr) and is used in the new kidney allocation system…
2015 American Transplant Congress
High Intra-Patient Variability in Tacrolimus Trough Blood Levels Increases the Risk of Death-Censored Graft Loss After Kidney Transplantation
E. Rodrigo,¹ D. San Segundo,² J. Ruiz,¹ M. López-Hoyos,² A. Benito,¹ M. de Cos,³ Z. Albines,¹ M. Serrano,¹ M. Arias.¹
¹Nephrology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; ²Immunology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; ³Pharmacology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
Kidney graft loss rates beyond the first year showed only small improvements over past decades. Advances in maintenance immunosuppressive therapy contributed to the improvements seen…
2015 American Transplant Congress
A Retrospective Study to Describe the Epidemiology and Outcomes of Opportunistic Infections After Solid Organ Transplantation
M. Helfrich,¹ P. Dorschner,¹ M. Ison.^1,2
¹Northwestern University Transplant Research Collaborative, Chicago; ²Infectious Diseases and Organ Transplantation, Northwestern University Feinberg SoM, Chicago.
Background: Solid organ transplant (SOT) recipients are at increased risk for infections due to their complex medical conditions and use of immunosuppressive therapies. Despite significant…
2015 American Transplant Congress
Post-Transplantation Immunoadsorption Can Be Safely Withheld After ABO-Incompatible Kidney Transplantation
A. de Weerd,¹ M. van Agteren,¹ J. Ijzermans,² W. Weimar,¹ M. Betjes.¹
¹Nephrology and Kidney Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; ²Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Background: After ABO-incompatible kidney transplantation, postoperative plasma exchange (PE) or immunoadsorption (IA) is performed per protocol or depending on postoperative A/B-titers to prevent acute rejection.…