Live Donor Vs Deceased Donor Liver Transplantation Results in Identical Outcome in Recipients With Acute Liver Failure – An Important Choice for Critical Ill Patients
Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Meeting: 2015 American Transplant Congress
Abstract number: B150
Keywords: Liver failure
Session Information
Date: Sunday, May 3, 2015
Session Name: Poster Session B: Liver: Living Donors
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Introduction: Live donor liver transplantation (LDLT) is a valid alternative to deceased donor liver transplantation (DDLT) in patients suffering from acute liver failure (ALF). Rapid disease progression and high mortality of ALF patients on the LT waiting lists makes LDLT an ideal option for this patient population. Live donor work-up can be performed in a short period of time allowing faster access to transplantation.
Methods: We report the outcome of LDLT for patients suffering from ALF. From 2006-2013, all patients with ALF receiving a LDLT (n=7) at our institution were compared to all ALF patients receiving a DDLT (n=26).
Results: Both groups were comparable regarding pre-transplant ICU stay (DDLT: 1 (0-7) vs. LDLT: 1 days (0-10); p=0.38), mechanical ventilation (DDLT: 69% vs. LDLT: 57%; p=0.66), inotropic drug requirement (DDLT: 27% vs. LDLT: 43%; p=0.64) and dialysis (DDLT: 2 vs. LDLT: 0 patients; p=1). Median evaluation time for live donors was 24hr (18-72hr). LDLT vs. DDLT had similar incidence of postoperative complications (31% vs. 43%; p=0.66). No difference was detected between LDLT and DDLT patients regarding 1- (DDLT: 92% vs. LDLT: 86%), 3- (DDLT: 92% vs. LDLT: 86%), and 5- (DDLT: 92% vs. LDLT: 86%) year graft and patient survival (p= 0.63). No severe donor complication (Dindo-Clavien >3b) occurred after live liver donation.
Conclusion: ALF is a severe disease with high mortality on LT waiting lists. Therefore, LDLT is an attractive option since live donor work-up can be expedited and LT can be performed within 24hr with excellent short and long-term outcomes.
To cite this abstract in AMA style:
Goldaracena N, Sapisochin G, Echeverri J, Kaths M, Selzner N, Cattral M, Greig P, Lilly L, McGilvray I, Levy G, Ghanekar A, Renner E, Grant D, Selzner M. Live Donor Vs Deceased Donor Liver Transplantation Results in Identical Outcome in Recipients With Acute Liver Failure – An Important Choice for Critical Ill Patients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/live-donor-vs-deceased-donor-liver-transplantation-results-in-identical-outcome-in-recipients-with-acute-liver-failure-an-important-choice-for-critical-ill-patients/. Accessed February 28, 2020.« Back to 2015 American Transplant Congress