Am J Transplant, Volume 5, Suppl 3 Archives - Page 27 of 170 - ATC Abstracts

2015 American Transplant Congress
High Tolerability With Sofosbuvir-Based Direct-Acting Antiviral Therapy in Liver Transplant Recipients With Recurrent Hepatitis C
B. Osborne,¹ A. Modi,¹ M. Gautam,¹ N. Murray,¹ I. Gonzalez,² J. McAfee,² S. Gonzalez.¹
¹Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; ²Hepatology, Liver Consultants of Texas, Fort Worth, TX.
Background: Reports on efficacy, safety, and tolerability of sofobuvir-based antiviral regimens in liver transplant recipients with recurrent hepatitis C are limited. Methods: We performed a…
2015 American Transplant Congress
Everolimus-Based Immunosuppression Is Associated With a Reduced Risk of New-Onset Malignancies After Liver Transplantation
P. De Simone,¹ P. Carrai,¹ L. Coletti,¹ D. Ghinolfi,¹ D. Campani,² F. Filipponi.¹
¹Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy; ²Pathology, University of Pisa Medical School Hospital, Pisa, Italy.
Background and aim: The inhibitor of the mammalian target of rapamycin (mTOR) everolimus (EVR) has shown anti-proliferative effects in experimental and clinical models. We investigated…
2015 American Transplant Congress
The Impact of Baseline and Follow-Up Social Adaptability Index Scores on Outcomes in Kidney Transplantation
D. Taber, M. Hamedi, M. Gebregziabher, T. Srinivas, K. Chavin, L. Egede, P. Baliga.
MUSC, Charleston, SC.
Globally, socioeconomic status (SES) is a significant determinant of health outcomes, with the social adaptability index (SAI) representing a quantifiable and validated surrogate of SES.…
2015 American Transplant Congress
microRNA-494 Promotes Cyclosporine-Induced Nephrotoxicity and Epithelial to Mesenchymal Transition By Inhibiting PTEN
J. Yuan,¹ C. Benway,^1,2 J. Bagley,¹ J. Iacomini.^1,2
¹Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA; ²Sackler School of Biomedical Sciences Programs in Immunology and Genetics, Tufts University School of Medicine, Boston, MA.
Purpose: A major complication associated with cyclosporine (CsA) treatment is nephrotoxicity. MicroRNAs (miRs) have been shown to play an important role in various pathological conditions,…
2015 American Transplant Congress
Glycogen Synthase Kinase 3β Inhibition Promotes Human iTreg Differentiation and Suppressive Function
Y. Xia, H. Zhuo, Y. Lu, L. Deng, R. Jiang, L. Zhang, L. Pu, X. Wang.
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Induced regulatory T cells (iTregs) are essential to maintain immunological tolerance, immune homeostasis, and prevention of autoimmunity. Some studies suggest that glycogen synthase kinase 3β…
2015 American Transplant Congress
Long-Term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation
J. Weiner, J. Zuber, B. Shonts, S. Yang, M. Martinez, T. Kato, M. Sykes.
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
Introduction: Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation…
2015 American Transplant Congress
Gene Expression Monitoring in Pediatric Heart Transplant Recipients
C. Sutton,¹ R. Butts,² A. Burnette,³ A. Savage,² W. Uber,¹ A. Haney.¹
¹Pharmacy, Medical University of South Carolina, Charleston, SC; ²Pediatric Cardiology, Medical University of South Carolina, Charleston, SC; ³Pediatric Heart Transplant, Medical University of South Carolina, Charleston, SC.
Allomap® gene expression testing is a non-invasive screening tool approved for use in heart transplant recipients age 15 and older. Experience with Allomap® in pediatric…
2015 American Transplant Congress
Prevalence and Outcomes of Heart Transplantation in Children With Intellectual Disability
A. Wightman,¹ H. Bartlett,¹ Q. Zhao,² J. Smith.³
¹Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI; ³Pediatrics, University of Washington School of Medicine, Seattle, WA.
Background:Heart transplantation in children with intellectual disability (ID) is a controversial issue. Previous research on this population has been limited to small case reports.Objective:To describe…
2015 American Transplant Congress
Incidence and Risks Associated With Clostridium Difficile Infection in the Pediatric Solid Organ Transplantation Population: A Single-Center Retrospective Review
L. Danziger-Isakov,¹ J. Ciricillo,² S. Blum,¹ M.-O. Kim,¹ C. Liu,¹ G. Paulsen,¹ J. Courter,¹ D. Haslam.¹
¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²Xavier University, Cincinnati, OH.
Morbidity and mortality related to Clostridium difficile Infection (CDI) has increased. Adult SOT data have reported risk factors for CDI. We interrogated the epidemiology of…
2015 American Transplant Congress
Cardiosphere-Derived Cells from Cadaver Can Improve Heart Function in a Model of Non-Ischaemic Dilated Cardiomyopathy
J. Wu,^1,2 Y. Sun,^1,2 M. Tan,³ D. Chi,^1,2 M. Zhang,^1,2 K. Kang,⁴ X. Jin,⁵ B. Yu.^1,2
¹Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; ²Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ³Cardiology, The First Hospital of Fangshan District, Beijing, China; ⁴Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Objectives: Cardiosphere-derived cells (CDCs) are mainly obtained through myocardial biopsy, and could improve cardiac function and attenuate remodeling in myocardial infarction. In this study, we…