Am J Transplant, Volume 5, Suppl 3 Archives - Page 24 of 170 - ATC Abstracts

2015 American Transplant Congress
CFZ533: Assessment of Immunomodulatory Activity Following Single Doses of a Novel Anti-CD40 mAb in Healthy Volunteers
A. Slade,¹ J. Doucet,² P. Koo,¹ P. Espie,² J. Rush,² C. Tomek,³ J. Klupp.²
¹Novartis Institute for Biomedical Research, East Hanover, NJ; ²Novartis Institute for Biomedical Research, Basel, Switzerland; ³Celerion, Inc, Lincoln, NE.
Blocking the CD40-CD154 pathway has been shown to effectively prolong renal allograft survival in non-human primates. CFZ533 is a novel, fully human, Fc-silent, anti-CD40 monoclonal…
2015 American Transplant Congress
Absence of Allograft TLR4 Receptor Signaling Attenuates Early Inflammation and Promotes Survival of Allografts Subjected to Prolonged Cold Ischemic Storage
N. Kohei,¹ T. Tanaka,¹ H. Tsuda,¹ D. Kish,¹ K. Tanabe,² R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
Designing a KDPI to Assess Live Donors and Compare Them to Deceased Donors
A. Massie, D. Segev.
Johns Hopkins, Baltimore.
The Kidney Donor Profile Index (KDPI) is used to assess risk of deceased donor kidneys (DDKT) based on donor characteristics. No comparable index exists for…
2015 American Transplant Congress
APOL1 Risk Alleles in Live and Deceased Kidney Donors Are Associated With Shorter Renal Allograft Survival
M. Doshi,¹ M. Goggins,² S. Norman,³ S. Ho,⁴ C. Winkler,⁵ J. Kopp.⁶
¹Medicine, Wayne State University, Detroit, MI; ²Medicine, Henry Ford Transplant Institute, Detroit, MI; ³Medicine, University of Michigan, Ann Arbor, MI; ⁴Gift of Life, Ann Arbor, MI; ⁵NCI, NIH, Bethesda, MD; ⁶NIDDK, NIH, Bethesda, MD.
Kidneys from African American (AA) donors with two Apolipoprotein L1 (APOL1) risk alleles may be at higher risk of allograft loss after transplant. We sought…
2015 American Transplant Congress
Differential Clinical Outcomes in Kidney Transplant Recipients With De Novo C1q+ and C1q- Donor Specific Antibodies
M. Ajaimy,¹ A. Colovai,² S. Calp,¹ J. Lindower,¹ M. Melamed,³ E. Akalin.¹
¹Transplantation, Einstein/Montefiore Transplant Center, Bronx; ²Tissue Typing Laboratory, Einstein/Montefiore Transplant Center, Bronx; ³General Nephrology, Einstein/Montefiore Teaching Hospital, Bronx.
Background: We investigated the prevalence and clinical significance of C1q binding versus non-C1q binding de novo DSA in kidney transplant recipients.Methods: The study group included…
2015 American Transplant Congress
Diabetic Kidney Transplant Recipients: Impaired Infection Control and Alloreactivity
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charité Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
New onset diabetes after transplant (NODAT) has been associated with an increased risk of infection and sepsis. Previous studies, however, failed to identify differences in…
2015 American Transplant Congress
Live Donor Liver Transplantation With Older (>50years) Vs Younger (<50years) Donors: Does Age Matter?
N. Goldaracena, G. Sapisochin, J. Echeverri, M. Kaths, N. Selzner, M. Cattral, P. Greig, L. Lilly, I. McGilvray, G. Levy, A. Ghanekar, E. Renner, D. Grant, M. Selzner.
Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Introduction: The risks of living donor liver transplantation (LDLT) with older donors remains controversial and many centers avoid using live donors ≥45 years of age.…
2015 American Transplant Congress
miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight
A. Lau,^1,2 M. Vitalone,¹ X. Qu,¹ T. Shawler,¹ O. Martinez,¹ C. Esquivel,¹ S. Krams.¹
¹Surgery, Stanford University, Stanford, CA; ²Pediatrics, UCSF, San Francisco, CA.
Liver allografts are well tolerated and other solid organ allografts, when transplanted concurrently with livers, show improved outcomes. However, the mechanisms underlying “hepatic tolerance” have…
2015 American Transplant Congress
Application of Second Generation Sequencing and AlloAntibody Screening to the Organ Transplantation Arena
B. Keating,¹ Y. Li,¹ K. Olthoff,¹ J. Wang,² A. Shaked.¹
¹Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; ³Genomics, BGI, Shenzhen, China.
Over the last two decades, over 300,000 solid organ transplantations have been performed in the USA alone. While there has been considerable progress with immunosuppression…
2015 American Transplant Congress
Adverse Events of Maintenance Immunosuppression Following Kidney Transplantation Reported in Randomized Controlled Trials: A Systematic Review
M. Howell,^1,2 R. Yeo,² A. Tong,^1,2 J. Craig,^1,2 K. Howard,² G. Wong.^2,3
¹Centre for Kidney Research, The Children's Hospital at Westmead, Westmeand, NSW, Australia; ²School of Public Health, University of Sydney, Sydney, NSW, Australia; ³Centre for Transplant and Renal Research, Westmead Hospital, Westmead, NSW, Australia.
Aim: To evaluate the completeness of reporting of adverse events in randomized controlled trials (RCTs) of maintenance immunosuppression in kidney transplantation.Background: Side effects of maintenance…