Am J Transplant, Volume 5, Suppl 3 Archives - Page 22 of 170 - ATC Abstracts

2015 American Transplant Congress
Boosting the Adaptive Immune Response Prevents the High Incidence of Herpes Zoster After Lung or Heart Transplantation
N. van Besouw,¹ S. Roest,² J. Zuijderwijk,¹ R. de Kuiper,¹ J. van Weezel,³ A. van der Eijk,⁴ W. Weimar,¹ P. Hal,³ O. Manintveld.²
¹Internal Medicine - Transplantation, Erasmus MC, Rotterdam, Netherlands; ²Cardiology, Erasmus MC, Rotterdam, Netherlands; ³Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; ⁴Viroscience, Erasmus MC, Rotterdam, Netherlands.
Purpose Primary varicella zoster virus (VZV) infection causes varicella and lifelong latent infection in ganglia from which it may reactivate leading to herpes zoster (HZ).…
2015 American Transplant Congress
Can Post-Transplant C-Peptide Be Used as an Indicator of Pancreas Graft Failure?
R. Carrico,¹ J. Fridell,² J. Odorico,³ R. Stratta,⁴ K. Tyler,¹ S. Niederhaus,⁵ R. Kandaswamy,⁶ J. Fisher,⁷ O. Olaitan,⁸ M. Mujtaba.²
¹UNOS, Richmond, VA; ²Indiana Univ School of Medicine, Indianapolis, IN; ³Univ Wisconsin Hospital and Clinics, Madison, WI; ⁴Wake Forest Baptist Medical Center, Winston-Salem, NC; ⁵Univ of Maryland Medical System, Baltimore, MD; ⁶Univ of MN Medical Center, Minneapolis, MN; ⁷Scripps Green Hospital, La Jolla, CA; ⁸Rush Univ Medical Center, Chicago, IL.
Background: The OPTN Pancreas Transplantation Committee is attempting to define pancreas graft failure and performed a study to determine if C-peptide corresponds to pancreas graft…
2015 American Transplant Congress
Donor Derived Transmission Events in 2014: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)
D. Kaul,¹ S. Covington,² S. Taranto,² M. Green,¹ C. Wolfe.¹
¹OPTN Ad Hoc Disease Transmission Advisory Committee, Richmond, VA; ²United Network for Organ Sharing, Richmond, VA.
Background: The OPTN DTAC, a multidisciplinary committee, evaluates potential donor derived transmission events (PDDTE), including infections (I) & malignancies (M), to assess for donor transmitted…
2015 American Transplant Congress
Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of Graft Failure and Mortality Among Kidney Transplant Recipients
P. Clayton,^1,2,3 W. Lim,^1,4 S. Chadban.^1,2,3
¹Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, Adelaide, Australia; ²Transplantation, Royal Prince Alfred Hospital, Sydney, Australia; ³Sydney Medical School, University of Sydney, Sydney, Australia; ⁴Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Australia.
Purpose: Graft loss and death are generally late events after kidney transplantation, and trials designed to assess the impact of interventions on these outcomes are…
2015 American Transplant Congress
Effective Long-Term Prophylaxis against De Novo Hepatitis B With Hepatitis B Vaccination in Pediatric Recipients of HbcAb-Positive Liver Grafts
S. Lee, J.-M. Kim, G.-S. Choi, C.-H. Kwon, J.-W. Joh, S.-K. Lee.
Department of Surgery, Samsung Medical Center, Seoul, Korea.
Background) Controversy still exists concerning the use of livers from hepatitis B surface antigen-negative (HBsAg-)/hepatitis B core antibody-positive (HBcAb+) donors for liver transplantation (LT). We…
2015 American Transplant Congress
Left Ventricular Assist Device–Associated Allosensitization — Clinical Implications
B.-S. Ko, C. Willis, S. Drakos, D. Hurst, A. Kfoury, G. Snow, J. Delgado, E. Hammond, C. Selzman, R. Alharethi, S. McKellar, J. Nativi-Nicolau, E. Gilbert, P. Revelo, D. Miller, B. Reid, J. Fang, D. Eckles, J. Stehlik.
U.T.A.H. Cardiac Transplant Program, Salt Lake City, UT.
Purpose: Allosensitization has been recognized as a prognostic marker of worse outcome after transplant. It is unclear, however, whether sensitization events that take place shortly…
2015 American Transplant Congress
Survival Benefit of ECD Transplantation After Ultra-Long Dialysis Exposure: Implications for Acceptance in the New KAS
C. Kennedy, J. Dong, T. Myint, C. Rose, O. Johnston, J. Gill, J. Gill.
Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
The survival benefit of ECD transplantation varies with the duration of pre-transplant dialysis exposure.We analyzed the survival benefit of ECD transplantation (Kidney Donor Profile Index…
2015 American Transplant Congress
Association Between Histological Abnormalities in Time-Zero Renal Biopsies and Post-Donation eGFR in Live Donors
L. Fahmy, A. Massie, B. Orandi, S. Bagnasco, J. Alejo, B. Boyarsky, S. Anjum, R. Montgomery, N. Dagher, D. Segev.
Johns Hopkins, Baltimore.
Time-zero biopsies (T0-RBx) of live-donor kidneys may reveal histological abnormalities at the time of organ recovery. The association between T0-RBx and subsequent kidney function in…
2015 American Transplant Congress
Comparison of T Regulatory (Treg) Cell Function Pre- and Post-Lung Transplantation Shows a Major Negative Impact of Immunosuppression on Treg Function
T. Akimova,¹ J. Diamond,² D. Wilkes,³ D. Lederer,⁴ J. Christie,² W. Hancock.¹
¹Path & Lab Med, CHOP & UPenn, Philadelphia; ²Pulm, Allergy & Crit Care Med, UPenn, Philadelphia; ³Med, Microbiol & Immunol, Indiana Uni Sch of Med & Thoracic Transplant Prog, Indianapolis; ⁴Medicine, Columbia Uni, New York.
Aim: Clinical lung Tx recipients do not have sustained long-term survival outcomes comparable to that of other recipients of solid organ allografts, despite generally comparable…
2015 American Transplant Congress
Generation, Cryopreservation, Function and In Vivo Fate of Ex-Vivo Expanded Cynomolgus
H. Guo,¹ H. Zhang,¹ L. Lu,¹ M. Ezzelarab,¹ A. Thomson.^1,2
¹Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Background:Foxp3+ regulatory T cells (Treg) function to promote immune tolerance and prevent immunopathogenesis. Preclinical studies have demonstrated that adoptive transfer of Treg prevents rejection of…