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American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Kidney Transplantation After Hematopoietic Cell Transplantation in Plasma Cell Dyscrasias

    V. Domínguez-Pimentel,1 F. Fortich-Barrios,1 O. Siverio-Morales,1 E. Martín-Izquierdo,1 A. Jarque-López,1 N. Del Castillo-Rodríguez,1 J. García,1 P. Ríos,2 M. Macía.1

    1Division of Nephrology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain; 2Division of Hematology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain.

    INTRODUCTION:The plasma cell dyscrasias (PCD) include a number of entities such as multiple myeloma (MM), primary amyloidosis (AL) and Monoclonal immunoglobulin deposition disease (MIDD). Hematopoietic…
  • 2015 American Transplant Congress

    Favorable Long-Term Outcome of Late-Onset CMV Disease in D+R- Kidney Transplant Recipients Treated With Universal Prophylaxis

    H. Kaminski,1 L. Couzi,1,2 I. Garrigue,3,4 J. Déchanet-Merville,2 P. Merville.1,2

    1Nephrologie-Transplantation-Dialyse, CHU Bordeaux, Bordeaux, France; 2Unité Mixte de Recherche 5164, Centre National de la Recherche Scientifique, Bordeaux, France; 3Laboratoire de Virologie, CHU Bordeaux, Bordeaux, France; 4Unité Mixte de Recherche 5234, Centre National de la Recherche Scientifique, Bordeaux, France.

    Based on last international guidelines, both universal prophylaxis and preemptive strategies are viable approaches for the prevention of cytomegalovirus (CMV) disease after organ transplantation. Universal…
  • 2015 American Transplant Congress

    Changing Demographics of HIV+ Liver Transplant Candidates

    C. Durand, S. Gustafson, J. Locke, J. Snyder, B. Shelton, R. Reed, P. MacLennan, S. Mehta, A. Nellore, D. Segev.

    Johns Hopkins University, Baltimore, MD; Scientific Registry of Transplant Recipients (SRTR), Minneapolis Medical Research Foundation, Minneapolis, MN; University of Alabama, Birmingham, Birmingham, AL.

    Liver transplant (LT) is considered a reasonable therapeutic option for certain HIV+ patients with end-stage liver disease (ESLD). As OPTN does not collect HIV status…
  • 2015 American Transplant Congress

    HLA Broad Antigen and Eplet Mismatches in Determining the Risk of Acute Rejection After Kidney Transplantation

    H. Do Nguyen,1 W. Lim,1,2 J. Chapman,3 J. Craig,3,4 G. Wong.3,4

    1School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; 2Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; 3Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; 4School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

    Aim: To determine the clinical relevance of HLA-ABDR broad antigen and eplet matching for predicting acute rejection after kidney transplantation.Background: HLAMatchmaker determines structurally HLA compatibility…
  • 2015 American Transplant Congress

    A Novel, Blocking Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B-Cell Depletion Or Thromboembolic Events

    J. Rush,1 G. Wieczorek,1 M. Audet,2 M. Schneider,1 P. Espie,3 L. Roth,1 C. Heusser,1 C. Bruns,1 D. Patel,1 F. Cordoba.1

    1Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland; 2Hôpital de Hautepierre, Strasbourg, France; 3Drug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, Basel, Switzerland.

    Background. CD40-CD154 pathway blockade prolongs renal allograft survival in non-human primates (NHPs). However, antibodies targeting CD154 were associated with an increased incidence of thromboembolic complications…
  • 2015 American Transplant Congress

    Vaccination to Prevent the High Herpes Zoster Incidence After Renal Transplantation

    M. Kho,1 W. Weimar,1 D. Boveé,1 M. Boer-Verschragen,1 A. van der Eijk,2 N. van Besouw.1

    1Internal Medicine - Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; 2Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.

    Introduction: Herpes zoster (HZ) is the clinical manifestation of varicella zoster virus (VZV) reactivation and occurs more frequently in people with a suppressed immune system.…
  • 2015 American Transplant Congress

    Effect of Center Volume On Kidney Transplant Outcomes- Mate Kidney Analysis

    T. Klair,1 P. Friedmann,2 L. Kayler.2

    1Abdominal Organ Transplant & Hepatobiliary Surgery, Columbia University Medical Center, New York, NY; 2Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

    Background- Reports of the association of center volume and outcomes in kidney transplantation (KTX) may not provide adequate adjustment for donor risk factors. This study…
  • 2015 American Transplant Congress

    Replacement of Lamivudine By Telbivudine to Improve Renal Function for Post-Transplant Hepatitis B Patients – A Randomized Clinical Trial

    W.-C. Lee, H.-S. Chou, R.-S. Soong, T.-J. Wu, C.-H. Cheng, Y.-C. Wang, T.-H. Wu, C.-F. Lee, K.-M. Chan.

    Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan.

    Background: Lamivudine is one of the anti-hepatitis B virus (HBV) agents to prevent HBV recurrence after transplantation because lamivudine is safe for long-term use. However,…
  • 2015 American Transplant Congress

    Clinically Relevant Wound Events With Everolimus-Based Immunosuppressive Regimen: Post-Hoc Analysis from a Randomized Heart Transplant Study

    A. Zuckermann,1 M. Rinaldi,1 N. Yonan,1 S.-S. Wang,1 G. Dong,2 P. Lopez.2

    1For the A2309 Study Group, Vienna, Austria; 2Novartis, Basel, Switzerland.

    Purpose: In the A2310 (NCT00300274) heart transplant (HTx) study with everolimus (EVR) vs mycophenolate mofetil (MMF), information on a broad spectrum of potential wound healing…
  • 2015 American Transplant Congress

    DSA MFI Does Not Predict Late Antibody-Mediated Rejection Lesions Or Gene Expression Changes in Kidney Transplants

    L. Hidalgo,1 J. Venner,2 P. Halloran.2

    1Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 2Medicine, University of Alberta, Edmonton, AB, Canada.

    BACKGROUND: It is unclear whether donor-specific HLA antibody (DSA) levels at the time of a clinically-indicated biopsy can be predictive of the degree of antibody-mediated…
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