2015 American Transplant Congress
Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)
Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…2015 American Transplant Congress
Pharmacogenetic Variation in Renal Calcineurin Inhibitor (CNI) Metabolism and the Response of Allograft-Derived Proximal Tubule Cells
Background: Multiple studies have demonstrated the importance of genetic variation in CYP3A5 and ABCB1 for calcineurin inhibitor (CNI) disposition and CNI-related nephrotoxicity. Renal CNI metabolism…2015 American Transplant Congress
DNA Methylation Classifier Associates With Long-Term Graft Function Post-Kidney Transplantation
1UVA, Charlottesville, VA; 2VCU, Richmond, VA; 3Noerthwestern University, Chicago, IL.
"Background. Late graft failure is a major problem after kidney transplantation (KT) mainly due to chronic renal allograft dysfunction (CRAD). Data about common pathways of…2015 American Transplant Congress
Inhibition of mTOR Modulates SLPI Expression: A Potential Role in Kidney Transplant Patients
Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor secreted by inflammatory and epithelial cells. It functions as an endogenous immunomodulatory, with antiinflammatory and…2015 American Transplant Congress
Clinical and Biochemical Results of BK Virus Nephropathy in Kidney Allograft Recipients
BK virus (BKV) nephropathy has emerged as a significant cause of graft dysfuction in kidney allograft recipients after using powerful immunosupressive treatment protocols in recent…2015 American Transplant Congress
Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization
[Background] Preformed and newly formed alloantibody post transplantation (TX) can significantly deteriorate graft survival. Patterns of humoral rejection in sensitized patients varies significantly due to…2015 American Transplant Congress
Racial/Ethnic Differences in the Association Between Hospitalization and Kidney Transplantation Among Waitlisted End Stage Renal Disease (ESRD) Patients: A Multi-Level Mixed Modeling Approach
Background: Racial disparities in access to kidney transplantation exist among End Stage Renal Disease (ESRD) patients, even after placement on the deceased donor waitlist. One…2015 American Transplant Congress
Come Again? Part 2, Exploring Causes for Increased Rehospitalization in ECD Kidney Recipients
Surgery, Albert Einstein College of Medicine, Bronx, NY.
Previously, we demonstrated that ECD kidney recipients had an increased rate of re-hospitalization within 1 year but not 2 years post-transplant . This was a…2015 American Transplant Congress
Come Again? A Retrospective Cohort Study of Rehospitalization Following Expanded Criteria Donor Renal Transplantation
1Albert Einstein College of Medicine, Bronx, NY; 2Montefiore Medical Center, Bronx, NY.
Though ECD kidneys are commonly used, they have an increased risk of graft failure, which is associated with rehospitalizations within thirty days post-transplant. Our aim…2015 American Transplant Congress
Infectious Complications With Plasmapheresis in Combination With Antithymocyte Globulin Compared to Antithymocyte Globulin Alone in the Treatment of Acute Rejection
The Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, OH.
Background: Due to the complex nature of acute rejection (AR), multiple therapeutic modalities are necessary to prevent graft loss. The combination of prolonged cell depletion…
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