2015 American Transplant Congress
HO-1 Modified Macrophages Promote Autophagy by Activating Sirt1/TGF-β/Smad4 Signaling in Ischemia-Stressed Mouse Liver Transplants
Background: Although heme oxygenase-1 (HO-1) is known to induce alternative macrophage activation towards an anti-inflammatory M2 phenotype, the underlying mechanisms remain elusive. Autophagy may play…2015 American Transplant Congress
Hybrid Ostomy – New Technique in Intestinal Transplantation
Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.
Introduction: Many experimental non-invasive methods have been tested to assess the intestinal graft, but none of them proved to be reliable. Biopsy of the intestine…2015 American Transplant Congress
Impact of Anti-CMV Prophylactic Therapy on the Development of CMV Quantiferon Sero-Conversion in High-Risk Patients
Transplant Surgery, Medical University of South Carolina, Charleston, SC.
Body: Abdominal organ transplants at high risk for CMV infection (D+/R) remain a difficult cohort to prevent late CMV infection despite prolonged valganciclovir (VGC) administration.…2015 American Transplant Congress
The Impact of Administrating Everolimus Before Cytomegalovirus Infection to Prevent CMV Recurrence in Heart Transplant Recipients
Cardiovascular Surgery, Osaka University, Suita, Osaka, Japan.
Purpose – Cytomegalovirus (CMV) infection is a major complication in heart transplant recipients. Recent trials indicate that the use of the mammalian target of rapamycin…2015 American Transplant Congress
Variability in Incidence of Clostridium difficile Infections and Associated Mortality Among Solid Organ Transplant Recipients
Pharmacy, Tampa General Hospital, Tampa, FL.
Purpose: Solid organ transplant (SOT) recipients are at risk for Clostridium difficile infection (CDI) due to immunosuppression, frequent healthcare system contact, and liberal use of…2015 American Transplant Congress
Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation
Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…2015 American Transplant Congress
Mesenchymal Stromal Cells (MSCs) Given Post-Transplant Together With C3a and C5a Receptor Antagonists Prevent Engraftment Syndrome and Induce a Mild Not-Significant Prolongation of Graft Survival
Bone marrow (BM)-derived MSC given the day before kidney allografts localize into lymphoid organs and induce significant prolongation of graft survival in mice. By contrast,…2015 American Transplant Congress
Lipid Profiles Over 2 Years Follow-Up in De Novo Kidney Transplant Recipients Randomized to Once-Daily MeltDose® Tacrolimus (Envarsus® XR) Vs. Twice-Daily Tacrolimus (Prograf®): Results from a Phase 3, Double-Blind, Double-Dummy, Multicenter Trial
Cardiovascular disease (CVD) is a leading cause of death in kidney transplant recipients (KTR). Focusing on modifiable CVD risk factors is key to decreasing CVD-related…2015 American Transplant Congress
In Pre-Implantation Biopsies Expression of Micro RNAs Is Not a Good Surrogate for Established mRNA Markers of Kidney Injury
1University of Alberta, Edmonton, Canada; 2University of Marlyland, Baltimore.
Kidneys from brain dead donors>50 years old are often discarded based on conventional (clinical and histologic) criteria, despite their poor predictive value for subsequent performance…2015 American Transplant Congress
Increased Late Graft Loss in Kidney Recipients With Serum Sickness Disease Following Anti-Thymocyte Globulin Induction: Relation With an Anti-Neu5Gc Response
Anti-thymocyte globulins (ATG) are rabbit IgGs against human T cells widely used as induction treatment of kidney recipients. ATG can induce immune-complex diseases including Serum…
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