Am J Transplant, Volume 5, Suppl 3 Archives - Page 168 of 170 - ATC Abstracts

2015 American Transplant Congress
Distinct Clinical Relevance of BAFF Expression Within the Kidney Graft and Soluble BAFF Serum Levels Indicate Confined Alloimmune Responses Disconnected from the Periphery
E. Campos,^1,2 K. Mine,¹ A. Goncalves-Primo,^1,2 M. Soares,⁴ M. Franco,² J. Medina-Pestana,^2,3 H. Tedesco-Silva,³ M. Gerbase-DeLima.^1,2
¹Instituto de Imunogenética, AFIP, São Paulo, SP, Brazil; ²Universidade Federal de São Paulo, São Paulo, SP, Brazil; ³Hospital do Rim e Hipertensão- FOR, São Paulo, SP, Brazil; ⁴Universidade Federal do Parana, Curitiba, PR, Brazil.
As soluble B-cell activating factor (BAFF) serum levels (sBAFF) may not reflect BAFF concentrations within the graft, what could be related to the inconsistencies in…
2015 American Transplant Congress
Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection
H. Zhang,¹ D. Thomas,¹ J. Kowalewska,² E. Suviolahti,¹ H. Shafi,² C. Nast,² A. Gertych,² A. Vo,¹ M. Haas,² S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: IL-6 exerts immunoregulatory properties through IL-6 receptors, IL-6Rα and gp130. Our previous studies suggested the involvement of antibody-dependent cellular cytotoxicity (ADCC) and its related…
2015 American Transplant Congress
Biopsychronology: Live Confocal Imaging of Biopsies to Assess Organ Function
M. Ashraf,¹ D. Fries,² W. Streif,³ F. Aigner,¹ P. Hengster,¹ J. Troppmair,¹ M. Hermann.²
¹VTT, DSL, Innsbruck Medical University, Innsbbruck, Austria; ²Anestesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria; ³Pediatrics I, Innsbruck Medical University, Innsbruck, Austria.
Methods to monitor the status of a graft prior to transplantation are highly desirable to avoid unnecessary clinical interventions and to optimize the clinical outcome…
2015 American Transplant Congress
Endosome-Based Activation of Non-Canonical NF-kB Signaling By Membrane Attack Complexes
D. Jane-wit,¹ Y. Surovtseva,² L. Qin,³ P. Clark,⁴ T. Manes,⁴ M. Kashgarian,⁵ N. Kirkiles-Smith,⁴ R. Liu,⁴ C. Wang,⁴ G. Tellides,³ J. Pober.⁴
¹Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT; ²Yale Center for Molecular Discovery, Yale University School of Medicine, New Haven, CT; ³Department of Surgery, Yale University School of Medicine, New Haven, CT; ⁴Department of Immunobiology, Yale University School of Medicine, New Haven, CT; ⁵Department of Pathology, Yale University School of Medicine, New Haven, CT.
Using sera from transplant patients with high-titer panel reactive antibody (PRA), we previously described a model for studying the effects of alloantibody binding and complement…
2015 American Transplant Congress
Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
2015 American Transplant Congress
The Onset of Post-Transplant Malignancies Is Related to a Change in Gene Expression Profiles in Peripheral Blood Mononuclear Cells
G. Stallone,¹ R. Federica,¹ P. Pontrelli,² M. Accetturo,² A. Oranger,² M. Gigante,² G. Castellano,² A. Schena,² M. Fiorentino,² B. Infante,¹ L. Gesualdo,² G. Grandaliano.¹
¹Dept.of Surgical and Medical Sciences, Nephrology Unit, University of Foggia, Foggia, Italy; ²Dept. of Emergency and Organ Transplantation, Nephrology Unit, University of Bari, Bari, Italy.
Malignancies are the third leading cause of death in renal transplant recipients and their incidence is increasing. Although the role of the immune system in…
2015 American Transplant Congress
Pregnancy Outcomes in Solid Organ Transplant Recipients With Exposure to Sirolimus Without Mycophenolate
N. Sifontis,¹ L. Coscia,² D. Armenti,² S. Constantinescu,^2,3 M. Moritz.^2,4
¹Pharmacy Practice, Temple University, Philadelphia; ²National Transplantation Pregnancy Registry, Gift of Life Institute, Philadelphia; ³Temple University School of Medicine, Philadelphia; ⁴Lehigh Valley Health Network, Allentown.
Results of prior sirolimus series reports have been confounded by concomitant mycophenolate exposure. The purpose of this study was to describe pregnancy outcomes with exposure…
2015 American Transplant Congress
Single Center Experience of C4d Staining of Kidney Transplant Biopsies
R. Prashar, L. Yessayan, M. Goggins, V. Karthikeyan, K. Venkat, A. Patel.
Division of Nephrology and Transplant Institute, Henry Ford Hospital, Detroit, MI.
Introduction: While a diffuse positivity (>50%) of C4d in kidney transplant peritubular capillaries strongly co-relates with the presence of acute or chronic antibody mediated rejection,…
2015 American Transplant Congress
Macrophage-Specific SIRT1 Regulates HO-1 Mediated Anti-Inflammatory and Cytoprotective Pathways
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, is essential for resistance against liver ischemia-reperfusion injury (IRI). We asked whether SIRT1 may affect cytoprotective…
2015 American Transplant Congress
Antithymocyte Globulin-Induced Platelet Hypercoagulability Is a Consequence of Complement Activation and Microvesicle Release
D. Zecher,^1,4 A. Cumpelik,¹ D. Tsakiris,² M. Dickenmann,³ J. Schifferli.¹
¹Department of Research, Basel University Hospital, Basel, Switzerland; ²Department of Hematology, Basel University Hospital, Basel, Switzerland; ³Department of Nephrology, Basel University Hospital, Basel, Switzerland; ⁴Department of Nephrology, Regensburg University Hospital, Regensburg, Germany.
T cell depletion with antithymocyte globulins (ATG) can be complicated by thrombopenia andhypercoagulability. The underlying mechanism is still unclear. We found that binding of ATG…