Am J Transplant, Volume 5, Suppl 3 Archives - Page 165 of 170 - ATC Abstracts

2015 American Transplant Congress
Utilization and Characteristics of Pancreas and Simultaneous Kidney-Pancreas Donors in the US by OPTN-Defined Increased Risk Donor Status
M. Ison,^1,2 B. Ho,² J. Leventhal,² D. Ladner.²
¹Infectious Diseases, Northwestern University, Chicago; ²Organ Transplantation, Northwestern University, Chicago.
Background: The number of candidates in need of pancreas transplantation is far larger than the number of organ donors. To expand the organ pool, there…
2015 American Transplant Congress
Heart En Bloc Thymus Transplantation Permits Long-Term, Acute Rejection-Free Cardiac Allograft Survival in Nonhuman Primates (NHPs)
M. Tonsho,¹ P. Spencer,¹ T. Millington,¹ A. Muniappan,¹ A. Tena,² R. Smith,³ R. Colvin,³ J. Allan,^1,2 J. Madsen.^1,2,4
¹MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ³Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
BACKGROUNDThe role of vascularized thymus on tolerance induction has been well studied in swine recipients of kidney allografts, but not in NHP recipients of heart…
2015 American Transplant Congress
Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus
P. Chhabra,¹ A. Spano,² D. Bowers,¹ M. Wu,² L. Langman,¹ M. Timko,² K. Brayman.¹
¹Department of Surgery, University of Virginia, Charlottesville, VA; ²Department of Biology, University of Virginia, Charlottesville, VA.
Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…
2015 American Transplant Congress
The Effect of Compatibility of ABO Blood Type Antigens on Graft Survival of Intestinal Transplants
J. Cai,¹ A. Qing,² G. Wu,³ M. Everly,¹ P. Terasaki.¹
¹Terasaki Foundation Lab, Los Angeles; ²Lincoln High School, Stockton; ³The 4th Military Medical University, Xi-An, China.
Due to the introduction of new immunosuppressive agents and development of pre- and post-transplant patient management, ABO blood group incompatibility is no longer considered an…
2015 American Transplant Congress
Determinants of Accelerated CAV in Heart Allografts: Major Independent Impact of Circulating DSA
M. Bories, Varnous, Guillemain, Suberbielle, Jouven, Bruneval, Duong, Loupy.
Paris Translational Research Center for organ Transplantation, Paris, France.
BackgroundChronic allograft vasculopathy (CAV) is the leading cause of late failing heart allografts and is associated with mortality. The determinants of CAV integrating traditional cardiovascular…
2015 American Transplant Congress
Late Recurrent UTIs in Kidney Transplant Patients: Risk Factors , Microbiologic and Antibiotic Resistance Patterns
A. Regmi, D. Kumar, A. King, G. Gupta.
Division of Nephrology, Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA.
Background: Urinary tract infections (UTI) are the most common infection among kidney transplant (KT) patients and are associated with significant morbidity and mortality. Most studies…
2015 American Transplant Congress
Effectiveness of Neovascularization Surrounding Engrafted Islets by Matrigel With Additional Growth Factors in Intramuscular Islet Transplantation
G. Yoshimatsu,^1,2 N. Sakata,² H. Tsuchiya,² M. Takita,³ M. Levy,³ B. Naziruddin,³ M. Unno.²
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
Introduction: Intramuscular islet transplantation is one of the promising transplant sites because of safety, easy accessibility and less invasive procedure. However the efficacy of the…
2015 American Transplant Congress
Induction of iNOS Expressed Macrophages from Mouse iPS cells That Contribute to Prolong Same iPS Cells-Derived Graft Survival in Allogeneic Recipients
H. Sasaki,¹ H. Wada,² K. Morita,¹ K.-I. Seino,² N. Shinohara.¹
¹Genitourinary Surgery, Hokkaido University, Sapporo, Japan; ²Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
BACKGROUND: Induced pluripotent stem cells (iPSCs)-technology provides new opportunities in regenerative medicine to generate grafts from donors for transplantation. However, particularly when allogeneic iPSCs are…
2015 American Transplant Congress
Improved Bioavailability and Reduced Dose Requirements of Novel, Once-Daily, MeltDose® Tacrolimus Formulation Tablets (Envarsus® XR) Compared to Twice-Daily Tacrolimus Capsules (Prograf®) in De Novo Kidney Transplantation: Results of a Phase 3 Double-Dummy, Randomized Trial
J. Grinyó,¹ S. Bunnapradist,² S. Mulgaonkar,³ S. Steinberg.⁴
¹University of Barcelona, Catalunya, Barcelona, Spain; ²David Geffen School of Medicine at UCLA, Los Angeles; ³St. Barnabas Medical Center, Livingston; ⁴California Institute of Renal Research, San Diego.
Tacrolimus (tac) is an immunosuppressive drug with a narrow therapeutic range. Adequate trough levels following kidney transplantation (≥6 ng/mL depending on regimen and time post-transplant)…
2015 American Transplant Congress
Increase in Neurologic Determination of Death (NDD) Organ Donation in the Donation After Circulatory Death (DCD) Era. The Ontario Experience
J. Zaltzman,^1,2 J. MacLean,² C. Payne,² E. Paltser,² V. Rao,³ S. Dhanani.^2,4
¹Medicine, Nephrology & Transplant, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; ²Trillium Gift of Life Network, Ontario, Toronto, ON, Canada; ³Cardiovascular Surgery and Multi-Organ Transplant, University Health Network, University of Toronto, Toronto, ON, Canada; ⁴Pediatric Critical Care, Children's Hospital of Eastern Ontario, Univeristy of Ottawa, Ottawa, ON, Canada.
Some jurisdictions have reported a decrease in neurologic determination of death organ donors (NDD) with the implementation of donation after circulatory death (DCD) organ donation.…