Am J Transplant, Volume 5, Suppl 3 Archives - Page 165 of 170 - ATC Abstracts

2015 American Transplant Congress
Anti-CD122 + Costimulation Blockade Prolongs Allograft Survival
D. Mathews,¹ L. Higginbotham,¹ Y. Dong,¹ C. Breeden,¹ C. Larsen,¹ J. Tso,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²JN Bioscience, Mountanview, CA.
Introduction: Effective T cell activation and effector function requires (1) cognate antigen recognition (2) appropriate costimulation and (3) successful cytokine signaling. Recently approved strategies to…
2015 American Transplant Congress
Feasibility of Regulatory T Cell Cryopreservation and Banking for Clinical Therapeutic Applications
K. Gołąb,¹ O. Savari,¹ S. Ramachandran,¹ Z. Tekin,¹ M. Tibudan,¹ J. Millis,¹ P. Trzonkowski,² P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Immunology, Medical University of Gdansk, Gdansk, Poland.
Feasibility of clinical application of regulatory T cells (Tregs) in clinical transplantation would be improved if Tregs or pre-enriched cells for Treg isolation could be…
2015 American Transplant Congress
Pre-Operative Assessment of Body Composition in Adult Multivisceral Transplant Candidates
R. Cruz, H. Sogawa, G. Bond, K. Soltys, R. Sindhi, G. Mazariegos, A. Humar, A. DiMartini.
Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Body Mass Index is commonly used, but is likely to be an inexact measurement of nutritional status. For this reason, we examined whether body composition…
2015 American Transplant Congress
Clinical Outcome of Patients With De Novo C1q Binding Donor-Specific HLA Antibodies After Renal Transplantation
J. Bamoulid,¹ A. Roodenburg,² O. Staeck,¹ C. Schoenemann,² N. Lachmann,² K. Budde.¹
¹Nephrology, Charite Hospital-University of Medicine, Berlin, Germany; ²HLA Laboratory, Charite Hospital-University of Medicine, Berlin, Germany.
A. Not all de novo donor-specific HLA antibodies (dnDSA) are causing immediate graft loss. The importance of complement-binding DSA was recently shown with a commercial…
2015 American Transplant Congress
Age-Specific Graft Failure Rates in Pediatric Heart Transplant Recipients
B. Foster,¹ M. Dahhou,¹ X. Zhang,¹ V. Dharnidharka,² V. Ng,³ J. Conway.⁴
¹Pediatrics, Research Institute of the McGill Univ. Health Centre, Montreal, QC, Canada; ²Pediatrics, Washington Univ., St. Louis, MO; ³Pediatrics, Hospital for Sick Children, Toronto, ON, Canada; ⁴Pediatrics, Stollery Children's Hospital, Edmonton, AB, Canada.
Graft failure risk has been shown to peak during emerging adulthood (18-25 y) among kidney transplant recipients. The association between age and graft failure risk…
2015 American Transplant Congress
Improving Latent Tuberculosis Diagnosis Before Kidney Transplantation in a Developing Country
G. Meinerz,^1,2 C. da Silva,^1,2 E. Keitel,^1,2 A. Pasqualotto,³ J. Goldani,^1,2 C. Zeni,^1,4 F. Vacilotto,^1,4 N. Prado,^1,4 A. Monteiro,^2,3 D. Seelig,¹ F. Klaus,¹ J. Andrade,¹ V. Garcia.¹
¹Nephrology and Kidney Transplantation, Irmandade Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegre, Rio Grande do Sul, Brazil; ²Programa de Pós-Graduação em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil; ³Laboratorio de Biologia Molecular, Irmandade Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegre, Rio Grande do Sul, Brazil; ⁴Programa de Residência em Nefrologia, Universidade Federal de Ciencias da Saude de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil.
Introduction: Tuberculosis has shown to be a great challenge in kidney transplantation, specially in developing countries due to the difficulties in diagnosis and treatment, leading…
2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Human Gingival Tissue-Derived Mesenchymal Stem Cells Reduce Murine Acute GVHD Via Killing of Effector CD8+ Cells Through CD39/Adenosine A1R and A2BR Pathways
J. Gu, L. Ling.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Human gingival tissue-derived mesenchymal stem cells (GMSCs) are a convenient source of MSCs that have been shown to treat autoimmune disease. Here we use human…
2015 American Transplant Congress
Comparison of Pharmacokinetics and Pharmacogenomics of Once-Daily Extended-Release MeltDose® Tacrolimus Tablets (Envarsus® XR) Vs. Twice-Daily Tacrolimus Capsules in Stable African American Kidney Transplant Patients: A Randomized Cross-Over Study
J. Trofe-Clark,^1,2 D. Brennan,³ P. West-Thielke,⁴ M. Milone,⁵ M. Lim,² R. Bloom.²
¹Pharmacy Services, Hospital of the University of Pennsylvania, Philadelphia; ²Renal Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia; ³Renal Division, Washington University, St. Louis; ⁴University of Illinois at Chicago, Chicago; ⁵Penn Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
The CYP3A5 genotype is the most significant genetic factor impacting tacrolimus (tac) metabolism; expresser's of this genotype require higher tac doses to achieve therapeutic tac…
2015 American Transplant Congress
Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits
Z. Zhong,¹ Z. Liu,¹ R. Wang,¹ Z. Fu,² Y. Zhang,² Q. Hu,¹ K. Jin,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…