ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Pancreas-Derived Mesenchymal Stem Cells from Chronic Pancreatitis Patients Enhance Islet Graft Function

    M. Lawrence,1 F. Kunnathodi,1 N. Borenstein-Auerbach,1 G. Yoshimatsu,1 M. Kanak,2 R. Shahbazov,1 M. Takita,1 M. Levy,3 B. Naziruddin.3

    1Baylor Research Institute, Dallas, TX; 2Baylor University, Waco, TX; 3Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.

    PURPOSE: Islet transplantation represents a promising procedure to reverse or prevent diabetes. However, significant mass of islet graft is lost within hours of transplantation due…
  • 2015 American Transplant Congress

    Effect of Everolimus on Left Ventricular Hypertrophy in De Novo Kidney Transplant Recipients: 12-Month Results from the ELEVATE Study

    M. van der Giet,1 H. Holdaas,1 J. de Fijter,1 A. Speziale,2 C. Escrig,2 G. Junge,2 Z. Wang,3 J. Cruzado.1

    1For the ELEVATE Study, Berlin, Germany; 2Novartis, Basel, Switzerland; 3Novartis Corporation, East Hannover, NJ.

    Background: Left ventricular hypertrophy (LVH) is common in kidney transplant recipients (KTxR) and has shown to be a risk factor for death and heart failure…
  • 2015 American Transplant Congress

    Outcomes Between ABO-Incompatible Living Donor Liver Transplantation (LDLT) and ABO-Compatible LDLT: A Matched Study

    J. Kim, S. Lee, W. Cho, J.-Y. Choi, G.-S. Choi, J. Park, C. Kwon, S. Kim, J.-W. Joh, S.-K. Lee.

    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

    Backgrounds: Reports from several experienced centers suggested that outcomes of an ABO-incompatible (ABOi) living donor liver transplantation (LDLT) after rituximab and reduction of ABO antibodies…
  • 2015 American Transplant Congress

    Reciprocal Relationship Between Cytomegalovirus Infection and Graft Rejection in Intestinal/Multivisceral Transplantation: Impact on Survival and Ideal Immunosuppression Protocol

    S. Nagai, R. Mangus, E. Anderson, K. Doan, B. Ekser, C. Kubal, J. Fridell, A. Tector.

    Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN.

    Background: Cytomegalovius (CMV) infection and graft rejection are opposing complications of isolated intestinal/multivisceral transplantation (IIT/MVT), a procedure requiring precise balance of immunosuppression. The aim of…
  • 2015 American Transplant Congress

    Impact of Donor and Recipient BKV Serostatus and the Effect of Ciprofloxacin Prophylaxis on BK Viremia Risk After Kidney Transplant

    M. Changala,1 A. Kistler,2 J. Abend,2 A. Sathe,2 A. Howard,1 D. Wojciechowski.1

    1University of California, San Francisco, San Francisco, CA; 2Novartis Institutes for Biomedical Research, Emeryville, CA.

    Background: BK virus (BKV) is a common infection in kidney transplant recipients. Due to widespread latent BKV infection in the general population, it is possible…
  • 2015 American Transplant Congress

    Immunologic Outcomes in Elderly Kidney Transplant Recipients

    D. Khadzhynov, F. Halleck, L. Liefeldt, P. Glander, J. Bamoulid, S. Kreimer, L. Lehner, K. Budde, O. Staeck.

    Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.

    BACKGROUND: Only few data are available about immunologic outcomes of elderly kidney transplant recipients (KTR).PATIENTS AND METHODS: This retrospective long-term observational study included all adult…
  • 2015 American Transplant Congress

    Financial Burden of Laparoscopic Living Kidney Donation

    J. Wiseman, D. Larson, D. Berglund, C. Jacobs, C. Garvey, H. Ibrahim, A. Matas.

    U of MN, Mpls.

    Living kidney donation rates are declining; one cause may be the extent of the unreimbursed expenses associated with donation. We studied financial burden in a…
  • 2015 American Transplant Congress

    Effects of Toll Like Receptor (TLR) Signaling on Murine Alloimmunity Are Modulated by Immune Cell Derived Complement

    J. Sheen, P. Heeger.

    Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

    TLR signals prevent CD40L-blockade (MR1) induced murine transplant tolerance but mechanisms are incompletely understood. Based on previous findings that immune cell derived complement activation products…
  • 2015 American Transplant Congress

    Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival

    J. Kwun, C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, S. Knechtle.

    Surgery, Emory Transplant Center, Atlanta, GA.

    [Background] Preformed donor specific antibody (DSA) due to prior sensitization affects a significant population of transplant patients, portending a poorer prognosis in short- and long-term…
  • 2015 American Transplant Congress

    Normothemic Machine Perfusion of Liver Grafts Promotes Liver Regeneration and Inhibits Tissue Inflammation

    E. Xystrakis, J. Lozano, R. Danger, M. Martinez-Llordella, P. Srinivasan, N. Heaton, C. Coussios, A. Sanchez-Fueyo, Y. Ma, W. Jassem.

    Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, London, United Kingdom; Plataforma de Bioinformatica, Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clinic, Centre Esther Koplovitz (CEK), Barcelona, Spain; Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom.

    Background & aim: liver transplantation I/R injury is associated with inflammation, affecting graft outcome. Ex-vivo normothermic machine perfusion (NMP) to donor livers before transplantation reduces…
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