Am J Transplant, Volume 5, Suppl 3 Archives - Page 161 of 170 - ATC Abstracts

2015 American Transplant Congress
B7-H1 Deficiency in Liver Allografts Leads to CD8-Mediated Acute Vascular Rejection
M. Morita, D. Joyce, J. Fung, S. Qian, R. Fairchild, L. Lu.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Clevland Clinic, Cleveland, OH.
The liver is a unique organ in that it is accepted across complete MHC mismatch in allotransplantation in a number of species. The mechanisms behind…
2015 American Transplant Congress
Investigation of Myocardial Function in Pediatric Transplant Recipients
K. Sgambat, S. Clauss, M. Lasota, A. Moudgil.
Children's National, Washington, DC.
Purpose: In light of the major impact of cardiovascular morbidity on long-term transplant outcomes, a prospective controlled study was conducted to investigate changes in myocardial…
2015 American Transplant Congress
Adoptive Transfer of T Cell Receptor-Transgenic (TCR-Tg) Cells Alters Endogenous Immune Responses During Acute Rejection
M. Miller, M. Daniels, Y. Wang, D. Yin, A. Chong, M.-L. Alegre.
University of Chicago, Chicago, IL.
In addition to the therapeutic use of adoptive transfer of T cells to combat viral infections and malignancies in humans, adoptive transfer of T cell…
2015 American Transplant Congress
Immunoglobulin G Donor-Specific Anti-HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury
D. Viglietti,^1,2 C. Bentlejewski,³ J.-P. Duong van Huyen,^4,2 D. Vernerey,^5,2 O. Aubert,² J. Verine,¹ X. Jouven,² C. Legendre,⁴ D. Glotz,¹ A. Loupy,^2,4 A. Zeevi,³ C. Lefaucheur.^1,2
¹Saint-Louis Hospital, Paris, France; ²Paris Translational Research Center for Organ Transplantation - INSERM U970, Paris, France; ³University of Pittsburgh Medical Center, Pittsburgh; ⁴Necker Hospital, Paris, France; ⁵CHRU de Besançon, Besançon, France.
Experimental and clinical data suggest that antibodies have different pathogenicities according to their IgG subclasses. We investigated the association between IgG subclasses of circulating anti-HLA…
2015 American Transplant Congress
Outcomes Associated With Carbapenem-Resistant Klebsiella Pneumoniae (CRKP) in Solid Organ Transplant (SOT) Recipients
T. Bias,¹ A. Sharma,² G. Malat,³ D. Lee,² A. Doyle.²
¹Dept of Pharmacy, Hahnemann University Hospital, Philadelphia; ²Dept of Medicine, Drexel University, College of Medicine, Philadelphia; ³Dept of Surgery, Drexel University, College of Medicine, Philadelphia, PA.
Background: Infection with CRKP is emerging as an important challenge among SOT recipients. Our study aims to describe the epidemiology and clinical outcomes associated with…
2015 American Transplant Congress
Extended Analysis of Tocilizumab (anti-IL-6R) + Intravenous Immunoglobulin (IVIG) as Desensitization (DES) Agents for Reduction of Donor Specific Antibodies (DSA) in Patients Resistant to DES With IVIG + Rituximab
A. Vo, J. Choi, I. Kim, J. Kahwaji, A. Peng, R. Villicana, S. Jordan.
Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: IVIG+rituximab is an acceptable approach for DES with good outcomes. Despite this, ∼30% of patients fail DES, thus other approaches are needed. Options include…
2015 American Transplant Congress
Monitoring Intracellular Tacrolimus Concentration in Kidney Transplant Recipients With Stable Graft Function
E. Bae,¹ S. Han,¹ S. Yang,² J. Park,¹ H. Lee,¹ J. Lee,³ D. Kim,¹ Y. Kim.¹
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Kidney Research Institute, Seoul National University, Seoul, Korea; ³Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Background: Monitoring the intracellular concentration of immunosuppressive agents can be promising to improve and individualize clinical practice in patients receiving transplantation. However, this issue remains…
2015 American Transplant Congress
Outcomes of HIV+ Liver Transplant Recipients Compared to HCV+ or HIV+/HCV+ Co-Infected Recipients: The “Real World” Experience
D. Sawinski,¹ G. David,² E. Blumberg,³ P. Abt,⁴ R. Bloom,¹ K. Forde.²
¹Renal Division, Univ. of Penn, Philadelphia, PA; ²Gastroenterology Division, Univ. of Penn, Philadelphia, PA; ³Infectious Disease, Univ. of Penn, Philadelphia, PA; ⁴Surgery, Univ of Penn, Philadelphia, PA.
End stage liver disease is a frequent cause of mortality in patients with HIV. Though demonstrated in the NIH observational trial, the effectiveness of LT…
2015 American Transplant Congress
Identifying the “Operational Tolerant” Pediatric Liver Transplant Recipient by Cytometry by Time-of-Flight
A. Lau,^1,2 M. Vitalone,¹ K. Haas,³ T. Shawler,¹ C. Esquivel,¹ O. Martinez,¹ R. Castillo,³ S. Krams.¹
¹Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; ²Pediatrics, Div. Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, San Francisco, CA; ³Pediatrics, Div. Gastroenterology, Hepatology, and Nutrition, Stanford University, Stanford, CA.
Liver allografts are known to be well tolerated and indeed, some recipients of liver allografts retain stable graft function in the absence of immunosuppression. The…
2015 American Transplant Congress
Role of Innate Immune Cells in Chronic Allograft Loss and Novel Strategies to Target Them
C. Wu,^1,2 P. Zhao,¹ W. Liu,¹ X. Xiao,¹ X. Shi,¹ Y. Peng,¹ M. Kloc,¹ X. He,² M. Ghobrial,¹ X. Li.¹
¹Center for Immunobiology and Transplantation Research, Houston Methodist Hospital and Houston Methodist Research Institute, Houston, TX; ²Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Despite remarkable improvements in short term transplant survival, the long-term outcome of allografts remains poor in the clinic, and most transplants are eventually lost due…