ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    The Role of an Intragraft Vascularized Bone Marrow Niche in Establishing Mixed Chimerism and Allograft Acceptance

    M. Fryer, B. Oh, G. Furtmüller, G. Raimondi, G. Brandacher.

    Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.

    Background: Vascularized composite allotransplantation has emerged as a viable treatment option for patients with devastating tissue loss not amenable to traditional reconstructive techniques. Different from…
  • 2015 American Transplant Congress

    Infusion of Human Factor 7a Restores Circulating Platelets and Prevents TMA in Pig-to-Baboon Liver Xenotransplantation

    J. Shah, N. Navarro-Alvarez, H. Yeh, N. Elias, J. Ligocka, J. Markmann, M. Hertl, D. Sachs, P. Vagefi.

    Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA.

    Background We sought to determine the effects of exogenous administration of human coagulation factors in a pig-to-baboon model of liver xenotransplantation (LXT).Methods LXT was performed…
  • 2015 American Transplant Congress

    The Immunogenic Perlecan Fragment LG3 Is Released Through Apoptotic Extracellular Vesicles Downstream of Caspase-3 Activation

    D. Beillevaire,1 J. Turgeon,1 D. Gingras,2 é. Boilard,3 M. Dieudé,1 M.-J. Hébert.1

    1CNTRP, CRCHUM, Université de Montréal, Montréal, Canada; 2Université de Montréal, Montréal, Canada; 3CNTRP, CHUL, Québec, Canada.

    LG3, a C-terminal fragment of perlecan, has been implicated in aggravation of renal allograft rejection and vascular injury. LG3 is known to be produced at…
  • 2015 American Transplant Congress

    Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization

    N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    [bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…
  • 2015 American Transplant Congress

    Racial Disparities in Preemptive Kidney Transplant Referrals in Georgia: Data from the RaDIANT Community Study

    J. Gander,1 L. Plantinga,1 M. Basu,1 L. Sauls,2 S. Pastan,1 E. Gibney,3 L. Mulloy,4 R. Patzer.1

    1Emory University, Atlanta; 2Southeastern Kidney Council, Raleigh; 3Piedmont Hospital, Atlanta, GA; 4Georgia Regents University, Augusta, GA.

    PurposeAccess to kidney transplantation (KTx) before initiation of dialysis is associated with improved patient and graft survival, enhanced quality of life, and decreased hospital readmissions…
  • 2015 American Transplant Congress

    National Outcomes of Kidney Transplantation from Diabetic Donors

    J. Cohen,1 P. Reese,1 P. Porrett,2 R. Bloom,1 K. Forde,3 D. Sawinski.1

    1Renal Division, Univ. of Penn, Philadelphia, PA; 2Dept of Surgery, Univ. of Penn, Philadelphia, PA; 3Division of Gastroenterology, Univ. of Penn, Philadelphia, PA.

    Despite limited outcomes data, kidneys from diabetic donors are being increasingly used in the USA. To compare outcomes in recipients of kidneys from diabetic versus…
  • 2015 American Transplant Congress

    Impact of Type of Tacrolimus Assay on Therapeutic Drug Monitoring: Need for Standardization

    M. Singh, S. Anwar, D. Brennan, R. Delos Santos.

    Internal Medicine/Nephrology, Washington University School of Medicine, St. Louis, MO.

    Background: Multiple assays are available for measuring tacrolimus (FK) levels and these are not currently standardized. A designated laboratory transitioned their FK assay from Enzyme…
  • 2015 American Transplant Congress

    Return to Work and Occupational Infection Risks in Transplant Recipients

    R. Avery,1 D. Ostrander,1 S. Shoham,1 S. Alp,2 N. Lu,1 C. Cave,1 E. Kraus,3 K. Marr.1

    1Infectious Disease, Johns Hopkins, Baltimore, MD; 2Infectious Diseases and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey; 3Nephrology, Johns Hopkins, Baltimore, MD.

    Background: Counseling is commonly provided to transplant recipients who are planning to return to work, regarding potential infection risks in the workplace. However, the nature…
  • 2015 American Transplant Congress

    Pre-Transplant Desensitization Protocol and Cancer Risk in Kidney Transplantation

    I. Revuelta,1,2,3 R. Ferreira,1 C. Canha,1 P. Piselli,4 D. Verdirosi,4 V. Tubita,2 E. De Sousa,1 F. Diekmann,1,2,3 M. Lozano,2,5 J. Cid,5 E. Palou,6 J. Martorell,6 A. Alcaraz,7 D. Serraino,8 F. Oppenheimer,1,2,3 J. Campistol.1,2,3

    1Renal Transplant Unit, Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain; 2IDIBAPS, Barcelona, Spain; 3REDinREN. Carlos III Royal Institute. Ministry of Health, Madrid, Spain; 4Dipartamento di Epidemiologia e Ricerca Pre-Clinica, INMI “L. Spallanzani” IRCCC, Rome, Italy; 5Hemotherapy and Hemostasis, Hospital Clinic, Barcelona, Spain; 6Department of Immunology, Hospital Clinic, Barcelona, Spain; 7Department of Urology, Hospital Clinic, Barcelona, Spain; 8IRCCS Centro di Riferimento Oncologico, Aviano, Italy.

    Introduction: Desensitization (DS) in kidney transplant is a current therapy for all cause of incompatible living donor kidney transplants (LDKT). The impact in cancer risk…
  • 2015 American Transplant Congress

    The Impact of Ischemia/Reperfusion Injury On Liver Allografts from Deceased After Cardiac Death Versus Deceased After Brain Death Donors

    B. Sayed, J. Xu, A. Casas-Ferreira, P. Srinivasan, N. Heaton, Y. Ma, C. Legido-Quigley, S. Fuggle, W. Jassem.

    1Liver Transplant Unit, Institute of Liver Studies, King's College Hospital, London, United Kingdom; Department of Transplant Surgery, Emory University, Atlanta, United Kingdom; Institute of Pharmaceutical Science, King's College Hospital, London, United Kingdom; Department of Analytical Chemistry, University of Salamanca, Salamanca, Spain; Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom.

    Background and Aims:The shortage of appropriate organs for transplantation has led to the use of organs from donors after cardiac death. The pathophysiologic processes associated…
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