Am J Transplant, Volume 5, Suppl 3 Archives - Page 160 of 170 - ATC Abstracts

2015 American Transplant Congress
Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function
A. Gilbert,¹ E. Hall,¹ O. Timofeeva,² M. Awwad,² M. Grafals,¹ P. Weems,¹ D. Li,² S. Rosen-Bronson,² J. Moore,¹ B. Javaid,¹ M. Cooper.¹
¹Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; ²Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.
Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
2015 American Transplant Congress
Discard of Kidneys at the Margin: ECD Versus KDPI Era
S. Bae, A. Massie, D. Segev.
Johns Hopkins, Baltimore, MD.
BACKGROUND: Since 3/26/2012, the Kidney Donor Profile Index (KDPI), a percentile score reflecting donor-associated risk, has been provided with all deceased-donor kidney offers. We investigated…
2015 American Transplant Congress
New SRTR Risk-Adjustment Models for Adult Kidney Transplant Outcomes
J. Snyder,¹ N. Salkowski,¹ D. Zaun,¹ H. Xiong,¹ S. Leppke,¹ B. Thompson,¹ D. Segev,^1,2 L. Hunsicker,¹ A. Israni,¹ B. Kasiske.¹
¹Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; ²Johns Hopkins University, Baltimore, MD.
Following a recommendation of the Consensus Conference on Transplant Program Quality and Surveillance, SRTR implemented a 3-year rolling cycle to rebuild the statistical models used…
2015 American Transplant Congress
Toll-Like Receptor 4-Signaling Abrogates Inhibitory Effect of Calcineurin Inhibitor on B-Cells Responding to Blood Group A-Antigens
H. Sakai, Y. Tanaka, H. Ohdan.
Transplant Unit, Hiroshima University, Hiroshima, Japan.
Aim: Bacterial infection following ABO-incompatible organ-transplantation is associated with refractory Ab-mediated rejection. Here, we investigated the influence of toll-like receptor (TLR)-signaling, via the binding of…
2015 American Transplant Congress
Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study
F. Eskandary,¹ G. Bond,¹ H. Regele,² N. Kozakowski,² Z. Kikic,¹ M. Wahrmann,¹ H. Haslacher,³ R. Oberbauer,¹ V. Ramassar,⁴ P. Halloran,⁴ G. Böhmig.¹
¹Nephrology and Dialysis, Medical University Vienna, Vienna, Austria; ²Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria; ³Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria; ⁴4Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…
2015 American Transplant Congress
B7-H1 Deficiency in Liver Allografts Leads to CD8-Mediated Acute Vascular Rejection
M. Morita, D. Joyce, J. Fung, S. Qian, R. Fairchild, L. Lu.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Clevland Clinic, Cleveland, OH.
The liver is a unique organ in that it is accepted across complete MHC mismatch in allotransplantation in a number of species. The mechanisms behind…
2015 American Transplant Congress
Investigation of Myocardial Function in Pediatric Transplant Recipients
K. Sgambat, S. Clauss, M. Lasota, A. Moudgil.
Children's National, Washington, DC.
Purpose: In light of the major impact of cardiovascular morbidity on long-term transplant outcomes, a prospective controlled study was conducted to investigate changes in myocardial…
2015 American Transplant Congress
Adoptive Transfer of T Cell Receptor-Transgenic (TCR-Tg) Cells Alters Endogenous Immune Responses During Acute Rejection
M. Miller, M. Daniels, Y. Wang, D. Yin, A. Chong, M.-L. Alegre.
University of Chicago, Chicago, IL.
In addition to the therapeutic use of adoptive transfer of T cells to combat viral infections and malignancies in humans, adoptive transfer of T cell…
2015 American Transplant Congress
Immunoglobulin G Donor-Specific Anti-HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury
D. Viglietti,^1,2 C. Bentlejewski,³ J.-P. Duong van Huyen,^4,2 D. Vernerey,^5,2 O. Aubert,² J. Verine,¹ X. Jouven,² C. Legendre,⁴ D. Glotz,¹ A. Loupy,^2,4 A. Zeevi,³ C. Lefaucheur.^1,2
¹Saint-Louis Hospital, Paris, France; ²Paris Translational Research Center for Organ Transplantation - INSERM U970, Paris, France; ³University of Pittsburgh Medical Center, Pittsburgh; ⁴Necker Hospital, Paris, France; ⁵CHRU de Besançon, Besançon, France.
Experimental and clinical data suggest that antibodies have different pathogenicities according to their IgG subclasses. We investigated the association between IgG subclasses of circulating anti-HLA…
2015 American Transplant Congress
Outcomes Associated With Carbapenem-Resistant Klebsiella Pneumoniae (CRKP) in Solid Organ Transplant (SOT) Recipients
T. Bias,¹ A. Sharma,² G. Malat,³ D. Lee,² A. Doyle.²
¹Dept of Pharmacy, Hahnemann University Hospital, Philadelphia; ²Dept of Medicine, Drexel University, College of Medicine, Philadelphia; ³Dept of Surgery, Drexel University, College of Medicine, Philadelphia, PA.
Background: Infection with CRKP is emerging as an important challenge among SOT recipients. Our study aims to describe the epidemiology and clinical outcomes associated with…