Am J Transplant, Volume 5, Suppl 3 Archives - Page 160 of 170 - ATC Abstracts

2015 American Transplant Congress
The Impact of Hypertension, Chronic Pain, and Fatigue on Long-Term Quality of Life After Living Kidney Donation
T. Schachtner,^1,2 P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charité Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.
The rising prevalence of end-stage renal disease and Germany's chronic organ shortage subsequently calls more people upon to consider living kidney donation. The benefits for…
2015 American Transplant Congress
C1q Reactivity and IgG Subtypes After HLA Antibody Removal Therapy With Carfilzomib in Thoracic Transplant Recipients
A. Zeevi, M. Marrari, C. Bentlejewski, J. Pilewski, M. Morrell, J. McDyer, M. Shullo, J. Teuteberg, C. Bermudez, C. Ensor.
Univ of Pittsburgh, Pittsburgh.
Conventional therapies for antibody removal consisting of plasma exchange with IVIG and Rituximab are partially effective in desensitization protocols and for treatment of antibody mediated…
2015 American Transplant Congress
CYP3A4 Polymorphisms Correlate With Time to Achieve Tacrolimus Steady State Concentration in Lung Transplant Patients
I. Timofte, A. Iacono, J. Kim, P. Sanchez, R. Reed, K. Rajagopal, M. Mclenon, B. Griffith, R. Pierson, S. Pham.
Pulmonary and Critical Care, University of Maryland, Baltimore; Surgery, University of Maryland, Baltimore.
Introduction:Tacrolimus is the main component of the immunosuppressive regimen used in patients with solid organ transplants. Tacrolimus requires blood concentration monitoring due a narrow therapeutic…
2015 American Transplant Congress
Elevated Pre-Transplant Serum Troponin Is Associated With an Increased Risk of Mortality in Elderly Kidney Transplant Recipients
G. Desbuissons,¹ J. Golmard,² H. Lazareth, M. Timsit,³ H. Kreis, D. Anglicheau, C. Legendre,¹ R. Snanoudj,¹ F. Martinez.¹
¹Service de Néphrologie et Transplantation Adulte, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; ²Hôpital Pitié-Salpétrière, Paris, France; ³Service d'Urologie, HEGP-Necker, Assistance Publique-Hôpitaux de Paris, Paris, France.
Introduction:Elderly patients with chronic kidney disease are nowadays more often considered for kidney transplantation although death rate is increased in this population compared to younger…
2015 American Transplant Congress
Proteomic Study Identified a Distinct Panel of Protein Expression in the ATP-Competitive MTOR Kinase Inhibitor Conditioned Dendritic Cells Compared to Rapamycin
T. Ma,¹ Y. Pei,¹ Y. Han,² R. Tao.¹
¹Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; ²Department of Pathology, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China.
Purpose: Dendritic cells (DCs) are key players in both innate and adaptive immunity, as well as in immune tolerance. The mammalian target of rapamycin (mTOR)…
2015 American Transplant Congress
Murine Veno-Arterial Extracorporeal Membrane Oxygenation (mVA-ECMO): A Novel Tool to Study the Molecular Biology of Mechanical Circulatory Support
A. Schenk,¹ J. Fallon,¹ M. Farrell,¹ R. Halter,² J. Yun.³
¹Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH; ²Thayer School of Engineering, Dartmouth College, Hanover, NH; ³Cardiothoracic Surgery, Yale New-Haven Hospital, New Haven, CT.
PURPOSE: In recent years, clinical use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has grown. Extracorporeal circulation is an essential component of heart and lung transplantation,…
2015 American Transplant Congress
Effects of the Allo-Immune Response On Nerve Regeneration in Vascularized Composite Allotranplantation
S. Tuffaha,¹ J. Budihardjo,¹ P. Afrooz,² K. Sarhane,¹ R. Jindal,² D. Cooney,¹ G. Brandacher,¹ W. Lee.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins Medical Institutions, Baltimore, MD; ²Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Purpose: Unlike solid organ transplantation, VCA relies on adequate nerve regeneration for graft function. There is a lack of understanding regarding how the alloimmune response…
2015 American Transplant Congress
Effects of Immunosuppressives On Porcine Renal Microvascular Endothelial Cell–Activated Human T Cell Proliferation: A Cellular Model of Kidney Xenotransplantation In Vitro
Z.-Y. Wang, M. Tector, S. Nagai, J. Butler, R. Blankenship, S. Downey, J. Estrada, P. Li, A. Tector.
Surgery, Indiana University School of Medicine, Indianapolis, IN.
Background: The creation of genetically-modified pigs has brought us closer than ever to clinical xenotransplantation. However, the optimal immunosuppressive doses still need to be established…
2015 American Transplant Congress
Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation
J. Marino,¹ P. Crosby Bertorini,¹ M. Uehara,² J. Paster,¹ S. Mordecai,³ W.-H. Liu,¹ L. Liu,¹ R. Abdi,² G. Tocco,¹ J. Kim,¹ J. Markmann,¹ G. Benichou.¹
¹Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA; ²Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA; ³Department of Pathology, Flow and Imaging Cytometry Core, Massachusetts General Hospital, Boston, MA.
We have studied the kinetics of donor cell trafficking from the graft to recipient's lymphoid organs and its correlation to the direct T cell alloresponse…
2015 American Transplant Congress
mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia
I. Werner, A. Hernandez-Sierra, F. Guo, A. Moritz, A. Beiras-Fernandez.
Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany.
ObjectivemTOR inhibitors Everolimus and Sirolimus are currently used as maintenance immunosuppressive agents to prevent rejection of solid transplanted organs. Episodes of transplant rejection and graft…