2015 American Transplant Congress
LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection
1Surgery, Emory Transplant Center, Atlanta, GA; 2Surgery, Duke University, Durham, NC.
[Background] Lymphocyte depletion prior to transplantation is beneficial in reducing initial maintenance immunosuppression in transplantation. However, despite its excellent efficacy in controlling T cell mediated…2015 American Transplant Congress
Peritransplant Costimulation Blockade and Rapamycin Therapy Induces Permanent Limb Allograft Survival
Aim: Using murine models, we sought to identify the mechanisms of responsible for vascularized composite allotransplant (VCA) rejection, and to thereafter, using clinically relevant peri-transplant…2015 American Transplant Congress
Characteristics and Outcomes of Renal Transplant Recipients With Hemolytic Uremic Syndrome: An OPTN Registry Analysis
Hemolytic uremic syndrome (HUS) accounts for <1% of renal transplants in the US. There is limited data on the characteristics and outcomes of in pediatric…2015 American Transplant Congress
Increased Cytotoxic and Regulatory T Cell and B Cell Associated Gene Transcripts in Transplant Kidney Biopsies With Non-Specific IFTA and Interstitial Inflammation
Background: Patients with non –specific interstitial fibrosis/tubular atrophy (IFTA) have lower graft survival if their biopsies have interstitial inflammation, described as “ i” in Banff…2015 American Transplant Congress
Everolimus and Early Calcineurin Inhibitor Withdrawal Is Associated With Superior Renal Function: 5-Year Follow-Up of the Randomized PROTECT Liver Transplantation Study
PROTECT Study Group, Novartis Pharma GmbH, Germany.
Purpose: At the end of the 12-month (M) PROTECT core study (NCT00378014), de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)…2015 American Transplant Congress
Epstein Barr Virus Modulates Host Cell MicroRNA-194 to Promote IL-10 Production in B Cell Lymphomas
Surgery/Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA.
Epstein Barr virus (EBV) infection is associated with the development of post-transplant lymphoproliferative disorder (PTLD) which can manifest as aggressive B cell lymphomas in transplant…2015 American Transplant Congress
Allogeneic Mature Human Monocyte-Derived Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in an IL-2-Independent Manner
IntroductionExpansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different…2015 American Transplant Congress
Impact of Delayed Graft Function and Number of Dialysis Sessions on Graft Outcome After Kidney Transplantation
Dep.of Nephrology Charité Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
IntroductionDelayed graft function (DGF), defined as dialysis within the first week after kidney transplantation, is a common and known risk factor for impaired renal graft…2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…2015 American Transplant Congress
Excellent Outcomes With Deceased Donor Kidney Transplants With a Terminal Creatinine >= 3
Purpose: Kidneys from deceased donors with elevated creatinine are frequently discarded due to concerns about poor post-transplant outcomes. In this study we sought to determine…
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