Am J Transplant, Volume 5, Suppl 3 Archives - Page 152 of 170 - ATC Abstracts

2015 American Transplant Congress
Bridging Therapy With Belatacept in High MELD Liver Transplant Recipients
T. Sparkes,¹ B. Masters,¹ S. Hanish,² D. Potosky,² W. Hutson,² J. LaMattina,² R. Barth.²
¹University of Maryland Medical Center, Baltimore; ²University of Maryland School of Medicine, Baltimore.
Background: Poor outcomes of high-MELD liver transplant recipients are driven by multisystem organ dysfunction. Renal failure post-transplant has been associated with mortality of greater than…
2015 American Transplant Congress
Hospital Re-Admission After Intestinal Transplantation
Y. Kwon,¹ R. Girlanda,¹ A. Sharp,² K. Etesami,¹ J. Hawksworth,¹ C. Desai,¹ E. Island,¹ C. Matsumoto,¹ T. Fishbein.¹
¹MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC; ²Georgetown University School of Medicine, Washington, DC.
Aim. Intestinal transplant (ITx) recipients frequently require repeat hospital admissions after successful transplant, increasing costs and causing significant burden on families. The causes of hospital…
2015 American Transplant Congress
Is BK Viral Subtype Distribution of Donor And/Or Recipient Important for Subsequent BK Viral Infection After Living-Donor Transplantation?
A. Schwarz,¹ S. Linnenweber-Held,¹ H. Haller,¹ A. Heim,² C. Schmitt.²
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Virology, Hannover Medical School, Hannover, Germany.
Background: Source and risk factors for developing BK virus (BKV) infection after renal transplantation are unresolved. By genotyping of urine and blood, we looked for…
2015 American Transplant Congress
External Validation of Clinical Prediction Models of Patient and Graft Survival in a Canadian Cohort of Kidney Transplant Recipients
S. Singh,^1,2 D. Naimark,^1,2,3 J. Victor,² J. Kim.^1,2,4,5
¹Division of Nephrology, Department of Medicine, University of Toronto, Toronto, ON, Canada; ²Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; ³Division of Nephrology, Sunnybrook Health Sciences Center, Toronto, ON, Canada; ⁴Division of Nephrology and the Kidney Transplant Program, University Health Network, Toronto, ON, Canada; ⁵Division of Nephrology and the Renal Transplant Program, St. Michael's Hospital, Toronto, ON, Canada.
Background: Several clinical prediction models (CPM) of patient and graft survival in kidney transplant recipients have been developed as tools to assist physicians in identifying…
2015 American Transplant Congress
Characteristics and Consequences of Renal Allograft Rejections Due to Nonadherence
S. Patel, S. Kuten, J. Everett, J. Loucks-DeVos, L. Gaber, A. Gaber, R. Knight.
Houston Methodist Hospital, Houston.
Non-adherence (NA) with immunosuppressive medications is associated with increased healthcare costs, rejection risk, and graft loss. NA is difficult to measure, however, and is often…
2015 American Transplant Congress
Targeted Silencing of TLR Adaptor Genes Using Mannose Liposome to Prolong Cardiac Allograft Survival
X. Zhang,¹ J. Jiang,² X. Zheng,¹ J. Shi,³ T. Zwiep,¹ N. Johnston,¹ D. Quan,^1,2 W.-P. Min.^1,2,3
¹Department of Surgery, Pathology and Oncology, Western University, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Jiangxi Academy of Medical Sciences, The First Affiliated Hospital, and Institute of Immunotherapy of Nanchang, NanChang, Jiangxi, China.
Background: MyD88 and TRIF, the common adaptors of Toll-like receptors (TLRs) signaling, evoke dendritic cells (DCs)-mediated antigen-specific immune rejection. Abolish TLR-induced adaptive immune response in…
2015 American Transplant Congress
Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts
M. Tonsho,¹ G. Benichou,¹ R. Smith,² R. Colvin,² J. Madsen.^1,3
¹MGH Transplant Center, Massachusetts General Hospital, Boston, MA; ²Pathology, Massachusetts General Hospital, Boston, MA; ³Cardiac Surgery, Massachusetts General Hospital, Boston, MA.
Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…
2015 American Transplant Congress
Rewarming of Cold Preserved Livers Decreases Graft Injury and Kupffer Cell Activation by Normothermic Extracorporeal Liver Perfusion (NELP)
B. Banan,¹ R. Watson,² Y. Lin,¹ J. Jia,¹ Z. Xiao,¹ G. Upadhya,¹ W. Chapman.¹
¹Surgery, Washington University School of Medicine, St Louis, MO; ²Anatomic & Molecular Pathology, Washington University School of Medicine, St Louis, MO.
Normothermic extracorporeal liver perfusion (NELP) is able to decrease ischemia reperfusion injury to the greatest degree when cold ischemic time is minimized. However, given the…
2015 American Transplant Congress
High-Resolution Perfusion Mapping to Detect Heart Transplant Rejection Using Contrast Enhance Ultrasound
K. Fischer,^1,2 S. Ohori,² F. Meral,¹ S. Giannini,² K. Hoffmeister,² H. Athar,² T. Ichimura,² R. Smith,³ M. Giverts,² F. Jolesz,¹ R. Abdi.²
¹Radiology, Brigham and Women's Hospital, Boston; ²Medicine, Brigham and Women's Hospital, Boston; ³Pathology, Massachusetts General Hospital, Boston.
Background: One of the key unmet needs in heart transplantation is an effective and accurate, non-invasive tool to diagnose acute and chronic heart transplant rejection.…
2015 American Transplant Congress
Losartan Benefits Are Mediated Through SIRT1 Activation in Rat Reduced Size Orthotopic Liver Transplantation
E. Pantazi,¹ M. Bejaoui,¹ M. Zaouali,¹ E. Folch-Puy,¹ A. Rolo,^2,3 A. Panisello,¹ C. Palmeira,² J. Rosello-Catafau.¹
¹Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain; ²Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal; ³Center for Neurosciences and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal.
Background: Silent Information Regulator 1 (SIRT1) is a histone deacetylase that has been associated with protective mechanisms against IRI, but its role in liver transplantation…