Am J Transplant, Volume 5, Suppl 3 Archives - Page 149 of 170 - ATC Abstracts

2015 American Transplant Congress
Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model
G. Furtmüller,¹ N. Crane,² R. Luthra,² E. Swanson,¹ H.-T. Cheng,¹ B. Oh,¹ M. Fryer,¹ E. Elster,² W. Lee,¹ G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD.
Purpose: To evaluate imaging modalities such as 3CCD and infrared (IR) technology as a means of non-invasive monitoring of graft acceptance and rejection in the…
2015 American Transplant Congress
Assessment of Viral-Specific Memory T Cell Responses and Infection Rates in HLA-Sensitized (HS) Kidney Transplant Patients (Tx Pts) Treated With Everolimus & Low-Dose Tacrolimus (Eve/Tac)
S. Ge, J. Kahwaji, M. Chu, A. Karasyov, M. Castro, E. Hayrapetyan, D. Lovato, D. Thomas, J. Choi, S. Louie, A. Vo, S. Jordan, M. Toyoda.
Transplant Immunology & Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles.
Background: mTOR inhibitors stimulate viral-specific memory CD8+ T cell differentiation and increase viral clearance in infected Tx pts. HS pts desensitized (DES) with IVIG +…
2015 American Transplant Congress
Impact of Serial Change of Donor Specific Antibodies On the Graft Outcomes After Liver Transplantation
D. Joo,^1,2 J. Lee,³ J. Lee,^1,2 J. Lee,^1,2 S. Kim,⁴ D. Han,^1,2 M. Ju,^1,2 J. Choi,^1,2 S. Kim,^1,2 M. Kim.^1,2
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; ³Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea; ⁴Department of Surgery, Wonju Yonsei University College of Medicine, Wonju, Korea.
Introduction: This study aimed to investigate the acute rejection rate and graft function after liver transplantation according to pre-transplantation donor specific antibody (DSA) status and…
2015 American Transplant Congress
Activation of Th17 and Chronic Renal Allograft Rejection in Nonhuman Primates
K. Hotta, A. Aoyama, P. Putheti, Y. Yamada, T. Ohura, R. Colvin, B. Cosimi, G. Benichou, T. Strom, T. Kawai.
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Although donor specific Th1 and…
2015 American Transplant Congress
Comprehensive Study of 3 Nomenclatures to Discriminate CD8 Subsets in Healthy Volunteers and in Kidney Transplant Recipients
M. Yap,^1,3 G. Tilly,^1,3 M. Giral,^1,2 S. Brouard,^1,2 N. Degauque.^1,2
¹UMR 1064, INSERM, Nantes, France; ²ITUN, CHU de Nantes, Nantes, France; ³Faculté de Médecine, Université de Nantes, Nantes, France.
Objective. Historical classification to distinguish central memory (CM), naïve, effector memory (EM), and terminally-differentiated effector memory (TEMRA) CD8 T cells is based on CD45RA and…
2015 American Transplant Congress
Pyridoxine Deficiency After Solid Organ Transplant
S. Van Arsdale,¹ S. Yost,² M. Meer,¹ S. Schoentag,¹ P. Kadambi,³ S. Habib.³
¹Department of Nutrition Services, University of Arizona Medical Center, Tucson, AZ; ²Department of Pharmacy, University of Arizona Medical Center, Tucson, AZ; ³Department of Medicine, University of Arizona College of Medicine, Tucson, AZ.
BackgroundMicronutrient deficiencies have been discussed in the literature regarding post-transplant recipients. A proposed theory is that immunosuppressive medications or altered immune system cause pyridoxine deficiency…
2015 American Transplant Congress
Identification of Strategies to Facilitate Organ Donation Among African Americans
J. Locke,¹ H. Qu,² R. Shewchuk,² D. Segev,³ M. Martin.⁴
¹Surgery/Transplantation, University of Alabama at Birmingham, Birmingham, AL; ²Health Services Administration, University of Alabama at Birmingham, Birmingham, AL; ³Epidemiology, Johns Hopkins University, Baltimore, MD; ⁴Medicine/Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL.
Background: African Americans (AA) are disproportionately affected by renal disease, yet few receive a kidney transplant. Surveys assessing attitude toward donation have demonstrated that AAs…
2015 American Transplant Congress
Human Bone Marrow Mesenchymal Stem Cell-Derived Hepatocytes Express TIMP-4 and Follistatin
J. Li,¹ J. Xin,¹ W. Ding,² S. Hao,¹ L. Jiang,¹ Q. Zhou,¹ T. Wu,¹ D. Shi,¹ L. Li.¹
¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China; ²Systems Biology Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, HangZhou, China.
Human bone marrow mesenchymal stem cell (hBMSC) transplantation has been expected to be an alternative regenerative technique for liver diseases. However, the mechanism by which…
2015 American Transplant Congress
Non-Invasive Immune Monitoring Assay in Transplant Recipients
M. Gasser,¹ I. Tsaur,² K. Lopau,¹ C. Germer,¹ A. Chandraker,³ A. Waaga-Gasser.¹
¹Department of Surgery I, University of Wuerzburg, Wuerzburg, Germany; ²Department of Urology, University of Frankfurt, Frankfurt, Germany; ³Transplantation Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
A reliable non-invasive assay of immune responsiveness would help to predict the development of chronic rejection, stable function or tolerance in transplant recipients. Our aim…
2015 American Transplant Congress
Low Molecular Weight Hyaluronan Increases MIG and MCP-1 Production in Cardiac Allografts
S. Goparaju,¹ A. Kaul,¹ N. Dvorina,¹ S. Iida,¹ K. Keslar,¹ R. Fan,¹ C. de la Motte,² A. Valujskikh,¹ R. Fairchild,¹ W. Baldwin III.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Pathobiology, Cleveland Clinic, Cleveland, OH.
Macrophages engage in extracellular matrix remodeling both degrading and synthesizing hyaluronan. Hyaluronan is a high molecular weight ( > 1000 kDa) extracellular matrix component that…