ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Can Gene-Expression Profiling Score Help Explain the Adverse Clinical Outcomes Seen in Gender-Mismatched Heart Transplants?

    N. Sulemanjee,1 P. Prasad,2 T. Wolf,2 V. Thohan,1 J. Teuteberg.3

    1Aurora Research Institute, St. Luke's Medical Center, Milwaukee, WI; 2CareDx, Inc., Brisbane, CA; 3University of Pittsburgh Medical Center, Pittsburgh, PA.

    Background: Gene-expression profiling (GEP) testing, in conjunction with clinical assessment, is an established laboratory test intended to aid in the identification of acute cellular rejection…
  • 2015 American Transplant Congress

    Boosting the Adaptive Immune Response Prevents the High Incidence of Herpes Zoster After Lung or Heart Transplantation

    N. van Besouw,1 S. Roest,2 J. Zuijderwijk,1 R. de Kuiper,1 J. van Weezel,3 A. van der Eijk,4 W. Weimar,1 P. Hal,3 O. Manintveld.2

    1Internal Medicine - Transplantation, Erasmus MC, Rotterdam, Netherlands; 2Cardiology, Erasmus MC, Rotterdam, Netherlands; 3Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; 4Viroscience, Erasmus MC, Rotterdam, Netherlands.

    Purpose Primary varicella zoster virus (VZV) infection causes varicella and lifelong latent infection in ganglia from which it may reactivate leading to herpes zoster (HZ).…
  • 2015 American Transplant Congress

    Can Post-Transplant C-Peptide Be Used as an Indicator of Pancreas Graft Failure?

    R. Carrico,1 J. Fridell,2 J. Odorico,3 R. Stratta,4 K. Tyler,1 S. Niederhaus,5 R. Kandaswamy,6 J. Fisher,7 O. Olaitan,8 M. Mujtaba.2

    1UNOS, Richmond, VA; 2Indiana Univ School of Medicine, Indianapolis, IN; 3Univ Wisconsin Hospital and Clinics, Madison, WI; 4Wake Forest Baptist Medical Center, Winston-Salem, NC; 5Univ of Maryland Medical System, Baltimore, MD; 6Univ of MN Medical Center, Minneapolis, MN; 7Scripps Green Hospital, La Jolla, CA; 8Rush Univ Medical Center, Chicago, IL.

    Background: The OPTN Pancreas Transplantation Committee is attempting to define pancreas graft failure and performed a study to determine if C-peptide corresponds to pancreas graft…
  • 2015 American Transplant Congress

    Screening Recipients of Increased Risk Donor Organs: A Multicenter Study

    N. Theodoropoulos,1 K. Brizendine,2 M. Ison.3

    1Infectious Diseases, The Ohio State University, Columbus, OH; 2Infectious Disease, Cleveland Clinic, Cleveland, OH; 3Infectious Diseases/Organ Transplantation, Northwestern University, Chicago, IL.

    Purpose: Policy mandates post-transplant (tx) evaluation of recipients of increased risk donor organs (ROIRDO). PHS guidelines recommend that screening include HIV & hepatitis C virus…
  • 2015 American Transplant Congress

    Non-Invasive Panel of MicroRNAs Predict Long-Term Outcomes Post-Kidney Transplantation

    J. Suh,1 D. Maluf,1 H. Cathro,2 R. Gehrau,1 I. McConnell,1 K. Brayman,1 C. Dumur,2 V. Mas.1

    1Surgery and Pathology, UVA, Charlottesville, VA; 2VCU, Richmond, VA.

    Background. Currently available methods for evaluating kidney graft function post-transplantation (KT) are either ineffective or inaccurate (e.g., serum creatinine) or highly invasive (e.g., biopsies). We…
  • 2015 American Transplant Congress

    Changes in Health Related Quality of Life (HRQOL) in Pediatric Liver Transplant (LT) Recipients During Protocolized Immunosuppression Withdrawal (ISW): The iWITH Trial

    S. Mohammad,1 S. Sundaram,2 V. Venkat,3 M. Martinez,4 J. Lopez,5 J. Magee,5 E. Alonso,1 S. Feng.6

    1Northwestern U, Chicago; 2U of Colorado, Aurora; 3U of Pittsburgh, Pittsburgh; 4Columbia U., New York; 5U of Michigan, Ann Arbor; 6UCSF, San francisco.

    ISW may limit medication-related comorbidities but intensive monitoring and unexpected rejection episodes may compromise HRQOL. We studied longitudinal HRQOL in pediatric LT recipients undergoing ISW…
  • 2015 American Transplant Congress

    The Selection Process for Total Artificial Heart

    F. Arabia, L. Czer, M. Kittleson, E. Passano, F. Liou, J. Yabuno, H. Henry, D. Chang, F. Esmailian, J. Kobashigawa, J. Moriguchi.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: Heart failure patients with severe biventricular failure who are candidates for heart transplant are considered for Total Artificial Heart (TAH) support. These patients may…
  • 2015 American Transplant Congress

    Failure to Account for Critical Candidate Characteristics Significantly Biases Kidney Transplant Center Report Cards Measuring Time to Transplant

    L. Kayler,1 J. Schold.2

    1Surgery, Montefiore Medical Center, Bronx, NY; 2Medicine, Cleveland Clinic, Cleveland, OH.

    Kidney transplant rate is proposed to be integrated into the new composite metric to evaluate center performance. Current methods adjust for PRA, blood type, re-transplantation,…
  • 2015 American Transplant Congress

    Association Between Histological Abnormalities in Time-Zero Renal Biopsies and Post-Donation eGFR in Live Donors

    L. Fahmy, A. Massie, B. Orandi, S. Bagnasco, J. Alejo, B. Boyarsky, S. Anjum, R. Montgomery, N. Dagher, D. Segev.

    Johns Hopkins, Baltimore.

    Time-zero biopsies (T0-RBx) of live-donor kidneys may reveal histological abnormalities at the time of organ recovery. The association between T0-RBx and subsequent kidney function in…
  • 2015 American Transplant Congress

    Comparison of T Regulatory (Treg) Cell Function Pre- and Post-Lung Transplantation Shows a Major Negative Impact of Immunosuppression on Treg Function

    T. Akimova,1 J. Diamond,2 D. Wilkes,3 D. Lederer,4 J. Christie,2 W. Hancock.1

    1Path & Lab Med, CHOP & UPenn, Philadelphia; 2Pulm, Allergy & Crit Care Med, UPenn, Philadelphia; 3Med, Microbiol & Immunol, Indiana Uni Sch of Med & Thoracic Transplant Prog, Indianapolis; 4Medicine, Columbia Uni, New York.

    Aim: Clinical lung Tx recipients do not have sustained long-term survival outcomes comparable to that of other recipients of solid organ allografts, despite generally comparable…
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