Am J Transplant, Volume 5, Suppl 3 Archives - Page 145 of 170 - ATC Abstracts

2015 American Transplant Congress
The Impact of Delayed Graft Function (DGF) and Acute Rejection (AR) on the Decline in Allograft Function After Kidney Transplantation
J. Gill, J. Dong, C. Rose, J. Gill.
Nephrology, University of BC, Vancouver, BC, Canada.
Delayed Graft Function (DGF) and Acute Rejection (AR) are associated with an increased risk of graft loss. It is unclear whether this is a result…
2015 American Transplant Congress
ABO Incompatible Simultaneous Liver-Kidney Transplant With Positive Crossmatch. A Case Report
T. Heffron,¹ C. Kulig,² P. Gauthier,² B. Bista,² S. Dionne,³ T. Pillen,¹ M. Asolati.¹
¹Surgery, Porter Adventist Hospital, Denver, CO; ²Medicine, Porter Adventist Hospital, Denver, CO; ³LABS, Inc., Centennial, CO.
INTRODUCTION: Donor Specific (DS) antibodies and ABO incompatibility remain major immunological barriers in organ transplantation. Clinical evidence suggest the liver can protect a kidney from…
2015 American Transplant Congress
The Impact of Metabolic Syndrome and Prevalent Liver Disease on Living Donor Liver Transplantation: A Pressing Need to Expand the Pool
W. Al-hamoudi,^1,2 F. Abaalkhail,² A. Bendahmash,¹ N. Allam,² N. Almasri,² H. Al-Bahili,² M. Al-Sebayel,² D. Broering,² H. Elsiesy.²
¹Gastroenterology and Hepatology Department, King Saud University, Riyadh, Saudi Arabia; ²2Department of Liver Transplantation and Hepatobiliary Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Background and Aims: Organ shortage has been the ongoing obstacle to expand liver transplantation world-wide. Living donor liver transplantation (LDLT) was hoped to improve this…
2015 American Transplant Congress
Preserved Kidney Volume in Living Kidney Donors: Correlation With 2 Year Renal Function Using CKD-EPI Equation to Predict Remaining GFR
A. Khalil,¹ M. Yaqub,¹ T. Taber,¹ J. Powelson,¹ C. Sundaram,¹ W. Goggins,¹ D. Mishler,¹ M. Mujtaba,¹ A. Diez,² A. Sharfuddin.¹
¹Indiana University; ²Ohio State University, Columbus.
Background: The aim of our study was to evaluate whether preserved kidney volume correlates with donor renal function at 2-years post-donation using the CKD-EPI eGFR…
2015 American Transplant Congress
Quantifying Altruism in Kidney Donors: How Good Are the Current Scales?
M. McLaughlin, D. Berglund, A. Matas, H. Ibrahim.
U of MN, Mpls.
The decision to become a living kidney donor is complicated and altruism is certainly what drives the majority of organ donors. Unfortunately, there are no…
2015 American Transplant Congress
Lung Transplantation from Donors With Kidney Disease
A. Ganapathi, B. Gulack, A. Castleberry, R. Davis, L. Snyder, M. Hartwig.
Duke University Medical Center, Durham, NC.
Background:Various donor characteristics are associated with decreased survival following single (SLT) or bilateral (BLT) lung transplantation. No current studies exist regarding use of lungs from…
2015 American Transplant Congress
Excellent Outcomes With Kidney Transplantation for Patients ≥70 Years of Age
D. Haakinson,¹ K. Reddy,¹ A. Moss,¹ N. Katariya,¹ A. Singer,¹ A. Mathur,¹ J. Huskey,² H. Khamash,² R. Heilman.²
¹Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ; ²Nephrology, Mayo Clinic Arizona, Phoenix, AZ.
BackgroundOur aim was to determine the outcomes following kidney transplantation in recipients ≥70 years of age at the time of transplantation.Materials and MethodsWe analyzed data…
2015 American Transplant Congress
Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)
R. Catar,¹ C. Luecht,¹ M. Simon,¹ A. Philippe,¹ A. Kusch,¹ M. Szczepek,² P. Hildebrand,² P. Scheerer,² D. Dragun.¹
¹Nephrology and Intensive Care Medicine, Charité, Berlin, Germany; ²Institute of Medical Physics and Biophysics, Charité, Berlin, Germany.
Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…
2015 American Transplant Congress
Pharmacogenetic Variation in Renal Calcineurin Inhibitor (CNI) Metabolism and the Response of Allograft-Derived Proximal Tubule Cells
N. Knops,^1,2 L. van den Heuvel,² R. Masereeuw,³ H. de Loor,⁴ E. Levtchenko,^1,2 D. Kuypers.^5,4
¹Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Laboratory for Pediatrics, Dept. Development & Regeneration, KU Leuven, Leuven, Belgium; ³Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands; ⁴Laboratory of Nephrology, University Hospitals Leuven, Leuven, Belgium; ⁵Nephrology and Solid Organ Transplantation, University Hospital Leuven, Leuven, Belgium.
Background: Multiple studies have demonstrated the importance of genetic variation in CYP3A5 and ABCB1 for calcineurin inhibitor (CNI) disposition and CNI-related nephrotoxicity. Renal CNI metabolism…
2015 American Transplant Congress
Accurate Prediction of High-Resolution HLA-A, -B, -C, -DRB1 and -DQB1 Typing and Low-Resolution HLA-DQA1 Typing by Haplotype Analysis
A. Jaramillo,¹ R. Vaidya,² M. Pando,³ S. Gaitonde.⁴
¹Histocompatibility & Immunogenetics Laboratory, Gift of Hope Organ & Tissue Donor Network, Itasca, IL; ²College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT; ³Department of Laboratory Medicine & Pathology, Mayo Clinic, Phoenix, AZ; ⁴Department of Pathology, University of Illinois, Chicago, IL.
Aim: Allele-specific HLA antibodies are commonly detected by Luminex single antigen bead assays in solid organ transplant recipients. However, high-resolution HLA typing for deceased donors…