2015 American Transplant Congress
VLA-4 Blockade Inhibits Endogenous Memory CD8 T Cell-Mediated Rejection of Cardiac Allografts
Endogenous memory CD8 T cells infiltrate cardiac allografts within 24 hours of reperfusion and are activated to proliferate and produce IFN-γ in response to donor…2015 American Transplant Congress
Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure
Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…2015 American Transplant Congress
Serum Proteins Are Significantly Upregulated in Patients With Clinical Antibody-Mediated Rejection
Background: Antibody-mediated rejection (ABMR) is a major pathway associated with late graft loss. Although serum de novo donor-specific HLA antibodies are frequently observed in ABMR,…2015 American Transplant Congress
Long-Term Analysis of a Placebo-Controlled Trial of C1-INH for Prevention of Antibody-Mediated Rejection
Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Desensitization (DES) strategies focus primarily on antibody reduction using IVIG, rituximab ± PLEX to prevent DSA-induced antibody-mediated rejection (ABMR) and rebound B-cell activity. Recently,…2015 American Transplant Congress
Efficacy and Safety of Three Different Treatment Regimen in De Novo Renal Transplant Patients: Month 48 Follow-Up Results of the HERAKLES Trial
Aim: To compare safety and efficacy of 3 different immunosuppressive (IS) regimen 4years after renal transplantation (Tx).Methods: 802 patients (pts) were included in this 1year,…2015 American Transplant Congress
Validation of the Model for End-Stage Liver Disease Score Criteria in Liver Transplantation for Acute Flare Up of Hepatitis B in Non-Cirrhotic Liver
Background: Decision of necessity of urgent liver transplantation for acute flare up of hepatitis B in the patients without cirrhosis is difficult. The MELD score…2015 American Transplant Congress
Rational Development of Alloantigen Specific Regulatory T Cell Therapy Requires Insight Into Longevity of Alloimmune Pathways
University of Cambridge, Cambridge, United Kingdom.
IntroductionWe have recently demonstrated that indirect-pathway responses against different alloantigens differ in their strength and longevity; specifically, that indirect responses against MHC class I alloantigen…2015 American Transplant Congress
The Forgotten Cell: Renal Fibroblasts Are Activated By Anti-MHC Class I Antibody
Medicine and Surgery, University of Alabama at Birmingham, Birmingham, AL.
Chronic antibody-mediated (CAMR) rejection remains a major obstacle in the long term survival of kidney transplants, and is associated in part with interstitial fibrosis (IF)…2015 American Transplant Congress
Ischemic Cholangiopathy Following Liver Transplantation from Donation After Circulatory Death Donors: Role of Tissue Plasminogen Activator Flush
Background: Formation of microthrombi within the peribiliary arterial plexus causing necrosis of biliary epithelium may be responsible for ischemic cholangiopathy (IC) after donation after circulatory…2015 American Transplant Congress
Predicting Survival of Deceased Donor Kidneys from Children Under Ten
University of Chicago, Chicago, IL.
Background: The United Network for Organ Sharing (UNOS) has adopted a new allocation algorithm that uses a Kidney Donor Profile Index (KDPI) based on 10…
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