2015 American Transplant Congress
The Higher MFI of De Novo Donor-Specific Anti-HLA Antibodies Is Correlated With Graft Fibrosis Progression in Living Donor Liver Transplantation
Background. It has been shown that the development of de novo donor-specific anti-HLA antibodies (DSA) is associated with poorer graft outcome in kidney transplantation. However…2015 American Transplant Congress
Vascularised Composite Allografts and Intestinal Transplantation: Does the Skin Component Provide a Pre-Rejection Marker for the Visceral Organ?
Oxford Transplant Centre, Oxford University Hospitals, Oxford, United Kingdom.
Introduction: Can the skin component of a synchronously transplanted vascularised composite allograft (VCA) be used as a pre-rejection marker for the intestinal transplant (IT)?Methods: Recipients…2015 American Transplant Congress
Everolimus Conversion to Treat BK Virus Infection in Kidney Transplant Recipients
IntroductionmTORi's reduce BKV large T antigen expression in vitro and are associated with lower rates of BKV infection in clinical studies.MethodsPilot single center, randomized, open-label…2015 American Transplant Congress
Impact of Integrase Inhibitor-Based Antiretroviral Regimen on Outcomes in HIV + Renal Transplant Recipients
Beth Israel Deaconess Medical Center, Boston.
Renal transplant in HIV+ patients (pts) is complicated by high rates of acute rejection (AR). Protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) have…2015 American Transplant Congress
Decline in Living Donor Rates Pervasive Across All Kidney Transplant Candidate Groups
Medicine, University of Virginia, Charlottesville, VA.
Previous analysis by our group showed living donor (LD) transplant rates peaked between 2002 and 2004 and declined thereafter. We sought to understand if this…2015 American Transplant Congress
Upregulation of Heart Transplant IL-33 Is Critical in Cardiac Tissue Repair
Starzl Transplantation Institute, Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA.
Background: IL-33 is tissue-derived cytokine whose primary proposed function is to modulate immune responses when released during injury. Delivery of recombinant IL-33 protects cardiac allografts…2015 American Transplant Congress
Immunosuppression With Anti-CD40 mAb and Rapamycin for Islet and Kidney Co-Transplantation in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: For patients with end-stage renal disease secondary to type 1 diabetes mellitus, islet and kidney co-transplantation can be an ideal transplant option. However, a…2015 American Transplant Congress
Human iPS Cell-Derived Pancreatic β-Cells Correct Hyperglycemia in Diabetic Mice
Type I diabetes (T1D) is an autoimmune disorder that leads to the destruction of pancreatic β-cells. The consequences of T1D are dysregulation of metabolism leading…2015 American Transplant Congress
Bariatric Surgery Prolongs Allograft Survival by Promoting Th2 Conditions
Background: Obesity is linked to chronic low-grade inflammation. We hypothesized that I) obesity will accelerate allograft rejection linked to pro-inflammatory immune responses and that II)…2015 American Transplant Congress
Renal Dysfunction by BK Virus Infection Is Correlated With Activated T Cell Level, Cytokines Level, Gramzymes in Renal Transplantation
Purpose:BK virus (BKV) is known to be associated with nephropathy (BKAN). Here, we investigated the relationships between BKV levels, T-cell activation, cytokines and kidney function…
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