Am J Transplant, Volume 5, Suppl 3 Archives - Page 135 of 170 - ATC Abstracts

2015 American Transplant Congress
Change in Frailty Between Evaluation for Kidney Transplantation and Transplantation
M. McAdams DeMarco, E. King, N. Desai, N. Dagher, B. Lonze, R. Montgomery, D. Segev.
Johns Hopkins, Baltimore, MD.
BACKGROUND: Frailty prevalence is high and predicts early hospital readmission, length of stay and mortality in adults of all ages undergoing kidney transplantation (KT). The…
2015 American Transplant Congress
Are DQA Antibodies Real?
J. Jones, D. Lucas, M. Leffell, A. Zachary.
Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Antibodies specific for HLA-DQ antigens appear to be increasing in frequency in the post-transplant period and are difficult to reduce effectively with desensitization protocols using…
2015 American Transplant Congress
Influence of POR*28 Genotype on Tacrolimus Disposition in Heart Transplant Recipients
T. Alford,¹ R. Page,¹ J. Lindenfeld,² C. Aquilante.¹
¹University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO; ²University of Colorado School of Medicine, Aurora, CO.
Polymorphisms in P450 oxidoreductase (POR) have been shown to modulate CYP3A activity and alter the pharmacokinetics of CYP3A substrates, such as tacrolimus (TAC). The objective…
2015 American Transplant Congress
Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS
W. Oetting,¹ D. Schladt,² W. Guan,¹ A. Israni,² R. Remmel,¹ C. Dorr,² K. Sanghavi,¹ R. Mannon,³ B. Herrera,⁴ A. Matas,¹ D. Salomon,⁵ P. Kwok,⁴ P. Jacobson,¹ for DeKAF Genomics.¹
¹Univ. of Minnesota, Minneapolis; ²Minneapolis Medical Research Foundation, Minneapolis; ³Univ. of Alabama, Birmingham; ⁴Univ. of California, San Francisco; ⁵Scripps Research Center, La Jolla.
African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…
2015 American Transplant Congress
Immunological Evaluation of Acellular Extracellular Matrix Upon Transplantation
M. Ketaki,¹ P. Pradeep,¹ N. Nikhil,¹ G. Dellgren,³ H. Suchitra, M. Olausson.²
¹Laboratory for Transplantation Regenerative Medicine, Surgery, Gothenburg University, Gothenburg, Sweden; ²Department of Surgery, SU/Sahlgrenska University Hospital, SE 41345, Gothenburg, Sweden; ³Cardiothoracic Surgery, Transplant Institute, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
Background : To mitigate the scanty supply of donor organs, porcine tissues can be utilized since, it embrace the potential to accomplish the task of…
2015 American Transplant Congress
Microchimerism-Tolerance “Missing Link”: Exosome Acquisition by Host Dendritic Cells
W. Bracamonte-Baran, E. Jankowska-Gan, Y. Zhou, W. Burlingham.
Surgery, University of Wisconsin, Madison, WI.
Background: widespread maternal microchimerism (MMc) in mice is associated with development of immune regulation, which can be used to predict transplantation tolerance. We recently showed…
2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
T. Ueno,^1,2,3 M. Yeung,¹ M. McGrath,¹ H. Iwamoto,³ Y. Nakamura,³ O. Konnno,³ Y. Kihara,³ T. Yokoyama,³ S. Ono,³ T. Ikeda,³ S. Kawachi,³ B. Ibrahim,¹ A. Chandraker.¹
¹Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…
2015 American Transplant Congress
Educating the Less Prepared: Transplant Knowledge and Decision-Making Differences by Race at Onset of Evaluation
A. Waterman,¹ J. Peipert,¹ S. Brann,² C. Kynard-Amerson,¹ M. Robbins,³ A. Paiva,³ A. Gaber.²
¹David Geffen School of Medicine, UCLA, Los Angeles, CA; ²Methodist J.C. Walter Jr. Transplant Center, Houston, TX; ³University of Rhode Island, Kingston, RI.
Racial minorities have higher rates of kidney failure than Whites but are less likely to receive kidney transplants. This study described each race/ethnic groups' level…
2015 American Transplant Congress
Validating Outcomes Reported to the Organ Procurement and Transplantation Network for Deceased Donor Kidney Recipients
V. Potluri,¹ C. Parikh,² I. Hall,² J. Ficek,² M. Doshi,³ I. Butrymowicz,² F. Weng,⁴ B. Schröppel,⁵ H. Thiessen-Philbrook,⁶ P. Reese.⁷
¹Lankenau Hospital, Philadelphia; ²Yale University School of Medicine, New Haven; ³Wayne State University, Detroit; ⁴Barnabas Health, Livingston, NJ; ⁵University Hospital, Ulm, Germany; ⁶Western University, Ontario, Canada; ⁷University of Pennsylvania, Philadelphia.
Data reported to the Organ Procurement and Transplantation Network (OPTN) is used in kidney transplant research, quality metrics and in policy development, but the accuracy…
2015 American Transplant Congress
Prospective, 6 Month, Open Label, Conversion Study from Mycophenolate Mofetyl to Mycophenolic Acid Evaluating the Severity of Gastro-Intestinal Symptoms and Mycophenolic Acid Urinary Metabolite as a Surrogate Marker of Plasmatic Area Under the Curve
D. Tran,¹ A. Boucher,¹ L. Senécal,¹ V. Pichette,¹ F. Leblond,² S. Collette.¹
¹Nephrology, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada; ²Research Center, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
Introduction: Treatment with mycophenolate mofetil (MMF) often results in adverse gastro-intestinal (GI) events, which can lead to dose reductions that in turn can increase the…