Causes of Poor Renal Function of Kidney Transplants from Uncontrolled Donation After Cardiac Death Donors (UDCDD)
Nephrology, Hospital 12 de Octubre, Madrid, Spain.
Meeting: 2015 American Transplant Congress
Abstract number: C48
Keywords: Donors, Kidney transplantation, non-heart-beating, Renal failure
Session Information
Session Name: Poster Session C: ECD/DCD/high KDPI
Session Type: Poster Session
Date: Monday, May 4, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
INTRODUCTION: Kidneys grafts from UDCDD have higher ischemia injury. It develops in higher primary non function, lower graft survival and worst renal function compared to ideal donors.
AIM: Describe risk factors associated with poor renal function in a group of renal transplants from UDCDD.
MATERIAL AND METHOD: Study population included recipients of kidney transplantation from UDCDD performed in our center with functioning graft at 1 year. We defined poor renal function (PRF) as serum creatinine (SCr) ≥ 2 mg/dL at 1 year from kidney transplantation.
RESULTS: Our center have performed 207 kidney transplants from UDCDD. We excluded 14 (7%) primary non-function and 9 (4%) grafts lost in the first year of evolution. 184 (89%) grafts were functioning at 1 year of transplantation. 13 (7%) patients had SCr≥2 mg/dl (Group I) and 171 (93%) patients had SCrs<2 mg/dL (Group II). Characteristic of two groups are showed in Table.
| Group I: SCr > 2 mg/dL (13 patients) | Group II: SCr < 2 mg/dL (171 patients) | p | |
| Donor gender (male) | 92% (12) | 88% (150) | ns |
| Donor age (years) | 51 (47-54) | 41 (35-50) | < 0.01 |
| Donor SCr (mg/dL) | 1.4 (1.2-1.6) | 1.3 (0.9-1.5) | ns |
| Cold ischemia time (hours) | 14 (9-15) | 11 (9-14) | ns |
| Recipient gender (male) | 92% (12) | 53% (91) | <0.01 |
| Recipient age (years) | 48 (41-58) | 47 (39-56) | ns |
| Recipient weigh (kg) | 78 (74-91) | 70 (60-82) | 0.01 |
| Delayed graft function | 69% (9) | 76% (130) | ns |
| Contralateral functioning kidney at one year | 62% (8) | 85% (146) | 0.04 |
| LDH serum | 1776 (1160-2280) | 1463 (822-2520) | ns |
| SCr at 6 month | 2.3 (2.1-2.8) | 1.4 (1.1-1.7) | 0.01 |
| Graft survival at the end of follow-up | 69% (9) | 99% (169) | <0.01 |
Group I had older donors and more male recipients and higher recipient weight. Group II had a higher rate of functioning renal graft. There was more incidence of acute rejection in Group I. There were differences in SCrs between both groups at sixth moth of evolution. Renal graft survival was worst in Group I.
CONCLUSSIONS: The prevalence of poor renal function at 1 year in renal transplants from UDCDD is low in our center although confers a bad renal graft prognosis. Poor renal function is associated to donor age, non-function of contralateral kidney graft, recipient weigh and gender and acute rejection. A better screening of potencial UDCDD, more adecuate allocation of these kidneys and a lower acute rejection rate could reduce la incidence of poor renal function in renal transplantation from UDCDD.
To cite this abstract in AMA style:
Molina M, González E, Gutiérrez E, Morales E, Hernández E, Sevillano A, Polanco N, Cabrera J, Praga M, Andres A. Causes of Poor Renal Function of Kidney Transplants from Uncontrolled Donation After Cardiac Death Donors (UDCDD) [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/causes-of-poor-renal-function-of-kidney-transplants-from-uncontrolled-donation-after-cardiac-death-donors-udcdd/. Accessed December 2, 2023.« Back to 2015 American Transplant Congress