Am J Transplant, Volume 5, Suppl 3 Archives - Page 131 of 170 - ATC Abstracts

2015 American Transplant Congress
Effect of Extension in Submucosal Ureteral Tunnel to Prevent Vesicoureteral Reflux and Its Impact on the Graft Survival in Kidney Transplantation
T. Inoue,¹ S. Satoh,² M. Saito,¹ K. Numakura,¹ H. Tsuruta,¹ S. Akihama,¹ S. Narita,¹ N. Tsuchiya,¹ T. Habuchi.¹
¹Urology, Akita University, Akita, Japan; ²Center for Kidney Disease, Akita University, Akita, Japan.
Objects: It is plausible that vesicoureteral reflux (VUR) induced by an insufficient length of a submucosal ureteral tunnel leads graft function to deteriorate in kidney…
2015 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Enables Accurate Discrimination of Acute Rejection in Kidney Transplant Patients
O. Bestard,^1,2 T. Sigdel,¹ Y. Ng,¹ S.-C. Hsieh,¹ S. Roedder,¹ N. Dvorak,¹ T. Tran,¹ M. Sarwal.¹
¹Department of Transplant Surgery, UCSF, San Francisco, CA; ²Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, CAT, Spain.
A common rejection module (CRM) consisting of 11 genes expressed on allograft biopsies was recently shown to be highly accurate to discriminate patients undergoing acute…
2015 American Transplant Congress
Alterations in Peripheral Blood B Cell Subpopulations in Kidney Transplant Recipients With DSA
B. Ramaswami,¹ R. Ippolito,² B. Elinoff,¹ M. Marrari,³ K. Hadi,¹ C. Macedo,¹ D. Metes,¹ A. Shields,⁴ R. Alloway,⁵ A. Zeevi,³ F. Lakkis,¹ E. Woodle,⁴ G. Chalasani.^1,2
¹Surgery & STI(1), Medicine(2), Pathology(3), University of Pittsburgh, Pittsburgh; ²Surgery(4) & Medicine(5), University of Cincinnati College of Medicine, Cincinnati.
Peripheral blood B cell subpopulations were assessed over time (1, 3, 6, 9, and 12 months) in living donor kidney transplant recipients undergoing thymoglobulin (n…
2015 American Transplant Congress
Increased Vascular Stiffness in Pediatric Renal Transplant Recipients Despite Normal Kidney Function, Blood Pressure, and Body Mass Index
M. Seifert,^1,2 N. Kulsum-Mecci,² L. de las Fuentes,² V. Davila-Roman,² K. Hruska.²
¹Southern Illinois University, Springfield, IL; ²Washington University, St. Louis, MO.
Background: Chronic kidney disease (CKD) imparts enormous cardiovascular (CV) risk that is only partially improved by renal transplantation. We sought to understand the determinants of…
2015 American Transplant Congress
Early Detection of HCC Mutations in Indeterminate Lesions Using Liquid Biopsies
Y. Lin,¹ K. Cavaness,² Z. Zhang,¹ S. Lin,³ K. Korenblat,¹ G. Klintmalm,² W. Chapman.¹
¹Washington University, St. Louis, MO; ²Baylor University, Dallas, TX; ³Stanford University, Palo Alto, CA.
Background Recent sequencing efforts have characterized the mutation profile of hepatocellular carcinoma (HCC); however, the relevance to clinical decision-making has been limited by the infrequency…
2015 American Transplant Congress
Expression Patterns of Neuropilin-1 On T Cells and a Potential Role in Transplantation
E. Lee, H. Kim, G. Demirci.
Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a co-receptor for a variety of ligand families including VEGF, EGF and semaphorins all of which are often produced by malignant…
2015 American Transplant Congress
Alloimmune Regulation and Long-Term Allograft Survival Induced by Short-Term Administration of Chinese Medicine Cornus Officinalis and Cuscuta Sinensis Lam
Z. Dai, Y. Zeng, X. Liu, Z. Chuan.
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, China.
Achieving long-term allograft survival or tolerance without continuously global immunosuppression is a highly desirable goal. This study is to induce long-term allograft survival without long-term…
2015 American Transplant Congress
Fracture Incidence in Adult Kidney Transplant Recipients
K. Naylor,^1,2 S. Jamal,³ G. Zou,¹ E. McArthur,⁴ N. Lam,^1,2 W. Leslie,⁵ A. Hodsman,² J. Kim,^4,6 G. Knoll,⁷ L.-A. Fraser,¹ J. Adachi,⁸ A. Garg.^1,2,4
¹Western University, London, ON, Canada; ²London Health Sciences Centre, London, ON, Canada; ³Women's College Research Institute, Toronto, Canada; ⁴Institute for Clinical Evaluative Sciences, Toronto, Canada; ⁵University of Manitoba, Winnipeg, Canada; ⁶University Health Network, Toronto, Canada; ⁷Ottawa Hospital Research Institute, Ottawa, Canada; ⁸McMaster University, Hamilton, Canada.
Background: It remains uncertain whether kidney transplant recipients are a high risk group for fracture. We conducted this study to provide a precise estimate of…
2015 American Transplant Congress
Renal Transplantation in Aged Over 60 Years Demonstrates Compatible Clinical Outcomes to Younger Recipients
H. Cho,¹ H. Kim,¹ C. Baeck,¹ H. Yu,¹ D.-J. Han,² M. Jo,³ S.-K. Park.¹
¹Division of Nephrology, Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; ²Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; ³Department of Preventive Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Introduction: The aim of this study was comparing clinical outcomes of kidney transplantation between aged over 60 years and younger recipientsMethods: From 1993 to 2013,…
2015 American Transplant Congress
Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia
D. Aufhauser, Jr.,¹ Z. Wang,¹ S. Cheraghlou,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…