Am J Transplant, Volume 5, Suppl 3 Archives - Page 131 of 170 - ATC Abstracts

2015 American Transplant Congress
Constitutively Upregulated Expression of Complement and Matrix Transcripts in Kidney Transplant Recipients Who Develop Acute Rejection
K. Keslar,¹ J. Reid-Adam,⁴ E. Kwon,⁴ D. Hricik,⁵ E. Poggio,^2,3 P. Heeger,⁴ R. Fairchild.^1,3
¹Immunology, Cleveland Clinic; ²Nephrology, Cleveland Clinic; ³Glickman Urological Institute and Transplant Center, Cleveland Clinic, Cleveland, OH; ⁴Icahn School of Medicine, Mount Sinai, New York, NY; ⁵Nephrology, UH Case Medical Center, Cleveland, OH.
Identification of kidney transplants at elevated risk of acute rejection (AR) and/or chronic injury prior to loss of kidney function (GFR) could guide therapies to…
2015 American Transplant Congress
Gender Differences in Kidney Transplant Delayed Graft Function Are Independent of Donor-Recpient Size Mismatch
M. Levine,¹ A. Thomasson,¹ D. Aufhauser,¹ R. Redfield,² P. Abt,¹ P. Reese.³
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, University of Wisconsin, Madison, WI; ³Medicine, University of Pennsylvania, Philadelphia, PA.
Introduction: Superior female tolerance of ischemia reperfusion injury (IRI) relative to males has been described in animal models, but little human data are available to…
2015 American Transplant Congress
Selective Blockade of the CD28/B7/CTLA4 Pathway With Monovalent Anti-CD28 Antibodies Versus Targeting of B7 With CTLA4-Ig, in Non-Human Primate Kidney Allograft
S. Ville,¹ N. Poirier,^1,2 B. Vanhove,^1,2 G. Blancho.¹
¹INSERM, UMR1064, ITUN, Nantes, France; ²Efﬁmune SAS, Nantes, France.
B7 molecules on antigen-presenting cells interact with CD28 and CTLA4 on T lymphocytes to control TCR-mediated signals. Whereas it is highly efficient to block T…
2015 American Transplant Congress
Targeting Leukocyte Integrin CD11b/CD18 With a Novel mAb Salvages Renal Function Following an Otherwise Irreversible Ischemic Insult in Cynomolgus Monkeys
A. Cosimi,¹ A. Dehnadi,¹ R. Smith,² D. Ko,¹ X. Li,³ M. Arnaout.³
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA; ²Pathology, MGH, Boston, MA; ³Nephrology, MGH, Boston, MA.
Allograft dysfunction resulting from ischemic reperfusion injury (IRI) leads to increased peri-transplant costs, morbidity, and inferior long-term survival. Leukocyte/endothelial adhesion is an important pathway contributing…
2015 American Transplant Congress
Eculizumab in Prevention of Acute Antibody-Mediated Rejection in Sensitized Deceased-Donor Kidney Transplant Recipients: 1-Year Outcomes
D. Glotz,¹ G. Russ,² L. Rostaing,³ C. Legendre,⁴ S. Chadban,⁵ J. Grinyo,⁶ N. Mamode,⁷ E. Cozzi,¹¹ Y. Lebranchu,⁸ S. Sandrini,⁹ L. Couzi,¹² W. Marks.¹⁰
¹H St-Louis, Paris, France; ²Ryl Adelaide H, Adelaide, Australia; ³CHU Rangueil, Toulouse, France; ⁴H Necker, Paris, France; ⁵Ryl Pr Alfred H, Camperdown, Australia; ⁶H U deBellvitge, Barcelona, Spain; ⁷Guy's H, London, United Kingdom; ⁸H Bretonneau CHU, Tours, France; ⁹Spedali Cvl di Brescia, Brescia, Italy; ¹⁰Alexion, Cheshire; ¹¹Via Giustiniani, Padua, Italy; ¹²Hopital Pellegrin, CHU Bordeaux, Bordeaux, France.
Complement activation by preformed DSA is a major mechanism of acute antibody-mediated rejection (aAMR) in sensitized kidney transplant recipients (KTR). We previously reported interim study…
2015 American Transplant Congress
Pertubations in the Urinary Exosome in Transplant Rejection
T. Sigdel,¹ Y. Ng,¹ S. Lee,² C. Nicora,³ W.-J. Qian,³ D. Camp II,³ M. Sarwal.¹
¹Surgery, UC San Francisco, San Francisco, CA; ²Nephrology, Kyung Hee University, Seoul, Korea; ³Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA.
Urine exosomes are small vesicles shed into the urine by exocytosis from all renal epithelial cell types under normal physiologic states and disease states, and…
2015 American Transplant Congress
Switching from Tacrolimus to Low-Dose Cyclosporine A Preserves Allograft Function in Presumptive and Definitive Polyomavirus-Associated Nephropathy
G. Huang, C.-X. Wang, J.-G. Fei, J. Qiu, S.-X. Deng, J. Li, G.-D. Chen, Q. Fu, R.-H. Deng, L.-Z. Chen.
Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Switching from tacrolimus(Tac) to low-dose cyclosporine A(CsA) is recommended for preventing BK virus-associated nephropathy(BKVAN) and preserving allograft function in BKVAN patients, but systematic evaluations were…
2015 American Transplant Congress
Maintaining Immunosuppressive Treatment After Early Allograft Nephrectomy Does Not Reduce the Risk of Anti-HLA Allo-Sensitization
A. Del Bello,^1,2 N. Congy-Jolivet,^2,3,4 I. Cardeau-Desangles,¹ C. Guilbeau-Frugier,^2,5 E. Pambrun,¹ G. Dörr,¹ O. Milioto,⁶ L. Esposito,¹ L. Rostaing,^1,2,7 N. Kamar.^1,2,7
¹Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France; ²Université Paul Sabatier, Faculté de Médecine, Toulouse, France; ³Molecular Immunogenetics Laboratory, EA 3034, Faculté de Médecine Purpan, IFR150, Toulouse, France; ⁴Department of Immunology, CHU Rangueil, Toulouse, France; ⁵Department of Pathology, CHU Rangueil, Toulouse, France; ⁶Nephrology, Clinique Saint-Exupery, Toulouse, France; ⁷INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France.
BackgroundAnti-HLA immunization is greatly increased after early kidney-allograft failure, even if the graft is removed within a few hours post-transplantation. The aim of our study…
2015 American Transplant Congress
Assessing Transplant Attitudes: Understanding Minority Men's Perspectives on the Multifarious Barriers to Organ Donation
B. Hinck, B. Naelitz, B. Jackson, M. Howard, A. Nowacki, C. Modlin.
Glickman Urologic and Kidney Institute - Minority Men's Health Center, Cleveland Clinic, Cleveland, OH.
African-Americans comprise 13% of the US population; yet compose 34% of the kidney transplant waiting list and only 14% of cadaveric donors and 11% of…
2015 American Transplant Congress
Viral Prophylaxis Is Unnecessary in CMV Low Risk Kidney Transplant Recipients Who Receive Lymphocyte Depleting Induction
M. Gillespie,¹ B. Sirandas,² A. Carlson,² S. Lee,³ L. Smith.²
¹Pharmacy, University of Maryland, Baltimore; ²Transplant, University of Utah, Salt Lake City; ³Transplant, University of Southern California, Los Angeles.
Background: Both the international CMV consensus and AST guidelines recommend against the routine use of CMV prophylaxis in CMV D-/R- kidney transplant recipients (KTR), but…