Am J Transplant, Volume 5, Suppl 3 Archives - Page 128 of 170 - ATC Abstracts

2015 American Transplant Congress
Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection
S. Iida,¹ T. Suzuki,² K. Tanabe,¹ A. Valujskikh,³ R. Fairchild,³ R. Abe.²
¹Urology, Tokyo Women's Medical Univ, Tokyo, Japan; ²Immunology, Science University of Tokyo, Chiba, Japan; ³Immunology, Cleveland Clinic, Cleveland, OH.
【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…
2015 American Transplant Congress
Aldosterone Acts Directly On T Cells, and Promotes Production of Inflammatory Cytokines
J. Bagley, S. Begum, J. Iacomini.
Department of Developmental, Molecular and Chemical Biolgy, Tufts University Medical School, Boston.
Aldosterone is a mineralocorticoid hormone involved in the regulation of blood electrolyte concentration, blood pressure and blood volume. The primary receptor for aldosterone is the…
2015 American Transplant Congress
Serum Osteoprotegerin Levels Positively Correlate With Peripheral Arterial Stiffness in Kidney Transplantation Patients
M.-C. Lee,^1,2 G.-J. Ho,¹ Y.-C. Chen,¹ B.-G. Hsu.²
¹Department of Surgery, Tzu Chi General Hospital, Hualien, Taiwan; ²Department of Medicine, School of Medicine Tzu Chi University, Hualien, Taiwan; ³Department of Medicine, Tzu Chi General Hospital, Hualien, Taiwan.
Objective: Recent studies found osteoprotegerin (OPG) is associated with increased pulse wave velocity and may reflect endothelial dysfunction. The aim of this study was to…
2015 American Transplant Congress
Cultural Domains Affecting Organ Donation in Indian Country
T. Bongiovanni,^1,3,4 J. Rawlings,² J. Trompeta,³ M. Nunez-Smith.¹
¹Dept of Surgery, UCSF, San Francisco; ²Tribal Council, New Haven, CT; ³Robert Wood Johnson Foundation, Yale School of Medicine, New Haven, CT; ⁴Department of Veterans Affairs, West Haven.
Background: The prevalence of end-stage renal disease is 3.5 times greater among the >2.5 million Native Americans or Alaskan Natives (NAs) in the US than…
2015 American Transplant Congress
Correlation Between Level of Biomarkers Measured in Perfusate of Machine-Preserved ECD/DCD Kidneys and Post-Transplant Graft Function
E. Ablorsu,¹ S. Zouwail,² P. Laftsidis,¹ B. Cook,¹ L. Szabo.¹
¹Cardiff Transplant Unit, University Hospital for Wales, Cardiff, United Kingdom; ²The Medical Biochemistry and Immunology Department, University Hospital for Wales, Cardiff, United Kingdom.
Background:DCD and ECD kidneys are associated with higher risk of failure compare to SCD kidneys. Therefore we see increasing need to identify sensitive tool to…
2015 American Transplant Congress
The Impact of FcγRIIA, FcγRIIIA and C1QA Genes Polymorphism On Infectious Complications Following Renal Transplantation
L. Das, Y. Tanaka, S. Verma, S. Shimizu, K. Ide, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
AIM- Infectious complication is the leading cause of graft and patient loss after renal transplantation (RT). Under immunosuppressive condition when acquired immunity is suppressed, components…
2015 American Transplant Congress
CHBP in Preservation Solution and Autologous Blood Perfusate Ameliorates Ischemia Reperfusion Injury in Isolated Porcine Kidneys
C. Yang,¹ S. Hosgood,² H. Carly,² P. Meeta,² Y. Long,³ T. Zhu,¹ M. Nicholson,² B. Yang.²
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Transplant Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Leicester, China; ³Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Background. There is an imperative need to better preserve isolated organs before transplantation. A non-erythropoiesis cyclic helix B peptide (CHBP) derived from erythropoietin was newly…
2015 American Transplant Congress
Pharmacokinetics of Tacrolimus (TAC) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
E. David-Neto,¹ P. Romano,² A. Triboni,¹ F. Agena,¹ P. Ebner,² F. Ramos,¹ N. Galante,¹ F. Lemos.¹
¹Renal Transplantation Service, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Division of Central Laboratory, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…
2015 American Transplant Congress
2-Year Results on Renal Function and Safety for Everolimus plus Reduced-Exposure Calcineurin Inhibitor in Living Donor Kidney Transplant Recipients
T. Yagisawa,¹ N. Ishikawa,¹ N. Goto,² I. Nakajima,³ O. Kamisawa,⁴ S. Fuchinoue.³
¹Division of Renal and Transplantation, Jichi Medical University, Shimotsuke, Japan; ²Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ³Surgery, Kidney Center, Tokyo Women's University, Tokyo, Japan; ⁴Medical Division, Novartis Pharma K.K., Tokyo, Japan.
Purpose: The long-term effects of everolimus (EVR) with reduced cyclosporine (rCsA) exposure over 24 months on renal function and safety (viral infection) were assessed in…
2015 American Transplant Congress
Intra-Lymphocyte Concentrations of Mycophenolic Acid Correlate With the Incidence of Early Graft Rejection in Renal Transplant Recipients
Z. Md Dom,² J. Coller,² R. Carroll,³ A. Somogyi,² B. Sallustio.¹
¹Clinical Pharmacology, The Queen Elizabeth Hospital, Adelaide, Australia; ²Discipline of Pharmacology, Univeristy of Adelaide, Adelaide, Australia; ³Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia.
Introduction: Although routine therapeutic drug monitoring of mycophenolic acid (MPA) concentrations in plasma has been recommended to individualize MPA doses in transplant recipients, little is…