ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Mitochondrial Feedback Mechanisms in Kidney Cell Senescence

    K. De Vusser,1 K. Hochstenbach,2 E. Winckelmans,2 E. Lerut,3 D. Kuypers,1 T. Nawrot,2 M. Naesens.1

    1Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; 2Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; 3Department of Pathology, University Hospitals Leuven, Leuven, Belgium.

    BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…
  • 2015 American Transplant Congress

    Long-Term Outcomes and Recurrence Risk of Four Common Primary Glomerular Diseases Following Transplantation

    L. Maursetter, S. Panzer, S. Waheed, M. Mohamed, S. Parajuli, G. Leverson, B. Astor, D. Mandelbrot, A. Djamali.

    Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.

    In the largest single center study of its kind, we assessed patient and allograft outcomes in 598 patients with the four most common causes of…
  • 2015 American Transplant Congress

    Molecular Classifiers Accurately Measure the Degree of Fibrosis in Human Kidney Transplant Biopsies

    J. Venner, J. Reeve, P. Halloran.

    University of Alberta, Edmonton, Canada.

    Irreversible injury in organ transplants is an important clinical parameter, and is estimated by histology as the observed “ci” lesion, but with considerable inter-observer variability…
  • 2015 American Transplant Congress

    Comparison of Renal Outcomes for Liver Transplant Recipients With Pretransplant Renal Dysfunction Receiving Sirolimus Or Tacrolimus With Rabbit Antithymocyte Globulin Induction

    B. Duhart,1 W. Ally,2 V. Rao,3 A. Krauss,4 J. Eason,3 J. Vanatta.3

    1University of Tennessee College of Pharmacy, Memphis, TN; 2Pharmacy, University of Virginia Medical Center, Charlottesville, VA; 3Surgery, Methodist University Hospital Transplant Institute/University of Tennessee Health Science Center, Memphis, TN; 4Pharmacy, Methodist University Hospital, Memphis, TN.

    Published data are limited describing renal outcomes in orthotopic liver transplant (OLT) recipients prescribed de novo sirolimus (SRL) maintenance immunosuppression and rabbit antithymocyte globulin (rATG).…
  • 2015 American Transplant Congress

    Fast Track of Adult-to-Adult Live Donor Liver Transplant Recipients: Avoiding ICU Admission Reduces Complications and Post Transplant Hospital Stay

    J. Echeverri, N. Goldaracena, A. Singh, G. Sapisochin, N. Selzner, M. Cattral, P. Greig, L. Lilly, I. McGilvray, G. Levy, A. Ghanekar, E. Renner, D. Grant, S. McCluskey, M. Selzner.

    Toronto General Hospital, Toronto, ON, Canada.

    Objective: We investigated if fast track of adult-to-adult live donor liver transplant (LDLT) recipients is safe and provides benefits for the post transplant hospital stay.Methods:…
  • 2015 American Transplant Congress

    Outcomes After Right Kidney Living Donor Transplant Are Associated With Center Volume

    R. Reed, P. MacLennan, B. Shelton, D. Sonnier, M. Hanaway, J. Goodman, C. Young, M. Deierhoi, J. Locke.

    Surgery/Transplantation, University of Alabama at Birmingham, Birmingham, AL.

    Background: Right kidney living donor transplant (RKLDT) is a high-risk, low-volume procedure that is associated with increased risk for early graft failure. It is unclear…
  • 2015 American Transplant Congress

    Laparoscopic Donor Nephrectomy of Multiple Renal Artery Kidneys: Single Center Experience

    A. AlShahrani, M. AlBuagmi, I. AlOraifi, M. Tawfeeq.

    Multi-Organ Transplant Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

    Introduction:Laparoscopic donor nephrectomy (LDN) is the preferred procedure to procure kidneys from most living donors (LDs). However, transplant surgeons might shy away from LDN when…
  • 2015 American Transplant Congress

    Lung Biopsy Findings in Pediatric Lung Transplant Patients With Restrictive Physiology

    J. Blatter,1 F. White,2 A. Faro,1 P. Michelson,1 U. Boston,3 P. Eghtesady,3 S. Sweet.1

    1Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO; 2Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO; 3Department of Cardiothoracic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO.

    Background: Long-term survival in pediatric lung transplantation is limited by bronchiolitis obliterans (BO), but varieties of chronic lung allograft dysfunction (CLAD) are poorly understood. Restrictive…
  • 2015 American Transplant Congress

    Kidney Transplant Outcomes in Recipients Older Than 70: A Single Center Experience

    M. Yaqub, A. Sharfuddin, M. Mujtaba, D. Mishler, T. Taber, W. Goggins, N. Kassis Akl.

    Indiana University Health, Indianapolis, IN.

    Age is no longer considered a contraindication to renal transplantation. To date, little is known in regards to the grafts and patients outcomes in elderly…
  • 2015 American Transplant Congress

    Measuring Affinity of Polyclonal HLA-Specific Antibodies in Highly Sensitised Cases Can Serve as an Additional Biomarker to Guide Direct Transplantation

    S. Daga,1,2 D. Lowe,6 R. Buchli,3 J. Collard,3 A. Mulder,8 C. McMurtrey,3,4 H. Moyse,7 N. Evans,7 N. Krishnan,2 W. Hildebrand,3,4 F. Claas,8 D. Briggs,5 D. Zehnder,1,2 D. Mithcell,1 R. Higgins.1,2

    1Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; 2Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; 3Pure Protein LLC, Oklahoma; 4University of Oklahoma Health Science Center, Oklahoma City; 5Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; 6Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; 7School of Engineering, University of Warwick, Coventry, United Kingdom; 8Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.

    Significant numbers of patients on transplant waiting lists in the UK are sensitised (43%). Direct transplantation across these HLA-specific antibodies using risk stratification strategies are…
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