2015 American Transplant Congress
Plasma 4β-Hydroxycholesterol Measurement as a Potential Biomarker for CYP3A5 Activity in Informing Tacrolimus Dosing
Background—Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al, 2011). 4β-OHC concentration increases…2015 American Transplant Congress
"What's the Mileage?" Determining the Length of Time in Which Renal Function Returns to Pre-Calcineurin Discontinuation Levels in Patients With Interstitial Fibrosis
The Ohio State University, Columbus.
Calcineurin Inhibitors (CNI) use may be associated with progressive renal dysfunction. Clinical trials have shown that CNI minimization or discontinuation may aid in improvement in…2015 American Transplant Congress
Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts
Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…2015 American Transplant Congress
Vitamin D Supplementation and Acute Rejection Following Kidney Transplantation
1Barnes-Jewish Hospital, St. Louis, MO; 2Washington University in St. Louis, St. Louis, MO.
Purpose: Low serum levels of vitamin D have been associated with deleterious effects post-transplantation, including increased risk of rejection. Low serum vitamin D levels are…2015 American Transplant Congress
Characteristics and Outcomes of Patients With Incidental Hepatocellular Carcinoma Detected in the Explanted Liver Following Transplant
Introduction: Despite pre-operative cross-sectional imaging, incidental hepatocellular carcinoma (iHCC) is sometimes diagnosed upon histological examination of the liver explant following transplantation for another indication. Whilst…2015 American Transplant Congress
Health Utilities in Pediatric Liver Transplant Recipients
Pediatrics, Northwestern U, Chicago.
Health Utilities (HU) are preference based measures of health states required for cost effectiveness studies. We measured HU and health related quality of life (HRQOL)…2015 American Transplant Congress
Home Dried Blood Spot Monitoring; a New Tool for Measuring Variability in Tacrolimus Blood Levels Over Time
Oregon Health & Science University, Portland, OR.
PURPOSE: The measurement of variability in Tacrolimus (TAC) blood trough levels has been proposed to reflect the consistency with medication intake and adherence. A standard…2015 American Transplant Congress
Identification of CXCR5+EBV-Specific CD8+ T Cells in Peripheral Blood of Pediatric Heart Transplant Recipients Correlates With IL-21 Production and EBV Reactivation
Approximately 70% of EBV asymptomatic pediatric heart transplant (HTx) recipients carry chronic EBV loads in peripheral blood. These EBV loads may occur due to impaired…2015 American Transplant Congress
Program-Effect Attenuation With Time Posttransplant
The program-specific reports produced by SRTR include 1-month, 1-year, and 3-year posttransplant graft and patient survival measures. The 1-month and 1-year measures use the same…2015 American Transplant Congress
CMV IgG Provides Similar Anti-CMV Efficacy as Valganciclovir in High-Risk Organ Transplant Recipients, With Reduced Costs
Abdominal organ transplants at high risk for CMV infection (D+/R-) remain a difficult cohort to prevent late CMV infection despite prolonged valganciclovir (VGC) administration. Administration…
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