ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Adherence Time-Profiles of Renal Transplant Patients During the Three First Years Post-Transplantation

    C. Villeneuve,1,2,3 C. Monchaud,1,2,3 M. Essig,2,4 M.-L. Laroche,1,3 A. Coubret,1 I. Lacroix,5 S. Bouchet,6,7,8 D. Fruit,1,2,3 P. Merville,9 N. Kamar,10,11,12 P. Marquet,1,2,3 A. Rousseau.2,13

    1Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France; 2UMR-850, INSERM, Limoges, France; 3Laboratory of Pharmacology, Univ Limoges, Limoges, France; 4Nephrology, Dialysis and Transplantation, CHU Limoges, Limoges, France; 5Laboratory of Clinical Pharmacology, CHU Toulouse, Toulouse, France; 6UMR-876, INSERM, Bordeaux, France; 7Clinical Pharmacology, Toxicology, CHU Bordeaux, CHU Bordeaux, France; 8University Victor Ségalen Bordeaux 2, Bordeaux, France; 9Department of Nephrology, CHU Bordeaux, CHU Bordeaux, France; 10Department of Nephrology and Organ Transplantation, CHU Toulouse, Toulouse, France; 11Univ Toulouse, Toulouse, France; 12UMR-1043, IFR-BMT, INSERM, Toulouse, France; 13Biophysics, Faculty of Pharmacy, Limoges, France.

    Non-adherence to immunosuppressants (IS) has been reported to increase morbidity and mortality of transplant patients.Our objective was to investigate adherence to IS in renal transplant…
  • 2015 American Transplant Congress

    ASKP1240 in De Novo Kidney Transplant Recipients

    R. Harland,1 G. Klintmalm,2 H. Yang,3 S. Jensik,4 T. Shah,5 P. West-Thielke,6 F. Shihab,7 W. Zhang,8 V. Santos,8 R. Tainaka,8 X. Wang,8 R. First,8 J. Holman.8

    1East Carolina University, Greenville, NC; 2Baylor University Medical Center, Dallas, TX; 3Pinnacle Health System, Harrisburg, PA; 4Rush University, Chicago, IL; 5Transplant Research Institute, Los Angeles, CA; 6University of Illinois Chicago, Chicago, IL; 7University of Utah Health Science Center, Salt Lake City, UT; 8Astellas Pharma Global Development, Northbrook, IL.

    Primary objective was to evaluate the efficacy and safety of ASKP1240, antagonistic anti-CD40 antibody, in either a CNI free regimen or a CNI minimization regimen…
  • 2015 American Transplant Congress

    Depression of Complement Regulatory Factors in Human and Rat Renal Grafts in Association With Progress of Acute Cellular Rejection

    K. Yamanaka,1 T. Kato,1 Y. Kakuta,1 T. Abe,1 R. Imamura,1 A. Maeda,2 S. Miyagawa,2 N. Nonomura.1

    1Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Organ Transplantation, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

    Introduction and ObjectiveIt is commonly known that complements play important roles in antibody mediated rejection in renal transplantation. However, the association of complements with progression…
  • 2015 American Transplant Congress

    Plasmapheresis – A Previously Unrecognised Risk Factor for BK Viraemia

    E. Olayos,1 K. Barraclough,2 R. Walker,3 R. Masterson,2 H. Peter,2 C. Solomon.4

    1St Vincents Hospital, Fitroy, Victoria, Australia; 2Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia; 3Nephrology, The Alfred Hospital, Prahran, Victoria, Australia; 4Nephrology, Western Hospital, Footscray, Victoria, Australia.

    BK nephropathy is an important preventable cause of graft loss, with the only universally accepted risk factor being overall burden of immunosuppression. In the absence…
  • 2015 American Transplant Congress

    Differential Intragraft Gene Expression Profiles in Patients With Sterile Leukocyturia

    M. Ajaimy,1 P. O Broin,2 Y. Bao,1 J. Lindower,1 A. Golden,2 E. Akalin.1

    1Transplantation, Einstein/Montefiore Transplant Center, Bronx; 2Computational Genomics Facility, Albert/Einstein College of Medicine, Bronx.

    Objective: We aimed to investigate if sterile leukocyturia reflects increased intragraft immune activity and gene expression profiles of transplant kidney biopsies differ from patients without…
  • 2015 American Transplant Congress

    Speed of Onset of Donor Brain Death Leads to Differences in Renal Function and Expression of Inflammatory and Oxidative Stress Markers in Rat Kidneys

    D. Hoeksma,1 R. Rebolledo,2 M. Hottenrott,3 Y. Bodar,1 H. Leuvenink.1

    1Abdominal Surgery, University Medical Center Groningen, Groningen, Netherlands; 2Faculty of Medicine, University of Chile, Santiago, Chile; 3Cardiothoracic Surgery, University Medical Center Groningen, Groningen, Netherlands.

    IntroductionDonor brain death (BD) is an independent risk factor for primary and delayed renal graft function. Furthermore, the speed of onset of brain death, traumatic…
  • 2015 American Transplant Congress

    Incidence, Risk Factors, and Outcomes of Hospitalized Urinary Tract Infections in Kidney Transplant Recipients

    H. Pang, C. Liang, O. Famure, Y. Li, J. Kim.

    Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.

    Background: Urinary tract infections (UTIs) are common complications in kidney transplant recipients (KTRs) due to their immunocompromised state. Severe infections often lead to hospitalizations and…
  • 2015 American Transplant Congress

    Immune Response to Kidney and Pancreas Self-Antigens Are Associated With Antibody Mediated Rejection in Simultaneous Kidney Pancreas Transplants

    M. Gunasekaran,1 A. Siddiq,2 S. Shenoy,1 J. Wellen,1 T. Mohanakumar.1

    1Surgery, Washington Univ Sch of Med, St. Louis, MO; 2Medicine, Washington Univ Sch of Med, St. Louis, MO.

    Background: Simultaneous kidney-pancreas transplantation (SKP Tx) is performed as treatment option for type-1 diabetes with end stage kidney diseases. Though allograft survival was improved with…
  • 2015 American Transplant Congress

    Isotype Switching of Antibodies to Vimentin Following Transplantation Is Associated With Development of Transplant Glomerulopathy Following Renal Transplantation

    M. Gunasekaran,1 T. Maw,3 R. Santos,3 J. Wellen,1 S. Shenoy,1 T. Mohanakumar.1,2

    1Surgery, Washington Univ Sch of Med, St. Louis, MO; 2Pathology & Immunology, Washington Univ Sch of Med, St. Louis, MO; 3Medicine, Washington Univ Sch of Med, St. Louis, MO.

    Background: Immune responses to tissue restricted self antigens have been proposed to play a role in transplant glomerulopathy (TG). The goal of this study is…
  • 2015 American Transplant Congress

    Bortezomib Treatment in Antibody Mediated Rejection After Kidney Transplantation

    J. Lee,1 J. Lee,1 B. Kim,2 Y. Park,3 M. Ju,1 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Internal Medicine, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea.

    BackgroundSeveral studies demonstrated bortezomib therapy for antibody-mediated rejection (AMR) in renal transplants. However, the treatment efficacy according to target antigen or occurrence time of AMR…
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