Am J Transplant, Volume 5, Suppl 3 Archives - Page 120 of 170 - ATC Abstracts

2015 American Transplant Congress
Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells
M. Uchiyama,^1,2,3 E. Yin,^3,4 X. Jin,^3,5 T. Shimokawa,¹ H. Yagita,² M. Niimi.³
¹Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ²Immunology, Juntendo University Hospital, Tokyo, Japan; ³Surgery, Teikyo University, Tokyo, Japan; ⁴Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
2015 American Transplant Congress
Identification of Mouse Tolerogenic B Cells Expressing PD-L1/PD-L2 in B-1a Subset
T. Hirose,^1,2 Y. Tanaka,¹ H. Sakai,¹ Y. Sasaki,¹ H. Ohdan.¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan; ²Renal and Genitourinary Surgery, Hokkaido University, Sapporo, Hokkaido, Japan.
Donor lymphocyte infusion (DLI) has been shown to induce donor-specific hyporesponsiveness or even immune-tolerance among alloreactive T cells in different organ transplantation models. However, the…
2015 American Transplant Congress
South Asians Have a Higher Risk of PTDM and Death After Renal Transplantation
D.-A. Moutzouris, L. Kozia, M. Willicombe, R. Corbett, N. Duncan, J. Galliford, A. McLean, D. Taube.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
South Asians (SA) have a higher risk for cardiovascular disease and diabetes than the general population, but in renal transplant recipients, data are limited and…
2015 American Transplant Congress
Kidney Transplant Telehealh Clinic Improves Access to Long-Term Follow-Up and Decreases Costs: The Experience of the Iowa City VA Transplant Program
R. Kalil,^1,2 C. Thomas,^1,2 D. Katz.^1,2
¹Univesity of Iowa, Iowa City; ²Iowa City VAMC, Iowa City.
Kidney transplant (KT) recipients living in areas distant from transplant centers face more challenges in maintaining adequate follow-up due to long travel distances, greater costs,…
2015 American Transplant Congress
Gene Expression Profiles Indicate That Many Discarded Kidneys Are Potentially Transplantable
K. Famulski,¹ S. Niederhaus,² J. Reeve,¹ J. Bromberg,² P. Halloran.
¹University of Alberta, Edmonton, Canada; ²University of Marlyland, Baltimore.
We previously showed that the molecular kidney injury-repair response (AKI score) in implantation core biopsies (Bx) predict future graft function better than histology. This could…
2015 American Transplant Congress
Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway
J. Zhang,¹ X. Liu,² D. Li,¹ H. Dai,¹ J. Zhang,¹ T. Lu,¹ Q. Xia.¹
¹Liver Transplantation Center, Renji Hospital, Shanghai, China; ²Cardiovascular, Shanghai First People/s Hospital, Shanghai, China.
Background: FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily, which plays important roles in lipid metabolism, glucose homeostasis, inflammatory responses…
2015 American Transplant Congress
CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment
R. Hotta,¹ M. Ohira,² T. Matsuura,¹ I. Muraoka,¹ P. Tryphonopoulos,¹ J. Fan,¹ A. Tekin,¹ H. Ohdan,² A. Tzakis,³ R. Vianna,¹ S. Nishida.¹
¹University of Miami, Miami, FL; ²Hiroshima University, Hiroshima, Japan; ³Cleveland Clinic Florida, Weston, FL.
Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface…
2015 American Transplant Congress
Plasma 4β-Hydroxycholesterol Measurement as a Potential Biomarker for CYP3A5 Activity in Informing Tacrolimus Dosing
T. Elnahhas,^1,2 E. de Jonge,⁴ T. Lee,² B. van Zelst,⁴ J. Popoola,³ R. Ramkhelawon,³ R. van Schaik,⁴ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St.George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom; ⁴Clinical Chemistry, Erasmus MC Rotterdam, Rotterdam, Netherlands.
Background—Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al, 2011). 4β-OHC concentration increases…
2015 American Transplant Congress
"What's the Mileage?" Determining the Length of Time in Which Renal Function Returns to Pre-Calcineurin Discontinuation Levels in Patients With Interstitial Fibrosis
A. Diez, J. Von Visger, U. Nori, T. Pesavento, M. Henry, E. Davies, R. Pelletier.
The Ohio State University, Columbus.
Calcineurin Inhibitors (CNI) use may be associated with progressive renal dysfunction. Clinical trials have shown that CNI minimization or discontinuation may aid in improvement in…
2015 American Transplant Congress
Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts
M. Miura,¹ H. Higashiyama,¹ Y. Fukasawa.²
¹Department of Renal Transplant Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; ²Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.
Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…