2015 American Transplant Congress
South Asians Have a Higher Risk of PTDM and Death After Renal Transplantation
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
South Asians (SA) have a higher risk for cardiovascular disease and diabetes than the general population, but in renal transplant recipients, data are limited and…2015 American Transplant Congress
Kidney Transplant Telehealh Clinic Improves Access to Long-Term Follow-Up and Decreases Costs: The Experience of the Iowa City VA Transplant Program
1Univesity of Iowa, Iowa City; 2Iowa City VAMC, Iowa City.
Kidney transplant (KT) recipients living in areas distant from transplant centers face more challenges in maintaining adequate follow-up due to long travel distances, greater costs,…2015 American Transplant Congress
Gene Expression Profiles Indicate That Many Discarded Kidneys Are Potentially Transplantable
1University of Alberta, Edmonton, Canada; 2University of Marlyland, Baltimore.
We previously showed that the molecular kidney injury-repair response (AKI score) in implantation core biopsies (Bx) predict future graft function better than histology. This could…2015 American Transplant Congress
Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway
Background: FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily, which plays important roles in lipid metabolism, glucose homeostasis, inflammatory responses…2015 American Transplant Congress
CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment
Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface…2015 American Transplant Congress
Plasma 4β-Hydroxycholesterol Measurement as a Potential Biomarker for CYP3A5 Activity in Informing Tacrolimus Dosing
Background—Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al, 2011). 4β-OHC concentration increases…2015 American Transplant Congress
"What's the Mileage?" Determining the Length of Time in Which Renal Function Returns to Pre-Calcineurin Discontinuation Levels in Patients With Interstitial Fibrosis
The Ohio State University, Columbus.
Calcineurin Inhibitors (CNI) use may be associated with progressive renal dysfunction. Clinical trials have shown that CNI minimization or discontinuation may aid in improvement in…2015 American Transplant Congress
Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts
Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…2015 American Transplant Congress
Vitamin D Supplementation and Acute Rejection Following Kidney Transplantation
1Barnes-Jewish Hospital, St. Louis, MO; 2Washington University in St. Louis, St. Louis, MO.
Purpose: Low serum levels of vitamin D have been associated with deleterious effects post-transplantation, including increased risk of rejection. Low serum vitamin D levels are…2015 American Transplant Congress
Characteristics and Outcomes of Patients With Incidental Hepatocellular Carcinoma Detected in the Explanted Liver Following Transplant
Introduction: Despite pre-operative cross-sectional imaging, incidental hepatocellular carcinoma (iHCC) is sometimes diagnosed upon histological examination of the liver explant following transplantation for another indication. Whilst…
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